Title Isoquinolines and beta-carbolines as neurotoxins and neuroprotectants : new vistas In Parkinson's disease therapy / Lucyna Antkiewicz-Michaluk, Hans Rommelspacher, editors

Published New York : Springer, ©2012

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Description 1 online resource (x, 177 pages) Series Current Topics in Neurotoxicity Ser Current Topics in Neurotoxicity Ser Contents 880-01 Two faces of 1,2,3,4-tetrahydroisoquinoline mode of action in the mammalian brain: is it an endogenous neurotoxin or a neuromodulator? -- Isoquinolines as a neurotoxins: action and molecular mechanism -- 1-Methyl-1,2,3,4-tetrahydroisoquinoline -- a potent neuroprotecting agent -- 1-Methyl-1,2,3,4-tetrahydroisoquinoline and addiction: experimental studies -- Beta-carbolines as neurotoxins -- Neuroprotective?-carbolines: occurrence, formation and biodegradation -- Beta-carbolines and neuroprotection: inhibition of monoamine oxidase -- Beta-carbolines increase the efficiency of the respiratory chain in mitochondria -- Antioxidant properties of?-carbolines -- Restoration of neuronal functions in damaged dopamine neurons: in vitro and in vivo studies -- Prospects for new treatment options in neurodegenerative diseases 880-01/(S Two faces of 1,2,3,4-tetrahydroisoquinoline mode of action in the mammalian brain: is it an endogenous neurotoxin or a neuromodulator-- Isoquinolines as a neurotoxins: action and molecular mechanism -- 1-Methyl-1,2,3,4-tetrahydroisoquinoline -- a potent neuroprotecting agent -- 1-Methyl-1,2,3,4-tetrahydroisoquinoline and addiction: experimental studies -- Beta-carbolines as neurotoxins -- Neuroprotective β-carbolines: occurrence, formation and biodegradation -- Beta-carbolines and neuroprotection: inhibition of monoamine oxidase -- Beta-carbolines increase the efficiency of the respiratory chain in mitochondria -- Antioxidant properties of β-carbolines -- Restoration of neuronal functions in damaged dopamine neurons: in vitro and in vivo studies -- Prospects for new treatment options in neurodegenerative diseases Summary Annotation This work reports results from behavioural, neurochemical and molecular experiments which demonstrate a range of TIQs and BCs effects - from their rather mild neurotoxic actions to the important neuroprotective and antiaddictive properties Analysis Medicine Neurosciences Neurochemistry Pharmacy Biomedicine Bibliography Includes bibliographical references and index Subject Neurochemistry. Isoquinoline. Parkinson's disease -- Chemotherapy. Neurotoxic agents. Neuroprotective agents. Carbolines. Parkinson's disease. Symptomatic Parkinson's disease. Neurochemistry Neurotoxins Neuroprotective Agents Isoquinolines Carbolines Parkinson Disease Parkinson Disease, Secondary MEDICAL -- Physiology. SCIENCE -- Life Sciences -- Human Anatomy & Physiology. Symptomatic Parkinson's disease Parkinson's disease Neurotoxic agents Neuroprotective agents Carbolines Isoquinoline Neurochemistry Parkinson's disease -- Chemotherapy Form Electronic book Author Antkiewicz-Michaluk, Lucyna. Rommelspacher, Hans ISBN 9781461415428 146141542X 9781489987549 1489987541

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