Title Evaluation of a sex-specific difference in lung cancer radiation risk and approaches for improving lung cancer radiation risk projection (with a focus on application to space activities) / prepared by SC 1-27 on Evaluation of Sex-Specific Differences in Lung Cancer Radiation Risks and Recommendations for Use in Transfer and Projection Models

Published Bethesda : National Council on Radiation Protection and Measurements, December 31, 2022

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Description 1 online resource Series NCRP commentary; no. 32 NCRP commentary ; no. 32. Summary "The study of Japanese atomic-bomb survivors exposed acutely to ionizing radiation in 1945 reported the risk of radiation-related lung cancer to be nearly three times greater for females than for males on a relative scale (similar for both mortality and incidence). The operational model for risk of exposure-induced death currently in use by the National Aeronautics and Space Administration (NASA) relies on data from the Japanese atomic-bomb survivor study. According to the NASA model, radiation-related lung cancer is the largest contributor to fatal cancer risk. The sex-specific difference in lung cancer observed for Japanese atomic-bomb survivors is used in the model, resulting in a higher estimated total cancer mortality risk for female astronauts than for male astronauts for the same level of exposure. NASA requested that the National Council on Radiation Protection and Measurements (NCRP) evaluate the risk of radiation-related lung cancer in populations exposed to chronic (protracted or fractionated) radiation, in order to investigate whether a similar sex- specific difference in lung cancer risk is observed when exposure occurs gradually over years (such as experienced by astronauts during space missions) contrasted with the acute exposure received by the Japanese atomic-bomb survivors"-- Provided by publisher Bibliography Includes bibliographical references Notes Description based on print version record and CIP data provided by publisher; resource not viewed Subject Astronauts. Lungs -- radiation effects Risk assessment. Lung Neoplasms Lung -- radiation effects Lung Neoplasms -- epidemiology Neoplasms, Radiation-Induced -- prevention & control Organs at Risk -- radiation effects Risk Assessment -- methods Astronauts Risk Assessment astronauts. risk assessment. Astronauts Risk assessment Form Electronic book Author National Council on Radiation Protection and Measurements, issuing body. LC no. 2022048514 ISBN 9781944888336 1944888330 1523151285 9781523151288

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