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Title Antioxidants and functional foods for neurodegenerative disorders : uses in prevention and therapy / edited by Abhai Kumar, Debasis Bagchi
Edition First edition
Published Boca Raton, FL : CRC Press, 2021


Description 1 online resource
Contents Cover -- Half Title -- Title Page -- Copyright Page -- Dedication -- Table of Contents -- Preface -- Editor -- Contributors -- Part I: Overview & Introduction -- Chapter 1 Role of Oxidative Stress in Neurodegeneration -- 1.1 Neurodegeneration -- 1.1.1 Alzheimer's Disease (AD) -- 1.1.2 Parkinson's Disease (PD) -- 1.1.3 Amyotrophic Lateral Sclerosis (ALS) -- 1.1.4 Huntington's Disease (HD) -- 1.1.5 Stroke -- 1.1.6 Multiple Sclerosis (MS) -- 1.2 Role of Oxidative Stress and Protective Effect of Free Radical Scavengers -- 1.3 Conclusion -- References
2.5.1 Mitochondria and Redox Regulation of Cell Signaling -- 2.5.2 JNK, Oxidative Stress, and Energy Production -- 2.5.3 H[sub(2)]O[sub(2)] and Insulin Signaling -- 2.6 Clinical Manifestations in Diabetic Patients -- References -- Part II: Molecular Mechanisms of Neurodegenerative Disorders, Inflammation, and Oxidative Stress -- Chapter 3 Oxidative Stress and Inflammation -- 3.1 Introduction -- 3.2 Mechanism of Generation of Oxidative Stress -- 3.2.1 Sources/Sites of ROS Generation -- 3.3 Risk Factors Associated with Oxidative Stress -- 3.4 Relationship Between Oxidative Stress and Inflammation
3.5 Oxidative Stress, Neuroinflammation, and Neurodegenerative Diseases -- 3.5.1 Alzheimer's Disease (AD) -- 3.5.2 Amyotrophic Lateral Sclerosis (ALS) -- 3.5.3 Huntington's Disease (HD) -- 3.5.4 Multiple Sclerosis (MS) -- 3.5.5 Parkinson's Disease (PD) -- 3.6 Conclusion -- Declaration of Competing Interest -- References -- Chapter 4 Role of Environmental Toxicants and Inflammation in Parkinson's Disease -- 4.1 Introduction -- 4.2 Background Details on PD -- 4.2.1 A Historical Viewpoint of PD -- 4.2.2 Clinical Manifestations of PD -- Initial Symptoms -- Primary Motor Symptoms Secondary Motor Symptoms -- Primary Nonmotor Symptoms -- Secondary Nonmotor Symptoms -- 4.2.3 Neuropathological and Neurochemical Aspects of PD -- 4.2.4 Origins of Motor Dysfunction in PD -- 4.3 Molecular Mode of Action of PD -- 4.3.1 Oxidative Stress in PD -- 4.3.2 Modified Mitochondrial Activity in PD -- 4.3.3 Modified Proteolysis in PD -- 4.3.4 Inflammatory Alteration -- 4.3.5 Excitotoxic Mechanisms -- 4.4 PD and Environmental Toxin Exposure -- 4.4.1 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine (MPTP) -- 4.4.2 Pesticides -- 4.4.3 Rotenone -- 4.4.4 Paraquat and Maneb
Summary "Neurodegenerative diseases, including Alzheimer's and Parkinson's disease, are a growing problem across the world's aging population. Oxidative stress in the brain plays a central role in a common pathophysiology of these diseases. This book presents scientific research on the potential of antioxidant therapy in the prevention and treatment of neurodegenerative disorders. This book outlines the roles of oxidative stress and diabetes mellitus in neurodegeneration, describes the molecular mechanisms of neurodegenerative disorders including the roles of environmental pollutants and inflammatory responses, and explores mitochondrial dysfunction. It then describes the protective abilities of antioxidants - including vitamin D, tocotrienol and coenzyme Q10 - against neurodegeneration. The book demonstrates the therapeutic potential of ketogenic diets, and highlights the roles of medicinal plants, phytopharmaceuticals, traditional medicines and food nutrients in neuroprotection. Key Features: Explains damage caused by numerous neurodegenerative disorders and the possible protection offered by antioxidants and functional foods. Describes molecular mechanisms of neurodegeneration by oxidative stress, advancing age, diabetes and mitochondrial dysfunctions. Demonstrates protection offered by nutraceuticals, antioxidants, botanical extracts and functional foods. The book contains twenty-three chapters divided into six sections written by leading researchers. This book is essential reading for health professionals, dietitians, food and nutrition scientists and anyone wanting to improve their knowledge of etiology of neurodegenerative diseases"-- Provided by publisher
Bibliography Includes bibliographical references and index
Notes Abhai Kumar, Ph. D., received his Ph. D. degree in Biotechnology in 2008. Dr. Abhai is currently working as Research Scientist at DBT-BHU Interdisciplinary School of Life Sciences and Consultant Research Scientist at Department of Neurology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India. Dr. Abhai served as Postdoctoral Fellow at University of Pittsburgh, Pittsburgh, USA from 2008 to 2010. Dr. Abhai identified several novel drug targets during his work at University of Pittsburgh, USA. He worked at India most prestigious institute National Institute of Immunology, New Delhi on glycoproteomics for drug targets of cancer . Dr. Abhai has published many research articles in journal of high impacts and wrote book chapter in various prestigious international books. He is reviewer of several journals and editorial board member. He is also working as ex-officio member of 'Chand Foundation' a voluntary organization dealing with mental health of elderly people in India. Dr. Abhai research interests include neurodegenerative disorders, free radicals, human diseases, anti-ageing and anti-inflammatory pathophysiology, and cognition. Debasis Bagchi, PhD, MACN, CNS, MAIChE, received his Ph. D. in Medicinal Chemistry in 1982. Dr. Bagchi is a Professor in the Department of Pharmacological and Pharmaceutical Sciences at the University of Houston, College of Pharmacy, Houston, TX, and the Chief Scientific Officer, R & D, Cepham Inc. Piscataway, NJ. He is also an Adjunct Faculty of the School of Pharmacy, Texas Southern University, Houston, TX. He served as the Senior Vice President of Research & Development of InterHealth Nutraceuticals Incorporated in Benicia, CA, from 1998 till Feb 2011. Dr. Bagchi received the Master of American College of Nutrition Award in early October 2010. He is currently the Chairman of International Society of Nutraceuticals and Functional Foods (ISNFF), Past President of American College of Nutrition, Clearwater, FL, and Past Chair of the Nutraceuticals and Functional Foods Division of Institute of Food Technologists (IFT), Chicago, IL. He is serving as a Distinguished Advisor on the Japanese Institute for Health Food Standards, Tokyo, Japan. Dr. Bagchi is a Member of the Study Section and Peer Review Committee of the National Institutes of Health (NIH), Bethesda, MD. Dr. Bagchi has 329 papers in peer reviewed journals, 33 books and numerous patents. He has delivered invited lectures in various national and international scientific conferences, organized workshops, and group discussion sessions. Dr. Bagchi is also a Member of the Society of Toxicology, Member of the New York Academy of Sciences, Fellow of the Nutrition Research Academy, and Member of the TCE stakeholder Committee of the Wright Patterson Air Force Base, OH. Dr. Bagchi is the Associate Editors of the Journal of Functional Foods and the Journal of the American College of Nutrition, and also serving as Editorial Board Member of numerous peer reviewed journals, including Antioxidants & Redox Signaling, Cancer Letters, Toxicology Mechanisms and Methods, The Original Internist, and others
Online resource; title from digital title page (viewed on January 27, 2021)
Subject Nervous system -- Degeneration -- Prevention
Nervous system -- Degeneration -- Diet therapy
Antioxidants -- Therapeutic use
Functional foods -- Therapeutic use
Oxidative stress.
Neurodegenerative Diseases -- prevention & control
Neurodegenerative Diseases -- diet therapy
Antioxidants -- therapeutic use
Functional Food
Oxidative Stress
MEDICAL -- Neurology.
MEDICAL -- Nutrition.
Oxidative stress
Antioxidants -- Therapeutic use
Form Electronic book
Author Kumar, Abhai, editor.
Bagchi, Debasis, 1954- editor.
LC no. 2020033132
ISBN 9780429319310