| Description |
1 online resource (323 pages) : illustrations (some color) |
| Series |
Frontiers in neuroscience |
|
Frontiers in neuroscience (Boca Raton, Fla.)
|
| Contents |
Front cover; Foreword and Scope; Acknowledgments; Editor; Contributors; Table of Contents; 1; Neuroscience Hypotheses and Translation into Neurosurgery Practice; 1.1 Introduction; 1.1.1 Concept of Translational Neuroscience; 1.1.2 Translational Neurosurgery versus Translational Neuroscience; 1.1.3 Examples of Translational Products; 1.2 Categories of Neurosurgery Advances; 1.3 Critical Questions in Translational Neurosurgery; 1.3.1 When Is Preclinical Data Sufficient to Proceed to Human Experimentation?; 1.3.2 Who Is Involved with Translational Neurosurgery? |
|
1.3.3 Mechanisms of Translational Neurosurgery: University and Corporate Involvement1.3.4 Device Development Process; 1.3.5 Guidelines for Efficacious Treatment Schemes; 1.4 Outline of Topics of Neurosurgery Advances; 1.5 Levels of Nervous System Functioning: Cellular to Systems; 1.6 Conclusions; References; 2; Clinical Prospects for Neural Grafting Therapy for Cortical Lesions; 2.1 Introduction; 2.2 Graft Cell Integration: Preclinical Studies; 2.2.1 Graft Cell Labeling; 2.2.2 Graft Cell Survival; 2.2.3 Graft Cell Migration and Dispersion; 2.2.4 Synaptic Graft-Host Interactions |
|
2.2.5 Preclinical Graft Cell Sources2.3 Clinical Contexts; 2.3.1 Cortical Lesions: Early Postlesion Grafting; 2.3.2 Cortical Lesions: Late Postlesion Grafting; 2.3.3 Neural Grafts for Treatment of Epilepsy; 2.3.4 Neural Grafts for Treatment of Stroke; 2.3.5 Neural Grafts for Treatment of Severe Head Injury; 2.4 Clinically Appropriate Graft Cell Sources; 2.4.1 Embryonic Neural Cells; 2.4.2 Cultured Cell Lines; 2.4.3 Non-Neural Cells; 2.4.4 Pluripotent Progenitor and Stem Cells; 2.5 Side Effects of Neural Grafts; 2.6 Clinical Applicability and Challenges in Translation; References; 3 |
|
Advances in Treatment of Spinal Cord and Peripheral Nerve Injury3.1 Introduction; 3.2 Spinal Cord Neuroprotection; 3.2.1 Maturation of Spinal Cord Injury; 3.2.2 Secondary Neuroprotection Treatment Schemes; 3.3 Spinal Cord Regeneration; 3.3.1 Enhancement of Axonal Regrowth; 3.3.2 Cellular or Inert Bridges and Neural Grafting; 3.4 Rehabilitation; 3.5 Neuroprosthetics; 3.6 Combination Therapies; 3.7 Peripheral Nerve Repair; 3.7.1 Nerve Guide Tubes; 3.7.2 Enhancement of Specificity of Regeneration; 3.8 Conclusions; References; 4 |
|
Cellular Brain Ischemia and Stroke: Neuroprotection, Metabolism, and New Strategies for Brain Recovery4.1 Introduction; 4.2 Types of Strokes and Cerebral Ischemia Events; 4.3 Cellular Consequences of Stroke; 4.4 Problems in Translation of Stroke Treatments from Bench to Bedside; 4.4.1 Animal Models of Ischemic Stroke; 4.4.2 Time Windows of Treatment; 4.4.3 Early vs. Late Outcome Definition; 4.4.4 Regional Differences in Target Areas of Brain; 4.4.5 Pharmacokinetics, Safety Issues, and Appropriate Dosing; 4.4.6 Clinical Outcome Measures and Statistical Issues with Clinical Trials |
| Summary |
Focusing on how increased understanding of brain function affects clinical neuroscience, this incisive text explores the interface between neuroscience and clinical neuroscience advances by examining the hypotheses that drive this evolution. The author reviews the relevant underpinnings of new neurosurgical techniques, treatments, and conceptual approaches, which are likely to shape clinical neuroscience over the next decade. A critical aspect of this rational approach is to underscore what needs to be done in each field, potentially leading to further study and improvements |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Print version record |
| Subject |
Nervous system -- Surgery.
|
|
Neurosurgery -- trends
|
|
Neurosurgical Procedures -- trends
|
|
MEDICAL -- Surgery -- Neurosurgery.
|
|
Nervous system -- Surgery
|
| Form |
Electronic book
|
| Author |
Turner, Dennis A
|
| ISBN |
0203503996 |
|
9780203503997 |
|
9780429210990 |
|
042921099X |
|
