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Book Cover
Author Crichton, Robert R., author

Title Metal-based neurodegeneration : from molecular mechanisms to therapeutic strategies / Robert Crichton and Roberta Ward
Edition Second edition
Published Chichester, West Sussex : John Wiley & Sons, Ltd., 2014


Description 1 online resource (439 pages) : illustrations (chiefly color)
Contents Brain function, physiology, and the blood-brain barrier -- Role of metal ions in brain function, metal transport, storage, and homeostasis -- Immune system and neuroinflammation -- Oxidative stress in neurodegenerative diseases -- Aging and mild cognitive impairment, MCI -- Parkinson's disease -- Alzheimer's disease -- Huntington's disease and polyglutamine expansion neurodegenerative diseases -- Friedreich's ataxia and diseases associated with expansion of non-coding triplets -- Creutzfeldt-Jakob and other prion diseases -- Amyotropic lateral sclerosis -- Alcoholic brain damage -- Other neurological diseases -- Therapeutic strategies to combat the onset and progression of neurological diseases
Summary Neurodegenerative diseases of the human brain appear in various forms, resulting in disorders of movement and coordination, cognitive deterioration and psychiatric disturbances. Many of the key factors leading to neurodegenerative diseases are similar, including the dysfunction of metal ion homeostasis, redox-active metal ions generating oxidative stress, and intracellular inclusion bodies. Metal-based Neurodegeneration presents a detailed survey of the molecular origins of neurodegenerative diseases. Each chapter is dedicated to a specific disease, presenting the latest scient
Bibliography Includes bibliographical references and index
Notes Online resource; title from electronic title page (ebrary, viewed on March 4, 2015)
Subject Nervous system -- Degeneration -- Etiology
Brain -- Pathophysiology
Oxidative stress.
Metals -- Health aspects
Neurodegenerative Diseases -- etiology
Neurodegenerative Diseases -- metabolism
Brain -- physiology
Metals -- adverse effects
Oxidative Stress
HEALTH & FITNESS -- Diseases -- General.
MEDICAL -- Clinical Medicine.
MEDICAL -- Diseases.
MEDICAL -- Evidence-Based Medicine.
MEDICAL -- Internal Medicine.
Brain -- Pathophysiology
Metals -- Health aspects
Oxidative stress
Form Electronic book
Author Ward, Roberta J., author
ISBN 9781118553497