| Description |
1 online resource (456 pages, 12 unnumbered pages of plates) : illustrations (some color) |
| Contents |
Neural Precursor Cells and Toxicant Action: Addressing the Analysis of Low-Level Toxicant Exposure, M. Noble; The Role of Microglia in Neurotoxicity, W.J. Streit; Schwann Cell Neurotoxicity, A.D. Toews, G.J. Harry, and P. Morell; Function of Astrocyte Cytochrome P450 in Control of Xenobiotic Metabolism, R.P. Meyer, B. Volk, and R. Knoth; The Reactive Astrocyte, M.D. Norenberg; Molecular Mechanisms of Glutamate and Glutamine Transport in Astrocytes, S. Bröer; Neuronal-Astrocytic interactions (TCA cycling), U. Sonnewald, A. Schousboe, and H.S. Waagepetersen; Cytokines in Neuronal-Glial Interaction, B. Viviani and M. Marinovich; Signaling Mechanisms Underlying Toxicant-Induced Gliosis, K. Sriram and J.P. O'Callaghan; Astrocyte Cellular Swelling: Mechanisms and Relevance to Brain Edema, H. Pasantes-Morales and R. Franco; Astrocyte Metallothioneins and Physiological and Pathological Consequences to Brain Injury, J |
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Hidalgo; Peripheral Benzodiazepine Receptor Imaging in Glial Cells: Molecular Sensors of Brain Pathology, T.R. Guilarte; Astrocyte-Neuronal Interaction and Oxidative Injury: Rose of Glia in Neurotoxicity, V. Chock and R. Giffard; Astrocytes in Acute Energy Deprivation Syndromes, E.S. Williams, A.D. Phelka, D.E. Ray, and M.A. Philbert; The Role of Multiple Drug Resistance in Neuroglial Survival: Lessons from Human Epileptic Brain, K.M. Kight, K.L. Hallene, G. Dini, and D. Janigro; Pathogenesis of HIV Associated Dementia and Multiple Sclerosis: Role of Microglia and Astrocytes, A. Minagar, P. Shapshak, and J.S. Alexander; Possible Detrimental Role of Astrocytic Activation During the Subacute Phase of Permanent Regional Cerebral Ischemia in the Rat, T. Asano, N. Tateishi, and T. Mori; Role of Microglia and Astrocytes in Alzheimeŕs Disease, P. Schubert and S |
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Ferroni; Developmental Efficts of Xenobiotics on Thyroid Hormone Regulation in the CNS with Emphasis on Glial Function, O.P. Soldin; Astrocytes in Ammonia Neurotoxicity: A Target, A Mediator, and a Shield, J. Albrecht; Alcohol and Glia in the Developing Brain, L.G. Costa, K. Yagle, A. Vitalone, and M. Guizzetti; Zinc Homeostatic Proteins and Glia, W.F. Silverman; Iron and Glial Toxicity, J.R. Connor, X. Zhang, and P. Cheepsunthorn; Astroglia and Methylmercury Neurotoxicity, G. Shanker, T. Syversen, J.L. Aschner, and Michael Aschner; Manganese, V.A. Fitsanakis, S.J. Garcia, and M. Aschner; Astroglia and Lead Neurotoxicity, E. Tiffany-Castiglioni and Y. Qian; Role of Glia in MPTP Toxicity and Parkinson's Disease, L.G. Costa and M. Aschner |
| Summary |
Gial cells represent more than mere passive cytoskeletal support elements of the central and peripheral nervous system. A reciprocal relationship exists between neurons and glia that is vital for mutual differentiation, development, and functioning of both cell types. It also has become apparent that perturbations in glial function may lead to deleterious consequences in juxtaposed neurons. It is therefore possible that neuronal damage induced by chemicals or neuropathic disease involves dissociation of glial-neuronal interactions. This book brings together experts in the neurosciences to provide a more complete understanding of the effects of chemicals on nervous system function. It explores potential sites of glial-neuronal interactions both in the central and peripheral nervous system, focusing on potential sites of neurotoxicant actions. Text introduces basic aspects of neuroscience, the first step toward understanding the mechanisms at work in normal physiology. The ways in which these processes are disturbed in pathological conditions are discussed. Distinguished authors examine the functional interactions between glial cells and neurons during development, adulthood, and senescence. The roles of glia in the normal CNS and PNS are described. The book offers specific, in-depth examples of directly (via diffusive and cell surface signals) or indirectly (via effects on the extracellular fluid or the blood-brain barrier) mediated glial neurotoxicity. This reference includes different techniques, conceptual frameworks, and approaches that are currently used in the study of the role of glia in neurotoxicity |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Print version record |
| Subject |
Neurotoxicology.
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Neuroglia.
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Neuroglia -- drug effects
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Nervous System Diseases -- physiopathology
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Neuroglia -- physiology
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Neurotoxins -- adverse effects
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Neuroglia
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HEALTH & FITNESS -- Diseases -- General.
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MEDICAL -- Clinical Medicine.
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MEDICAL -- Diseases.
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MEDICAL -- Evidence-Based Medicine.
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MEDICAL -- Internal Medicine.
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Neuroglia
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Neurotoxicology
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| Form |
Electronic book
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| Author |
Aschner, Michael, 1955-
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Costa, Lucio G., 1954-
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| ISBN |
1420039741 |
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9781420039740 |
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