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Title Neurochemistry of abused drugs / edited by Steven B. Karch
Published Boca Raton : CRC Press, ©2008


Description 1 online resource (150 pages) : illustrations
Contents The dopamine transporter and addiction / William M. Meil and John W. Boja -- Neurochemistry of nicotine dependence / Darlene H. Brunzell -- Neurochemical substrates of habitual tobacco smoking / Irina Esterlis, Suchitra Krishnan-Sarin, and Julie K. Staley -- Neurochemical and neurobehavioral consequences of methamphetamine abuse / Colin N. Haile -- Neurochemical adaptations and cocaine dependence / Kelly P. Cosgrove and Julie K. Staley -- Neuropsychiatric consequences of chronic cocaine abuse / Deborah C. Mash -- Neurobiology of 3,4-methylenedioxymethamphetamine (MDMA or "ecstasy") / Michael H. Baumann and Richard B. Rothman
Summary Beginning with a detailed look at individual drugs and their effects on the brain, "Neurochemistry of Abused Drugs" considers the changes in neurotransmitter levels and discusses the relationship of these changes to the nature and phenomenon of addiction. New studies highlight the addictive capacity of nicotine as well as introduce novel compounds that may aid in tobacco cessation. Chapters examine nicotine dependant neuroplasticity and the various neurochemical substrates that support and promote addiction including cholinergic, dopaminergic, and GABAergic adaptations.; The book also offers detailed information on the neurochemical and neurobehavioral consequences of MDMA, methamphetamine, and cocaine use. Recent discoveries on the neurotransmitter systems involved in each of these drugs reveal new therapeutic targets for alleviating addiction including ibogaine, and GABA and glutamate receptors. Extensively referenced and citing numerous up-to-date studies, this book provides unparalleled insight into the action and potential inhibition of drugs of abuse
Bibliography Includes bibliographical references and index
Notes Print version record
Subject Drug abuse -- Pathophysiology
Drugs of abuse -- Physiological effect.
Drugs of abuse.
Substance-Related Disorders -- physiopathology
Brain -- drug effects
Neurotoxicity Syndromes -- etiology
Substance-Related Disorders -- complications
Illicit Drugs
HEALTH & FITNESS -- Diseases -- Nervous System (incl. Brain)
MEDICAL -- Neurology.
Drugs of abuse.
Drug abuse -- Pathophysiology.
Drugs of abuse -- Physiological effect.
Genre/Form Electronic books
Form Electronic book
Author Karch, Steven B.
ISBN 9781420054422