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Book Cover

Title Brain and heart dynamics / Stefano Govoni, Pierluigi Politi, Emilio Vanoli, editors
Published Cham, Switzerland : Springer, [2020]


Description 1 online resource
Contents Intro -- Preface -- Acknowledgments -- Contents -- About the Editors -- About the Section Ediotrs -- Contributors -- Part I: Functional Anatomy and Molecular Basis of the Cardiac-Brain Axis -- 1 Brain-Heart Afferent-Efferent Traffic -- Introduction: Overview of Cardiac Neuronal Control -- Structural and Functional Organization of the Cardiac Nervous System: Peripheral Signaling -- Cardiac Afferent Neurons -- Nodose Ganglion Cardiac Afferent Neurons -- Dorsal Root Ganglion Cardiac Afferent Neurons
Cardiovascular Afferent Neurons in Intrathoracic Extracardiac Ganglia and in Ganglionated Plexi -- Cardiac Motor Neurons -- Cardiac Sympathetic Efferent Neurons -- Cardiac Parasympathetic Efferent Neurons -- Local Circuit Neurons -- Structural and Functional Organization of the Cardiac Nervous System: Central Signaling -- Neuraxial Transduction of Cardiac Pathology -- Neuraxial Transduction of Myocardial Ischemia and Infarction -- Neuraxial Transduction in Heart Failure -- Concluding Summary -- Cross-References -- References -- 2 Brain-Heart Communication -- Introduction
Evidence of Heart-Brain Interactions: The Hardware -- The Signaling Pathways: The Software -- Reflexes and Modulators: A Complex Network Affecting Cardiac Function -- The Baroreceptor Reflex -- Adrenaline -- Angiotensin II -- Natriuretic Peptides -- Neurotrophins -- Conclusions -- Cross-References -- References -- 3 The Cardiorenal Cross Talk -- Introduction -- Measurements of Autonomic Nervous System Activity -- Sympathetic Innervation of the Kidney -- The Sympathorenal Axis in Heart Failure
Consequences of Neurohormonal Axis Activation and Fluid Retention in the Circulatory System, in the Kidney Function, and in th ... -- Conclusion -- References -- 4 Genetic Determinants Affecting the Relationship Between the Autonomic Nervous System and Sudden Death -- Introduction -- Neurocardiac Interactions and Ventricular Arrhythmogenesis -- Anatomy -- Physiology -- Role in Ventricular Arrhythmogenesis -- Genetic Determinants of Autonomic Nervous System Remodeling -- Altered Innervation -- Variants in Human Adrenergic Receptors -- Altered Autonomic Nervous System in Neuronal Disease
Sudden Infant Death Syndrome -- Sudden Unexpected Death in Epilepsy -- Small Fiber Neuropathy -- Genetic Determinants of Inherited Arrhythmia Syndromes Susceptible to Autonomic Nervous System Triggering -- Long QT Syndrome -- Catecholaminergic Polymorphic Ventricular Tachycardia -- Brugada Syndrome -- Takotsubo Cardiomyopathy -- Sudden Cardiac Death in General Population -- Conclusion -- References -- 5 Cognitive Decline in Elderly Patients with Hypertensive Heart Disease -- Introduction -- Hypertension and Hypertensive Heart Disease in the Elderly
Summary Back Cover Text This ambitious and comprehensive manual represents an essential contribution to our current understanding of interactions between heart and brain, a research topic generating growing interest. Despite the increasing awareness that neural mechanisms are the primary cause of cardiac disease and its progression, therapy continues to focus on end-organ protection and does not approach the neural core of the problem. Growing public health problems such as heart failure are still treated with autonomic drugs that are 30-40 years old and simply act on cardiac receptors. However, it has now been shown that the progression of ischemic heart disease to heart failure is mainly due to abnormal central responses to incipient cardiac disease, with neural activation the primary cause rather than the consequence of cardiac remodeling. Written by leading international experts in their respective research areas, it presents a variety of perspectives on the core topic: from social and philosophical to gender-related aspects. Designed for a broad readership, it includes dedicated sections for cardiologists, psychiatrists, neurologists and psychotherapists looking for a more insightful and targeted approach to neuro-cardiovascular disease
Bibliography Includes bibliographical references and index
Notes Online resource; title from digital title page (viewed on September 14, 2020)
Subject Cardiology.
Cardiovascular system -- Diseases.
Brain -- Diseases.
Cardiovascular Diseases
Brain Diseases
Cardiovascular system -- Diseases
Brain -- Diseases
Malalties cardiovasculars.
Malalties cerebrals.
Genre/Form Electronic books
Llibres electrònis.
Form Electronic book
Author Govoni, Stefano, 1950- editor.
Politi, P. L. (Pierluigi), editor.
Vanoli, Emilio, 1954- editor.
ISBN 9783030280086