Title Axonal branching and recovery of coordinated muscle activity after transection of the facial nerve in adult rats / D.N. Angelov [and others]

Published Berlin ; New York : Springer, 2005

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Description 1 online resource (viii, 130 pages) : illustrations Series Advances in anatomy, embryology, and cell biology, 0301-5556 ; 180 Advances in anatomy, embryology, and cell biology ; 180. 0301-5556 Contents Outline of the General Neurobiological Problem -- The Perikarya Which Support Axonal Regrowth are Hyperexcitable -- Axonal Regrowth is Compromised by Ephaptic Cross-Talk Between the Branches -- Biological Significance of Axonal Branching -- Role of Cytoskeleton Reorganization During Axonal Branching -- The Individual Guidance Cues Promoting Reinnervation of Original Targets are Still Unknown -- Conclusion -- Outline of the Clinical Problem -- Questions Still Open -- Methodological Approach -- Materials and Methods -- First Set of Experiments: Attempts to Reduce Collateral Axonal Branching by Alterations of the Trigeminal Input to the Facial Perikarya -- Second Set of Experiments: Attempts to Reduce Collateral Axonal Branching at the Lesion Site -- Results -- First Set of Experiments: Influence of the Altered Afferent Input to Axotomized Facial Perikarya on the Quality of Reinnervation -- Second set of Experiments: Attempts to Reduce Collateral Axonal Branching at the Lesion Site -- Discussion -- The Combined Approach to Evaluate the Quality of Peripheral Nerve Regeneration -- Sensory-Motor Integrity as A Factor for Motor Regeneration -- Collateral Branching Versus Terminal Sprouting of Axons -- Prospects for the Future -- References -- Subject index Summary Facial nerve surgery inevitably leads to partial pareses, abnormally associated movements and pathologically altered reflexes. The reason for this "post-paralytic syndrome" is the misdirected reinnervation of targets, which consists of two major components. First, due to malfunctioning axonal guidance, a muscle gets reinnervated by a "foreign" axon, that has been misrouted along a "wrong" fascicle. Second, the supernumerary collateral branches emerging from all transected axons simultaneously innervate antagonistic muscles and cause severe impairment of their coordinated activity. Since it is hardly possible to influence the first major component and improve the guidance of several thousands axons, the authors concentrated on the second major component and tried to reduce the collateral axonal branching Analysis biomedische wetenschappen biomedicine neurowetenschap neuroscience Medicine (General) Geneeskunde (algemeen) Bibliography Includes bibliographical references (pages 109-130) and index Notes Print version record In Springer e-books Subject Nervous system -- Regeneration. Axons -- Physiology Nerves, Peripheral -- Wounds and injuries. Facial nerve -- Wounds and injuries Muscles -- Innervation Axons -- physiology Nerve Regeneration Facial Nerve -- physiology Facial Nerve -- surgery Nerve Regeneration -- physiology Rats -- physiology Rats -- surgery SCIENCE -- Life Sciences -- Zoology -- General. Axons -- physiology. Nerves, Peripheral -- Wounds and injuries. Facial nerve -- Wounds and injuries. Muscles -- Innervation. Facial Nerve -- physiology. Facial nerve -- Surgery. Nerve Regeneration -- physiology. Rats -- Physiology. Rats -- surgery. Nervous system -- Regeneration. Biomédecine. Sciences de la vie. Muscles -- Innervation Nerves, Peripheral -- Wounds and injuries Nervous system -- Regeneration Form Electronic book Author Angelov, D. N. (Doychin N.), 1953- ISBN 9783540299318 3540299319 3540256547 9783540256540 6610337926 9786610337927

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