Review of the Hanford Thyroid Disease Study Draft Final Report -- Copyright -- ACKNOWLEDGEMENTS -- Contents -- Public Summary -- BACKGROUND -- DESIGN OF THE HTDS -- Estimated Radiation Exposures -- Analysis of HTDS Data -- Statistical Power and the HTDS Interpretation -- Communication of HTDS Results to the Public -- Concluding Remarks -- Executive Summary -- BACKGROUND -- EPIDEMIOLOGIC AND CLINICAL METHODS AND DATA COLLECTION -- Conclusions: -- Recommendations: -- DOSIMETRY -- Conclusions: -- Recommendations: -- STATISTICAL ANALYSES
Conclusions:Recommendations: -- STATISTICAL POWER AND INTERPRETATION OF THE STUDY -- Conclusions: -- Recommendations: -- COMMUNICATION OF THE STUDY RESULTS TO THE PUBLIC -- Conclusions: -- Recommendations: -- SUMMARY OF RESPONSES TO THE CDC'S QUESTIONS -- 1 Introduction -- 2 Overview of the HTDS Draft Final Report and Organization of the Committee's Report -- 3 Evaluation of Epidemiologic and Clinical Methods -- EVALUATION OF EPIDEMIOLOGIC METHODS -- MILK-CONSUMPTION ESTIMATION -- EVALUATION OF CLINICAL-DATA COLLECTION
COMPLETENESS OF ASCERTAINMENT OF THYROID DISEASESUSCEPTIBILITY FACTORS FOR THYROID DISEASE -- EVALUATION OF MORTALITY DATA -- AMERICAN INDIAN TRIBAL ISSUES -- 4 Evaluation of Dosimetric Methods and Results -- BACKGROUND -- HEDR CALCULATIONS OF ENVIRONMENTAL CONCENTRATIONS OF 131I FROM HANFORD AND RESULTING DOSES: ASSESSME ... -- Source Term: -- Concentration of131I in Pasture Grass at Time of Fallout: -- Mean Time of Residence of 131I on Pasture Grass: -- Pasture Intake by Cows: -- Transfer Coefficient of 131I from Cow's Intake to Milk
Milk-Distribution Factor:Milk-Consumption Rate: -- Thyroid Dose Coefficient: -- HEDR DOSIMETRY-MODEL VALIDATION -- Thyroid Burdens -- Milk Concentrations -- Concentrations in Vegetation -- Concentrations in Air -- Conclusions -- Possible Underestimation or Overestimation of Doses -- DOSE UNCERTAINTIES -- 131I FROM THE NEVADA TEST SITE AND GLOBAL FALLOUT -- OTHER SOURCES OF RADIATION EXPOSURE -- 5 Evaluation of Statistical Data Analysis -- MODE OF PRESENTATION OF RESULTS -- TYPES OF ANALYSES AND RELATED DOSIMETRY-ERROR ISSUES
ANALYSIS OF POTENTIAL CONFOUNDING OR EFFECT-MODIFYING VARIABLESASSUMPTION OF EQUIVALENT RADIATION EFFECT FOR MALES AND FEMALES -- ANALYSES BY AGE AT EXPOSURE -- OUT-OF-AREA ANALYSES -- GEOSTRATUM VERSUS DISEASE -- GENERAL-POPULATION COMPARISON AND SCREENING ISSUES -- ANALYSES OF SOURCE OF PERSONAL-EXPOSURE INFORMATION -- 6 Statistical Power and Interpretation of the Study -- FACTORS IN STATISTICAL POWER -- SAMPLE SIZE AND ASSUMED BACKGROUND PREVALENCE OF DISEASE -- EFFECT OF DOSIMETRY ERROR ON STATISTICAL POWER -- VIOLATION OF THE BERKSON ERROR ASSUMPTION
