Title The chemical languages of the nervous system : history of scientists and substances / Josef Donnerer, Fred Lembeck

Published Basel ; New York : Karger, ©2006

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Description 1 online resource (ix, 228 pages) : illustrations Contents Introduction -- Otto Loewi -- Otto Lowei -- introductory remarks -- Autobiographic sketch / O. Loewi -- Otto Lowei 1873-1961 / H.H. Dale -- Otto Loewi / F. Brücke -- Lowei's time in Graz -- Comment on Lowei's dream -- An overlooked parallel to Kelulé's dream: the discovery of the chemical transmission of nerve impulses by Otto Loewi / U. Weiss and R.A. Brown -- The Loewi family's way to the new world -- Comment on the film: Nobelpreisträger Otto Lowei -- Henry Hallett Dale -- Henry Hallett Dale -- introductory remarks -- Henry Hallett Dale 1875-1968 / W. Feldberg -- Fifty years after the Nobel Prize award to H.H. Dale and Otto Loewi / G.B. Koelle Religious reflections of Dale and Loewi -- Wilhelm Feldberg -- Wilhelm Feldberg -- introductory remarks -- The early history of synaptic and neuromuscular transmission by acetylcholine: reminiscences of an eye witness / W. Feldberg -- Substances -- From the history of scientists to that of neurotransmitter substances -- A substance isolated from brain, synthesized and called neurin: acetylcholine -- Adrenaline, noradrenaline and dopamine: the catecholamines. From the 'acceleransstoff' to adrenaline, noradrenaline and dopamine Enteramine and serotonin: two names and three functions of 5-hydroxytryptamine -- Histamine: one substance and three functions -- The amino acid transmitter family --A cloud of peptides -- Substance P -- Calcitonin gene-related peptide -- Neuropeptide Y, galanin and vasoactive intestinal polypeptide -- Opioid peptides -- Nitric oxide -- ATP and adenosine -- Peripheral neurogenic stimulators -- Neurotransmission in the central nervous system -- From transmitter to receptor: progress within 50 years -- Subject index Summary A Karger 'Publishing Highlights 1890-2015' title <br />Neurochemical transmission accounts for the majority of information transfer both in the central and peripheral nervous system. The initial findings centred around the experimental work of the two Nobel Prize winners Sir Henry H. Dale and Otto Loewi as well as Wilhelm Feldberg. Their historical findings opened the door to further investigations and extended the list of neurotransmitters to many others such as amino acids, peptides, purines and nitric oxide. In the first part, the publication provides fascinating insights into the life of the three scientists. Their personality and scientific approach are presented through autobiographical sketches and personal memories by authors. Various comments and details of the atmosphere in the laboratory complete the picture of the conditions at the time. The second part is dedicated to the history of the substances, such as neurotransmitters, their antagonists and analogues. The stories of these substances are presented to the reader in a succinct way, including many anecdotes and unusual events on the way to their therapeutic application Bibliography Includes bibliographical references and index Notes Print version record Subject Loewi, Otto, 1873-1961. Dale, Henry H. (Henry Hallett), Sir, 1875- Feldberg, W. S SUBJECT Loewi, Otto, 1873-1961 Dale, Henry H (Henry Hallett), Sir, 1875-1968 Feldberg, W. S Feldberg, W. S. fast Loewi, Otto, 1873-1961 fast Subject Neurotransmitters -- History Neuroscientists -- Biography Biochemists -- Biography Neurochemistry. Neurotransmitter Agents -- history Neurochemistry Neurochemistry Biochemists Neuroscientists Neurotransmitters Farmacochemie. Centraal zenuwstelsel. Neurologie. Neurotransmitters. Neuropeptiden. Neurotransmitter -- Forschung -- Geschichte. Genre/Form Biographies History Biographies. Biographies. Form Electronic book Author Lembeck, Fred S. Karger (Firm) ISBN 9783318012699 3318012696

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