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Title Neurodegenerative diseases : integrative PPPM approach as the medicine of the future / edited by Silvia Mandel
Published Dordrecht ; London : Springer, 2013


Description 1 online resource
Series Advances in predictive, preventive and personalised medicine ; v. 2
Advances in predictive, preventive and personalised medicine ; v. 2.
Contents Part I. Time for New Guidelines in Handling of Neurodegenerative Disorders: Optimistic Versus Pessimistic Prognosis by Application of PPPM / Silvia Mandel, Olga Golubnitschaja -- Part II. Individual Predispositions in Healthy Vasospastic Individuals: Patient Profiling for Targeted Prevention of "Down-Stream" Pathologies as Cost-Effective Personalised Medicine / Kristina Yeghiazaryan, Josef Flammer, Olga Golubnitschaja -- Idiopathic REM Sleep Behavior Disorder as a Long-Term Predictor of Neurodegenerative Disorders / Stephany Fulda, Mauro Manconi -- New Animal Models of Progressive Neurodegeneration: Tools for Developing Predictive Diagnostics and Identifying Presymptomatic Therapeutic Targets / Amber L. Marriott, Daphne A. Gill, Christopher A. Shaw, R. Andrew Tasker -- Tau Pathology: A Selected View on the Current Status / Illana Gozes -- Part III. The Use of Biomarkers for Prediction and Prevention of Alzheimer's and Parkinson's Diseases / Silvia Mandel, Amos D. Korczyn -- Clinical Trials of AD Delay of Onset: Enrichment by a Prognostic Genetic Biomarker / Iris Grossman, Michael W. Lutz, Donna G. Crenshaw, Ann M. Saunders, Ornit Chiba-Falek -- An Update on CSF Biomarkers of Parkinson's Disease / Peter A. LeWitt, Bertrand R. Huber, Jing Zhang -- Part IV. Glaucomatous Optic Neuropathy: Risk Assessment and Potential Targets for Effective Prevention and Treatments Tailored to the Patient / Olga Golubnitschaja, Kristina Yeghiazaryan, Josef Flammer -- Part V. Toward a Personalized Approach in Amyotrophic Lateral Sclerosis: New Developments in Diagnosis, Genetics, Pathogenesis and Therapies / Beatrice Nefussy, Vivian E. Drory -- Recent Advances in ALS Research: Perspectives for Personalized Clinical Application / Chen Benkler, Daniel Offen, Eldad Melamed, Tamar Amit, Silvia Mandel -- Part VI. Exercise in Multiple Sclerosis -- An Integral Component of Disease Management / Andrea Döring, Caspar F. Pfueller, Friedemann Paul, Jan Dörr -- Bridging the Informatics Gap Between Bench and Bedside: Implications to Neurodegenerative Diseases / Amnon Shabo (Shvo), Maurizio Scarpa -- Part VII. Personalized Medicine in Rare Pediatric Neurometabolic Diseases / Rosella Tomanin, Cinzia Maria Bellettato, Francesca D'Avanzo, Alessandra Zanetti
Summary The economic burden of dementia was estimated as being US$ 604 billion in 2010. Now it is time for new guidelines in handling of neurodegenerative disorders. Optimistic versus Pessimistic Prognosis depends much on diagnostic and treatment approaches which healthcare will preferably adopt in the near future. Current dramatic situation can be significantly improved by the implementation of appropriate early diagnostic, targeted preventive measures and therapies tailored to the person advancing healthcare and enhancing the patient life quality. Neurodegenerative Diseases are pathologies of multi-factorial nature involving interplay of epi/genetic and environmental risk factors. Insights into molecular pathomechanisms will enable to create the most effective neuro-protective strategies and individualised treatment before manifest pathology. Utilization of the advanced integrative medical approach could enable a significant portion of population to reach the 100-year age limit remaining vibrant in excellent physical and mental health as actively contributing members of the society. The crucial role of the integrative approach by PPPM has been acknowledged as priorities by World Health Organization, United Nations and the European Union among others. Extensive efforts of international consortia are essential in the field to consolidate the accumulated expertise and to create population screening, robust diagnostic approaches, effective prevention in groups at high risk and targeted treatments. This book volume "Neurodegenerative Diseases: Integrative PPPM Approach as the Medicine of the Future" is intended to serve as a reference source for basic researchers and healthcare industry involved in the field of neurosciences with a special emphasis on mental health promotion and innovations intended to delay or even prevent neurodegenerative diseases
Bibliography Includes bibliographical references and index
Notes English
Print version record
Subject Nervous system -- Degeneration.
Neurodegenerative Diseases -- diagnosis
Neurodegenerative Diseases -- prevention & control
Precision Medicine -- methods
Preventive Medicine -- methods
treating (health care function)
HEALTH & FITNESS -- Diseases -- Nervous System (incl. Brain)
MEDICAL -- Neurology.
Nervous system -- Degeneration
Form Electronic book
Author Mandel, Silvia
ISBN 9789400758667