| Description |
1 online resource (vii, 682 pages) : illustrations (some color) |
| Contents |
Intro -- Contents -- 1: Introduction to Neuroendocrine Tumors -- 1.1 Introduction -- References -- 2: The Historical Evolution of Neuroendocrine Tumor Disease -- 2.1 Introduction -- 2.2 Concepts of Cell Regulation -- 2.2.1 Identification of Neural and Endocrine Regulatory Systems -- 2.2.2 Recognition of Agents Secreted by Nerves (Neurotransmitters) -- 2.2.3 Feyrter and the Concept of the Diffuse Neuroendocrine System (DNES) -- 2.2.4 Cellular Basis of the Neuroendocrine System -- 2.3 Initial Steps in the Recognition of the Neuroendocrine Tumor System -- 2.3.1 The Role of Oberndorfer |
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2.3.2 The Chemical Basis for Tumor Symptomatology -- 2.3.3 Recognition of Carcinoid Syndrome -- 2.4 Evolution of NETs as an Oncological Discipline -- 2.4.1 Cellular and Secretory Basis -- 2.4.1.1 The Recognition and Role of Somatostatin Receptors (SSTRs) -- 2.4.2 Biomarkers -- 2.4.3 Classification of Tumor Types -- 2.4.4 Imaging -- 2.4.5 Therapy -- 2.5 Tumor Types, Hormonal Release, and Symptomatology -- 2.5.1 Bronchopulmonary Tumors -- 2.5.2 Gastrinoma (Zollinger-Ellison Syndrome) -- 2.5.3 Insulinoma -- 2.5.4 Glucagonoma -- 2.5.5 VIPoma -- 2.5.6 CCK-oma -- 2.5.7 Somatostatinoma |
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2.5.8 Genetic Tumor Syndromes -- 2.5.8.1 Wermer (MEN-1) Syndrome -- 2.5.8.2 Sipple (MEN-2A) Syndrome -- 2.5.8.3 Other Genetic Syndromes -- VHL -- NF1 -- TSC (Tuberous Sclerosis Complex) -- 2.6 CODA -- References -- 3: Neuroendocrine Tumors: Epidemiology -- 3.1 Introduction -- 3.2 Challenges to Neuroendocrine Epidemiology -- 3.3 General Trends -- 3.4 Trends by Geography -- 3.4.1 The United States -- 3.4.2 Europe -- 3.4.3 Asia/Australia -- 3.4.4 Other Regions -- 3.5 Trends by the Primary Subtype and Others -- 3.5.1 The Bronchopulmonary Tract -- 3.5.2 The Small Intestine |
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3.5.3 The Pancreas -- 3.5.4 The Rectum -- 3.5.5 The Appendix -- 3.5.6 Gastric -- 3.5.7 Pediatrics -- 3.5.8 Brain Metastases -- 3.6 Conclusions -- References -- 4: Neuroendocrine Neoplasms (NENs) in Complex Genetic Disorders -- 4.1 Introduction -- 4.2 MEN1 -- 4.3 von Hippel-Lindau Disease -- 4.4 Neurofibromatosis Type 1 -- 4.5 Tuberous Sclerosis Complex -- 4.6 Summary -- References -- 5: Pathological Evaluation and Classification of Digestive Neuroendocrine Neoplasms -- 5.1 The Pathological Diagnosis of Digestive NENs -- 5.1.1 Morphology -- 5.1.2 Immunohistochemistry |
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5.2 The Pathological Classification of Digestive NETs -- 5.2.1 Introduction -- 5.2.2 Basis of the Grading -- 5.2.3 Definitions of the Five Categories of the 2019 WHO Classification -- 5.2.4 The 2017 American Joint Cancer Committee/International Union Against Cancer (AJCC/UICC) Tumor, Node, Metastasis (TNM) -- 5.2.4.1 Introduction -- 5.2.4.2 TNM Staging at Different Digestive Locations (Table 5.3) -- The Pancreas -- The Stomach -- The Duodenum and Ampulla of Vater -- The Jejunum and Ileum -- The Appendix -- The Colon and Rectum |
| Summary |
The second edition of this important textbook covers all aspects of neuroendocrine tumors (NETs), from epidemiology, pathological classification and evaluation, and molecular biology through to diagnostic imaging methods and therapeutic options, including the latest targeted therapies and immunotherapies. Readers will find individual discussion of each of the various types of NET: gastrointestinal, lung, and pancreatic tumors such as insulinomas, gastrinomas, glucagonomas, VIPomas, somatostatinomas, PPomas, and non-functioning pancreatic NETs, as well as medullary thyroid carcinomas, pheochromocytomas, paragangliomas, etc. In addition to NETs, endocrine tumors such as thyroid tumors and adrenocortical tumors are also covered. The contributing authors are internationally recognized experts who bring a wealth of science and experience to the subject. This book will be an invaluable source of information for practicing medical oncologists, surgeons, endocrinologists, gastroenterologists, and pathologists as well as for trainees in these fields |
| Notes |
First edition: 2015 |
| Bibliography |
Includes bibliographical references |
| Notes |
5.3 Specificities of Pathological Diagnosis According to the Different Digestive Locations |
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Description based on online resource; title from digital title page (viewed on October 31, 2024) |
| In |
Springer Nature eBook |
| Subject |
Neuroendocrine tumors -- Diagnosis
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Neuroendocrine tumors -- Treatment
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Internal medicine.
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Surgery.
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Internal Medicine
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General Surgery
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surgery (health care function)
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| Form |
Electronic book
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| Author |
Yalcin, Suayib
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Öberg, Kjell
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| ISBN |
9783031569685 |
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3031569687 |
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