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Author Klimaschewski, Lars P

Title Parkinson's and Alzheimer's today : about neurodegeneration and its therapy / Lars P. Klimaschewski
Published Berlin, Germany : Springer, 2022


Description 1 online resource (xiii, 153 pages) : color illustrations
Contents Intro -- Preface -- Contents -- 1 Introduction to Brain Development: Why do We Need so Many Nerve Cells? -- 1.1 Neurons and Glia in the Central Nervous System -- 1.2 What Happens During Brain Development? -- 1.3 Evolutionarily Old Brain Parts are Simpler in Structure than the Neocortex -- 1.4 What Distinguishes the Left from the Right Brain? -- 1.5 Brain Development in Childhood and Adolescence -- 1.6 The Child's Brain is Enormously Plastic and can Still Heal -- 1.7 Is a Large Brain "Smarter" than a Small One? -- 1.8 Absolute and Relative Brain Weight
1.9 With the Second Evolutionary Leap, Our Brain Reaches its Maximum Size -- 1.10 Neural Stem Cells Remain Capable of Dividing for a Long Time -- 1.11 The Frontal Lobe is Especially Important for Higher Brain Functions -- 1.12 The Prefrontal Cortex Encodes Human Specific Properties -- 1.13 Brain Performance in Comparison -- Further Reading -- 2 Aging and Neurodegenerative Diseases: Why do Nerve Cells Die? -- 2.1 The Normal Aging Process -- 2.1.1 Mechanisms of Cellular Aging -- DNA Telomeres Determine the Number of Cell Divisions -- Aging Cells Maintain a Chronic Inflammation
The Importance of Protein Homeostasis for Cellular Aging -- Self-cleaning of Nerve Cells -- Two Sides of a Coin: Oxygen Radicals -- Endogenous Radical Scavengers Protect Our Nerve Cells -- Chronic Inflammatory Processes in the Brain -- 2.1.2 Neuronal Cell Death -- How do neurons die? -- 2.1.3 Blood Supply of the Aging Brain -- Barrier Disorders are Not Uncommon in the Elderly -- 2.2 Parkinson's Disease -- 2.2.1 General Pathomechanisms -- The Problem with Parkinson's Begins in the Lower Brainstem -- 2.2.2 Special Morphology of Affected Neurons -- Special Requirements for Highly Branched Neurons
Many Amine-releasing Neurons are Constantly Active and Therefore More Easily Stressed -- 2.2.3 Specific Causes of Parkinson's Disease -- 2.2.4 Alpha-synuclein: A Key Protein in Parkinson's Disease -- Fibrils Are More Dangerous Than Aggregates -- Aggregates Are Not Only Found in Nerve Cells -- 2.2.5 The Prion Theory of Parkinson's Disease -- Cranial Nerves Transport Pathological Proteins into the Brain -- The Difficulties of a Clear Pathogenesis of Parkinson's Disease -- 2.3 Dementia and Alzheimer's Disease -- 2.3.1 How Does Alzheimer's Disease Manifest Itself? -- 2.3.2 General Pathomechanisms
Summary What happens in the brain when we are ageing? How does neuronal cell death occur when we become forgetful? Which new therapies are available to combat the death of brain cells? This non-fiction book informs those interested in neuroscience and medicine about the latest findings on the therapy of neurodegeneration with a focus on Alzheimer's dementia and Parkinson's disease. Supported by illustrative drawings, Lars P. Klimaschewski presents the latest developments in neurobiological research on ageing in a comprehensible way and reports exciting news from the Alzheimer's and Parkinson's laboratories worldwide. From the contents Introduction to brain development: Why do we need billions of nerve cells? What distinguishes our cerebral cortex from that of other mammals? - Ageing and neurodegenerative diseases: Why are nerve cells lost? The normal ageing process; B-synuclein: A key protein in Parkinson's disease; Dementia and Alzheimer's disease: The amyloid and tau pathology; Viral infections in neurodegenerative diseases: Does Covid-19 lead to neurodegeneration? - Saving or replacing nerve cells: Stem cell, immune or antisense therapies? The author Prof. Dr. med. Lars P. Klimaschewski is a professor at the Medical University of Innsbruck, head of the Institute of Neuroanatomy there and the author of numerous papers on neuronal degeneration and regeneration
Bibliography Includes bibliographical references
Notes Online resource; title from PDF title page (SpringerLink, viewed December 19, 2022)
Subject Parkinson's disease.
Alzheimer's disease.
Alzheimer Disease
Neurodegenerative Diseases
Neurodegenerative Diseases -- epidemiology
Parkinson Disease
Alzheimer's disease
Parkinson's disease
Form Electronic book
ISBN 9783662663691