1. Historical perspective of the synapse -- 2. The role of calcium in transmitter release -- 3. How transmitter release is triggered -- 4. Ionotropic receptors mediate fast synaptic responses -- 5. Metabotropic receptors mediate slow synaptic responses -- 6. Historical perspective of neuronal plasticity -- 7. Functional plasticity at synapses -- 8. Molecular cascades in learning -- 9. Morphological plasticity at synapses -- 10. Historical perspective of neurotrophism -- 11. Neurotrophic factors responsible for neuronal survival -- 12. Neurotrophic regulation at developing synapses -- 13. Target-dependence of the neuronal state