Title Mitochondria and cancer / Keshav K. Singh, Leslie C. Costello, editors

Published New York : Springer, ©2009

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Description 1 online resource (xii, 289 pages, 4 unnumbered pages of plates) : illustrations (some color), portraits Series 2009 Springer E-Books Contents Warburg and the Warburg hypothesis -- The marriage of genomics, proteomics and intermediary metabolism: exciting and dangerous -- Oxidative phosphorylation: the link between metabolism and cancer -- Control of glycosis and oxidative phosphorylation in fast growing tumor cells -- The role of citrate metabolism in prostate malignancy and other tumors -- The role of mitochondria in the lipogenic -- Mitochondrial apoptosis pathways in cancer -- Mitochondrial tumor suppressors and neoplastic transformation -- Mitochondrial DNA mutations and tumorigenesis -- SDHD in parganglioma -- Mitochondria in hematogic maliagncies -- Mitochondria and oncocytomas -- Extracellular matrix signaling by mitochondria -- Mitochondria as biomarkers of cancer -- Mitochondria as target of cancer therapy Summary Nearly a century of scientific research has revealed that mitochondrial dysfunction is one of the most common and consistent phenotypes of cancer cells. A number of notable differences in the mitochondria of normal and cancer cells have been described. These include differences in mitochondrial metabolic activity, molecular composition of mitochondria and mtDNA sequence, as well as in alteration of nuclear genes encoding mitochondrial proteins. This book, Mitochondria and Cancer, edited by Keshav K. Singh and Leslie C. Costello, presents thorough analyses of mitochondrial dysfunction as one of the hallmarks of cancer, discusses the clinical implications of mitochondrial defects in cancer, and as unique cellular targets for novel and selective anti-cancer therapy Bibliography Includes bibliographical references and index In Springer - LINK Subject Cancer -- Genetic aspects. Mitochondria. Mitochondrial pathology. Cell transformation. Mitochondria -- physiology Neoplasms -- metabolism Cell Transformation, Neoplastic Mitochondrial Diseases Neoplasms -- drug therapy Mitochondria MEDICAL -- Oncology. HEALTH & FITNESS -- Diseases -- Cancer. Cancer -- Genetic aspects. Mitochondria. Mitochondrial pathology. Cell transformation. Sciences de la vie. Biomédecine. Cancer -- Genetic aspects Cell transformation Mitochondria Mitochondrial pathology Form Electronic book Author Singh, Keshav K. Costello, Leslie. ISBN 9780387848341 0387848347 9780387848358 0387848355

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