""Environmental Neurotoxicology""; ""Copyright""; ""Preface""; ""Contents""; ""Executive Summary""; ""MAGNITUDE OF THE PROBLEM""; ""NEUROTOXICITY TESTING""; ""SURVEILLANCE AND EPIDEMIOLOGIC STUDIES IN ENVIRONMENTAL NEUROTOXICOLOGY""; ""BIOLOGIC MARKERS IN ENVIRONMENTAL NEUROTOXICOLOGY""; ""NEUROTOXICITY RISK ASSESSMENT""; ""1 Introduction: Defining the Problem of Neurotoxicity""; ""NEUROLOGIC RESPONSES TO ENVIRONMENTAL TOXICANTS""; ""MAGNITUDE OF THE PROBLEM OF NEUROTOXICITY""; ""DETECTION AND CONTROL OF EXPOSURE TO NEUROTOXICANTS""; ""SCOPE OF THIS REPORT""
""2 Biologic Basis of Neurotoxicity""""CELLULAR ANATOMY AND PHYSIOLOGY""; ""Structure of the Neuron""; ""The Nerve Impulse""; ""Synaptic Transmission""; ""Synaptic Messengers""; ""GENERAL ASPECTS OF NERVOUS SYSTEM STRUCTURE AND FUNCTION""; ""Metabolism""; ""Blood-Brain Barrier""; ""Development""; ""Plasticity""; ""Trophic Interactions""; ""VULNERABILITY OF THE NERVOUS SYSTEM TO CHEMICAL TOXICANTS""; ""Complexity of Structural and Functional Integration""; ""Limitations on Repair""; ""Accessibility to Lipid-Soluble Toxicants""; ""Dependence on Glucose""; ""Axonal Transport""
""Synaptic Transmission""""Ion Channels""; ""EXAMPLES OF NEUROTOXIC MECHANISMS""; ""Pyrethroids""; ""γ-Diketones""; ""MPTP""; ""SUMMARY""; ""3 Biologic Markers in Neurotoxicology""; ""CONCEPTS AND DEFINITIONS""; ""Biologic Markers of Exposure""; ""Biologic Markers of Effect""; ""Biologic Markers of Susceptibility""; ""VALIDATION OF BIOLOGIC MARKERS""; ""USE OF BIOLOGIC MARKERS IN RISK ASSESSMENT""; ""SUMMARY""; ""4 Testing for Neurotoxicity""; ""APPROACH TO NEUROTOXICITY TESTING""; ""Difficulties in Neurotoxicity Testing""; ""The Testing Strategy""
""Characteristics of Tests Useful for Screening""""Application of the Screen and Later Tiers""; ""CURRENT METHODS BASED ON STRUCTURE-ACTIVITY RELATIONSHIPS""; ""CURRENT IN VITRO PROCEDURES""; ""Biochemical Assays""; ""Tissue Culture""; ""Plausibility of an In Vitro Screening Battery""; ""CURRENT IN VIVO PROCEDURES""; ""Behavioral Assessment""; ""Functional Observational Batteries""; ""Motor Activity""; ""Schedule-Controlled Operant Behavior""; ""Specialized Tests of Neurologic Function""; ""Motor Function""; ""Sensory Function""; ""Learning and Memory""; ""Neurophysiologic Procedures""
""Nerve-Conduction Studies""""Sensory Evoked Potentials""; ""Electroencephalography""; ""Neurochemical Procedures""; ""Neuroendocrine Interactions""; ""Neuropathology""; ""Imaging Procedures""; ""Modifying Variables""; ""Age at Exposure""; ""Age at Testing""; ""Sex""; ""Genetic Differences""; ""CURRENT REGULATORY APPROACHES""; ""STRATEGIES FOR IMPROVED NEUROTOXICITY TESTING""; ""Screening""; ""Validation""; ""Priority-Setting and Implementation""; ""Research Needs""; ""5 Surveillance to Prevent Neurotoxicity in Humans""; ""Need for Surveillance""; ""NEUROBEHAVIOURAL TEST BATTERIES""
