Title Melanoma techniques and protocols : molecular diagnosis, treatment, and monitoring / edited by Brian J. Nickoloff ; foreword by Leroy Hood

Published Totowa, N.J. : Humana Press, ©2001

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Description 1 online resource (xv, 366 pages) : illustrations Series Methods in molecular medicine ; 61 Methods in molecular medicine ; 61. Contents The many molecular mysteries of melanoma / B.J. Nickoloff -- Isolation of tumor suppressor genes in melanoma by cDNA microarray / Y.A. Su and J.M. Trent -- Molecular characterization of melanoma-derived antigens / M. Visser [and others] -- Experimental induction of human atypical melanocytic lesions and melanoma in ultraviolet-irradiated human skin grafted to immunodeficient mice / C. Berking and M. Herlyn -- Dissection of immunosuppressive effects of ultraviolet radiation / S.E. Ullrich and D.A. Schmitt -- Antisense oligonucleotides as research tools / J.K. Taylor, S.R. Cooper and N.M. Dean -- Antisense oligonucleotides as research tools / J.K. Taylor, S.R. Cooper and N.M. Dean -- Genetic testing in familial melanoma / D. Hogg, L. Liu and N. Lassam -- Role of molecular biology in diagnostic pathology of melanoma / A. Slominski [and others] -- Identification of altered gene expression associated with pigmentary lesions by differential display analysis / I. Poole and T.L. Brown -- Fluorescence in situ hybridization as a tool in molecular diagnostics of melanoma / L.J. Coignet -- Antigen-pulsed dendritic cell approach to melanoma / F.O. Nestle, A. Tun-Kyi and M.F. Gilliet -- Gene therapy in melanoma / G. Parmiani [and others] -- Use of gene gun for genetic immunotherapy / A.E. Chang [and others] -- Role of cytokines in pathology of melanoma and use of biologic response modifiers in melanoma / J.I. Clark -- Surgical techniques for treatment of primary cutaneous melanoma / J.K. Robinson -- Utility of fine-needle aspiration biopsy for prospective analysis of patients undergoing therapy for metastatic melanoma / A.I. Riker -- A molecular technique useful in the detection of occult metastases in patients with melanoma / J.S. Goydos and D.S. Reintgen -- Immunoscope analysis of T-lymphocytes infiltrating melanocytic tumors / P. Musette [and others] -- T-cell receptor clonotype mapping using denaturing gradient gel electrophoresis / P.t. Straten [and others] -- Methods for use of peptide-MHCTetramers in tumor immunology / C. Yee and P.P. Lee Summary With the completion of the Human Genome Project, it is now possible to decipher the biochemical cascade of events that lead to melanoma, a virulent form of cancer that is currently at epidemic proportions worldwide. In Melanoma Techniques and Protocols: Molecular Diagnosis, Treatment, and Monitoring, a broadly diverse group of researchers and clinicians offer not only reviews of the most important recent advances in melanoma oncology, tumor immunology, and pathology, but also state-of-the-art molecular techniques for probing melanoma's basic biology. These readily reproducible methods can be used to develop diagnostic approaches, therapeutics, and status monitoring of patients suffering both early- and late-stage melanoma. With emphasis on the experimental details critical to success, each method is described in step-by-step fashion by hands-on masters, often those who have developed them in their own laboratories. Notes about potential pitfalls and troubleshooting tips on how to adapt procedures to new experimental systems are also provided. Comprehensive and highly instructive, Melanoma Techniques and Protocols: Molecular Diagnosis, Treatment, and Monitoring offers clinicians and basic scientists concerned with malignant melanoma both rich new clinical perspectives and the wide ranging experimental protocols essential for achieving more rapid breakthroughs in this near-epidemic disease Bibliography Includes bibliographical references and index Notes Master and use copy. Digital master created according to Benchmark for Faithful Digital Reproductions of Monographs and Serials, Version 1. Digital Library Federation, December 2002. http://purl.oclc.org/DLF/benchrepro0212 MiAaHDL English Print version record digitized 2010 HathiTrust Digital Library committed to preserve pda MiAaHDL In Springer Protocols Subject Melanoma -- Laboratory manuals Melanoma. Diseases. Melanoma Neuroendocrine Tumors Nevi and Melanomas Neuroectodermal Tumors Neoplasms by Histologic Type Neoplasms, Nerve Tissue Neoplasms Neoplasms, Germ Cell and Embryonal Disease MEDICAL -- Oncology. HEALTH & FITNESS -- Diseases -- Cancer. Diseases Melanoma Melanomen. Wetenschappelijke technieken. Genre/Form Laboratory manuals Laboratory manuals. Manuels de laboratoire. Form Electronic book Author Nickoloff, Brian J., 1953- ISBN 9781592591459 0896036847 9780896036840 1592591450 1280821108 9781280821103 9786610821105 6610821100

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