| Description |
1 online resource (1000 pages) |
| Contents |
Title Page ; Copyright Page; Contents; List of€Contributors; Preface; Chapter 1 An Overview of€Molecular Cancer Pathogenesis, Prognosis, and Diagnosis; Fundamentals of€cancer biology; Genetic injury; Epigenetics; Tumor heterogeneity, tumor progression, and€clonal evolution; The hallmarks of€malignancy; Sustaining proliferative signaling: proto-oncogenes and oncogenes ; Evading growth suppressors; Resisting cell death; Enabling reproductive immortality; Inducing angiogenesis; Activating invasion and€metastasis; References |
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Veterinary cancer incidence and€molecular approaches to€diagnosis and€prognosisGenetics and€cancer; From concepts to€clinics: molecular genetics usher in€an€era of€opportunity; Cytogenetics in€cancer; Molecular diagnostics and€prognostics; Evolutionarily conserved genomic changes in€cancers; Molecular assays in€veterinary oncology; Conclusions; References; Chapter 2 Trimming Tumors for€Diagnosis and€Prognosis; Specimen sizing; Orientation of€trimmed specimens; Perpendicular margins; Parallel margins (en face); Margin evaluation; Skin tumors; Canine soft tissue sarcomas and€mast cell€tumors |
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Digital amputationsLimb amputations; Ears; Eyelids; Intraocular tumors; Hemimandibulectomies/maxillectomies; Gastrointestinal tumors; Tumors of€parenchymal organs; Tumors of€lobar parenchymal organs; Lymph nodes; References; Chapter 3 Immunohistochemistry: Fundamentals and€Applications in€Oncology; Introduction; References; The immunohistochemical test; Fixation and€processing; References; Antigen retrieval; Enzymatic retrieval; Heat-induced epitope retrieval (HIER) ; References; Antigens and€antibodies; Antigens; Antibodies; Affinity; Avidity; Polyclonal antibodies; Monoclonal antibodies |
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What makes an€antibody good for€immunohistochemistry?References; Detection methods; Avidin-biotin methods; Polymeric labeling two-step method ; Catalyzed signal amplification; Immunohistochemistry on€mouse tissues; References; Storage and€handling of€reagents; References; Controls in€immunohistochemistry; Positive tissue control; Negative tissue control; Reagent (antibody) controls; Methods for high-throughput evaluation of control tissues ; References; Standardization (optimization) and€validation€of€a€new IHC test; Primary antibody standardization and€validation |
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Laboratory validation of€the€IHC testClinical validation of€the€IHC test; References; Immunohistochemical report and€interpretation; Patterns of€specific labeling; Patterns of€nonspecific labeling; What constitutes a€positive/significant result?; Distinguishing true-positive from false-positive immunoreactivity ; References; Troubleshooting the€IHC test; Background staining; References; Approach to€the€immunohistochemical characterization of€tumors; Biomarkers in€diagnostic immunohistochemistry of€neoplasms; Prognostic markers and€immunohistochemistry; References |
| Notes |
Cancer of€unknown primary site |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Print version record |
| Subject |
Tumors in animals.
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Veterinary oncology.
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Domestic animals.
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Neoplasms -- veterinary
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Animals, Domestic
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Domestic animals
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Tumors in animals
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Veterinary oncology
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| Form |
Electronic book
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| ISBN |
9781119181194 |
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9781119181187 |
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1119181186 |
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1119181194 |
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