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Book Cover
Author Nelms, Brian L., author.

Title Transcriptional control of neural crest development / Brian L. Nelms and Patricia A. Labosky
Published San Rafael, CA : Morgan & Claypool Life Sciences, [2010]


Description 1 online resource : illustrations (chiefly color)
Series Developmental biology ; Book #1
Colloquium series on developmental biology ; #1.
Contents 880-01 AP Genes -- bHLH Proteins -- ETS Genes -- Fox Genes -- Homeobox Genes -- Hox Genes -- Lim Genes -- Pax Genes -- POU Domain Genes -- RAR/RXR Genes -- Smad Genes -- Sox Genes -- Zinc Finger Genes -- Other Miscellaneous Genes
880-01/(S 2.2.3 Zebrafish AP-2α Mutants2.2.4 Xenopus AP-2a; 2.2.5 Regulation of AP-2; 2.2.6 AP-2 Targets; 2.2.7 AP-2 Binding Sites; 2.2.8 AP-2 as an NC Marker; 2.3 AP-2b (Tcfap2b); 2.4 AP-2g (Tcfap2c); 2.5 AP-2d (Tcfap2d) AND AP-2e (Tcfap2e); chapter 3 bHLH Proteins; 3.1 Ascl1; 3.1.1 Ascl1 in the Sympathoadrenal Lineage; 3.1.2 Regulation of Ascl1 by BMP, cAMP, and Notch Signaling; 3.1.3 Ascl1 Interaction with Other Transcription Factors and Targets; 3.1.4 Ascl1 in Human Disease; 3.2 Hand1; 3.3 Hand2; 3.3.1 Hand2 in the Pharyngeal Arches and Derivatives; 3.3.2 Hand2 in the Heart
Summary "The neural crest is a remarkable embryonic population of cells found only in vertebrates and has the potential to give rise to many different cell types contributing throughout the body. These derivatives range from the mesenchymal bone and cartilage comprising the facial skeleton, to neuronal derivatives of the peripheral sensory and autonomic nervous systems, to melanocytes throughout the body, and to smooth muscle of the great arteries of the heart. For these cells to correctly progress from an unspecified, nonmigratory population to a wide array of dynamic, differentiated cell types--some of which retain stem cell characteristics presumably to replenish these derivatives--requires a complex network of molecular switches to control the gene programs giving these cells their defining structural, enzymatic, migratory, and signaling capacities. This review will bring together current knowledge of neural crest-specific transcription factors governing these progressions throughout the course of development. A more thorough understanding of the mechanisms of transcriptional control in differentiation will aid in strategies designed to push undifferentiated cells toward a particular lineage, and unraveling these processes will help toward reprogramming cells from a differentiated to a more naive state."
Analysis Neural crest
Zinc finger
Bibliography Includes bibliographical references
Notes English
Online resource; title from resource home page (NCBI Bookshelf, viewed December 27, 2013)
Subject Neural crest.
Genetic transcription.
Neural Crest -- embryology
Transcription Factors -- metabolism
Embryonic Development -- genetics
Gene Expression Regulation, Developmental
Neurulation -- genetics
Transcription, Genetic
Neural Crest
SOCIAL SCIENCE -- Anthropology -- Physical.
Genetic transcription.
Neural crest.
Form Electronic book
Author Labosky, Patricia A., author.
ISBN 9781615040490
Other Titles Colloquium digital library of life sciences: Collection 1
NCBI Bookshelf