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Title Neural crest cells : evolution, development and disease / edited by Paul A. Trainor
Published Amsterdam : Elsevier/AP, ©2014


Description 1 online resource : illustrations
Contents Front Cover; Neural Crest Cells: Evolution, Development and Disease; Copyright Page; Contents; Preface; Acknowledgment; Contributors; I: Neural Crest Cell Evolution and Development; 1 The Neural Crest, a Fourth Germ Layer of the Vertebrate Embryo: Significance in Chordate Evolution; General Characteristics of the Neural Crest; Transition from Invertebrates Chordates to Vertebrates; The Molecular Control of EMT Studied in NCC Development; Role of the NC in the Development of the Vertebrate Head; The Evolutionary Origin of the Vertebrate Nervous System
The Genetic Identity of Vertebrate Secondary Brain Organizers as Landmarks for CNS Evolution in DeuterostomesAre Precursors of the NC Present in non-vertebrate Chordates?; The Multiple Roles of the NC in the Construction of the Vertebrate Head and Brain; Hox Gene Expression in the Cephalic NC; Malformations of the Brain Induced by FSNC Removal; Effect of Forced Expression of Hox Genes in the FSNC on Face and Brain Development; Role of the Cephalic NC in the Regulation of Fgf8 Production by the ANR and Isthmus; The Evolution of Skeletal Structures in the Vertebrate Phylum
Conclusions and PerspectivesAbbreviations; References; 2 Induction and Specification of Neural Crest Cells: Extracellular Signals and Transcriptional Switches; Introduction; NC Induction at the NPB; Timing and Tissues; Signaling Factors; Bone Morphogenetic Protein Signaling; Wnt Signaling; Fibroblast Growth Factor Signaling; Other Signaling Pathways; Gene Regulatory Network Involved in NC Specification; NPB Specifier Genes; NC Specifier Genes; Conclusions and Perspectives; References; 3 The Cell Biology of Neural Crest Cell Delamination and EMT; Introduction; Loss of Intercellular Adhesion
Adherens JunctionsCadherins; Chick; Xenopus; Zebrafish and Mouse; Catenins; Tight Junctions; Claudin-1; Cingulin; Acquisition of Migratory Capacity; Rho GTPases and the Cytoskeleton; Appropriate Substrate for Migration; Breakdown of Basal Lamina; ECM; Integrins; Conclusions and Perspectives; References; 4 Neural Crest Cell Migration: Guidance, Pathways, and Cell-Cell Interactions; Pathways of Neural Crest Cell Migration: An Overview; Cephalic Neural Crest Cell Migration; Inhibitors; Positive Regulators of Cephalic Neural Crest Cell Migration; Trunk Neural Crest Cell Migration
The Ventromedial PathwayThe Dorsolateral Pathway; Cell-Cell Interactions During Neural Crest Cell Migration; Neural Crest-Neural Crest Interactions and Cell Polarity; Neural Crest-Neural Crest Interactions Promote Collective Guidance; CIL-Based Dispersion Is Counterbalanced by Mutual Attraction to Promote Collective Cell Migration; Dialogue Between Neural Crest Cells and Their Local Environment; Conclusion and Perspectives; Acknowledgments; References; 5 Epigenetic Regulation of Neural Crest Cells; Introduction; Histone Modifications; Methylation; Acetylation; Histone Variants
Summary Neural Crest Cells: Evolution, Development and Disease summarizes discoveries of historical significance and provides in-depth, current analyses of the evolution of neural crest cells, their contribution to embryo development, and their roles in disease. In addition, prospects for tissue engineering, repair and regeneration are covered, offering a timely synthesis of the current knowledge in neural crest cell research. A comprehensive resource on neural crest cells for researchers studying cell biology, developmental biology, stem cells and neurobiology, Neural Crest Cells: Evolut
Bibliography Includes bibliographical references and index
Notes Print version record
Subject Neural crest -- Cytology
Vertebrates -- Evolution.
Vertebrates -- Development
Evolution (Biology)
Neural Crest -- cytology
Neural Crest -- embryology
Biological Evolution
Vertebrata (subphylum)
SOCIAL SCIENCE -- Anthropology -- Physical.
Evolution (Biology)
Vertebrates -- Development
Vertebrates -- Evolution
Health & Biological Sciences.
Animal Anatomy & Embryology.
Crête neurale -- Cytologie.
Crête neurale -- Embryologie.
Vertébrés -- Évolution.
Vertébrés -- Développement.
Form Electronic book
Author Trainor, Paul A.
LC no. 2014378838
ISBN 9781306167857