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Book Cover
Author Samkoff, Lawrence M

Title Multiple Sclerosis and CNS Inflammatory Disorders
Published Hoboken : Wiley, 2014


Description 1 online resource (214 pages)
Series NIP- Neurology in Practice
NIP- Neurology in Practice
Contents Multiple Sclerosis and CNS Inflammatory Disorders; Copyright; Contents; Contributors ; Series Foreword ; Preface; 1 Etiology ; Background; Genes; Gender effects: Genetic or biologic?; The role of the environment; Environmental MS risk factors: The major players; Vitamin D; Infection; Smoking; Combining risk factors; Conclusion; Acknowledgment; References; 2 Immunopathogenesis of Multiple Sclerosis ; What does the neuropathology of MS tell us about its pathogenesis?; Gray matter pathology; Multiple sclerosis as an autoimmune disease; Candidates for the self-antigen in multiple sclerosis
Antigen spreadingEpitope spreading; Outside-in versus inside-out?; Lymphocyte trafficking into the CNS ; Role of T cells in MS ; Role of B cells and humoral immunity; Role of microglia and macrophages; Role of other cells: Dendritic cells and astrocytes; Role of cytokines; What might trigger autoimmunity?; Further Reading; 3 Diagnostic Process ; Introduction; Clinical features of MS ; Defining MS; MS disease courses; Common symptoms in MS ; Diagnostic evaluation of MS ; MRI; Revised McDonald criteria for diagnosis of MS ; Ancillary testing in the diagnosis of MS
Differential diagnosis of MS Conclusion; Further Reading; 4 MRI in Diagnosis and Disease Monitoring ; Introduction; MRI at presentation; Lesions; Brain atrophy; Spinal cord; MRI diagnostic criteria; MRI consensus protocol; MRI for monitoring disease and treatment; New lesion activity; Brain atrophy; Limitations; Nonconventional MRI; Magnetization transfer imaging; Magnetic resonance spectroscopy; Susceptibility-weighted imaging; Diffusion-weighted imaging; Perfusion-weighted imaging; Conclusions; Acknowledgments; References; 5 Relapsing MS: Disease Staging and Therapeutic Algorithms
IntroductionWindow; Prognostic factors; Therapy; Initiation; Early window; Late window; Suboptimal response; Intolerance: Lateral therapy; Mild breakthrough: Lateral therapy; Major breakthrough; Combination therapy; Rescue therapy; Escalation; Rapid advancement; Conclusion; Newer oral agents; Further Reading; 6 Progressive MS Treatment Algorithms ; Background; Challenges to clinical trials in progressive MS ; Clinical trials in progressive MS ; Interferon-beta; Glatiramer acetate; Mitoxantrone; Cyclophosphamide; Methotrexate; Methylprednisolone; Other disease-modifying therapies
Monitoring progressive MS in clinical practiceTreatment of progressive MS in clinical practice; Stopping disease-modifying therapy; Neuroprotective strategies; Other treatment considerations; Further Reading; 7 Sex-Determined Issues in Multiple Sclerosis ; Epidemiology of MS and gender; Basic science of sex hormone and chromosome differences seen in MS ; Actions of sex hormones; Gender effects seen in genetics of MS ; Reproductive issues in MS ; Menstrual cycle and menopause; Effects on fertility; Contraceptive issues; Congenital effects; Pregnancy and the MS patient; Epidemiology
Summary Multiple Sclerosis and CNS Inflammatory Disorders is a practical guide to effective care of patients with multiple sclerosis and other neuroimmunologic and CNS inflammatory disorders. It provides the scientific basis of multiple sclerosis including etiology, epidemiology, and pathogenesis. It covers the diagnostic process, the course of the disease and prognosis, and the use of MRI in diagnosis and disease monitoring. Disease-modifying treatment algorithms for relapsing-remitting multiple sclerosis, switching therapy, and progressive multiple sclerosis treatment algorithm
Notes Clinical concerns
Bibliography Includes bibliographical references at the end of each chapters and index
Notes Print version record
Subject Central nervous system -- Diseases -- Immunological aspects
Multiple sclerosis.
Central nervous system -- Immunology.
Central Nervous System Diseases -- immunology
Multiple Sclerosis
Neurogenic Inflammation -- physiopathology
Multiple sclerosis
Form Electronic book
Author Goodman, Andrew D
ISBN 9781118298664