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Title Aluminum neurotoxicity : from subtle molecular lesions to neurological diseases / Ankica Jelenković, editor
Published New York : Nova Biomedical, 2016

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Description 1 online resource
Series Neurology--laboratory and clinical research development series
Neurology--laboratory and clinical research development series.
Contents ALUMINUM NEUROTOXICITY FROM SUBTLE MOLECULAR LESIONS TO NEUROLOGICAL DISEASES ; ALUMINUM NEUROTOXICITY FROM SUBTLE MOLECULAR LESIONS TO NEUROLOGICAL DISEASES ; CONTENTS ; PREFACE; Chapter 1 MECHANISTIC ASPECTS OF ALUMINIUM NEUROTOXICITY: OXIDATIVE STRESS AND MITOCHONDRIAL DYSFUNCTIONS ; ABSTRACT ; INTRODUCTION ; NEUROTOXICITY OF ALUMINIUM ; Oxidative Stress in Aluminium Neurotoxicity ; Mitochondrial Oxidative Stress and Dysfunction in Aluminium Neurotoxicity ; Impaired Mitochondrial Energy Metabolism and Oxidative Phosphorylation ; Dysregulated Calcium (Ca2+) Homeostasis
Mitochondria Mediated Apoptosis in Aluminum Neurotoxicity CONCLUSION; REFERENCES ; Chapter 2 ALUMINIUM AND IMBALANCE IN NEUROTRANSMITTER RELEASE ; ABSTRACT ; ABBREVIATIONS; INTRODUCTION ; ALUMINIUM-RELATED NEUROPATHIES ; ALUMINIUM INTERFERES WITH GASEOUS NEUROTRANSMISSION ; Aluminium and H2S Signalling ; Aluminium and CO Synthesis; Aluminium and Nitroxidergic Neurons ; REVERSAL OF PLASMA MEMBRANE NEUROTRANSMITTER TRANSPORTERS IS DYSREGULATED BY ALUMINIUM ; Aluminium and Neurotransmitter Transporters ; Aluminium Effect on Sodium-Dependent Transport of Neurotransmitters
Aluminium Effect on Modulators of Neurotransmitter Transporters Aluminium Effect on Na/K-ATPase and Neurotransmitter Release ; ALUMINIUM REDUCES SNARE-MEDIATED, CALCIUM-DEPENDENT EXOCYTOSIS ; Aluminium Effect on Presynaptic Calcium and Neurosecretion ; Aluminium and the Fusion Pore Properties ; CONCLUSION ; REFERENCES ; Chapter 3 THE RISK OF ALUMINIUM NEUROTOXICITY FOR YOUNG ANIMALS AND HUMANS DUE TO MULTIPLE EXPOSURE OPPORTUNITIES, PARTICULARLY PERINATAL ; ABSTRACT ; INTRODUCTION ; MATERIALS AND METHODS ; Animals ; Experimental Design for Al Treatments
Physical Assessment during Weaning Period Body Weight ; Eye Opening and Hair Appearance ; Neuromotor Maturation Assessment during Weaning Period ; Righting Reflex ; Cliff Avoidance ; Rotating Reflex ; Cognitive Behavioral Assessment ; Active Avoidance Responses ; Morris Water-Maze Test ; Biochemical Studies ; Determination of Monoamines ; Determination of Nonenzymatic OS Indices ; Lipid Peroxides ; Glutathione ; Determination of Enzymatic OS Indices ; Glutathione-S-Transferase ; Catalase ; Superoxide Dismutase ; Statistical Analysis ; RESULTS ; Physical Assessment during Weaning Period
Behavioral Studies Neuromotor Maturation ; Active Avoidance Test ; Morris Water-Maze Task ; Biochemical Studies ; Levels of Monoamines in Forebrain ; Levels of Nonenzymatic OS Indices ; Levels of Enzymatic OS Indices ; DISCUSSION ; CONCLUSION ; ACKNOWLEDGMENT ; REFERENCES; Chapter 4 THE PROTECTIVE AND DOSE-DEPENDENT EFFECTS OF L-NAME IN ALUMINIUM-INDUCED NEUROTOXICITY ; ABSTRACT ; ABBREVIATIONS; INTRODUCTION; NITRIC OXIDE ; Nitric Oxide Synthesis ; Nitric Oxide Actions ; NITRIC OXIDE: MITOCHONDRIA AND GLYCOLYSIS ; THE REACTIVE NITROGEN SPECIES AND NITROSATIVE STRESS
Notes Includes index
Bibliography Includes bibliographical references and index
Notes Online resource, title from PDF title page (Ebsco, viewed on August 31, 2016)
Subject Aluminum -- Toxicology
Aluminum -- Physiological effect.
Neurotoxicology.
Neurotoxicity Syndromes
MEDICAL / Pharmacology
Aluminum -- Physiological effect
Aluminum -- Toxicology
Neurotoxicology
Form Electronic book
Author Jelenković, Ankica, editor.
LC no. 2020679336
ISBN 9781634847629
1634847628