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Title Nicotinic receptors / Robin A.J. Lester, editor
Published New York : Humana Press/Springer, [2014]


Description 1 online resource
Series The Receptors ; 26
Receptors (Series) ; 26
Contents Foreword; Preface; Contents; Contributors; Chapter 1: On the℗ Discovery of℗ the℗ Nicotinic Acetylcholine Receptor Channel; 1 Before the℗ Receptor: A Tale of℗ Two Alkaloids; 2 Determination of℗ the℗ Site of℗ Action of℗ Curare (1840-1900); 3 The Receptor Entity (1905); 4 Quantitative Analysis of℗ Receptor Function (1900-1950); 5 More Complete Receptor Mechanisms (1950- ); 6 Single nAChR Transitions and℗ Synaptic Transmission (1970- ); 7 The Receptor Protein (1970- ); 8 Receptor Cloning and℗ Structure (1980- ); 9 Summary; References; Chapter 2: Molecular Structure, Gating, and℗ Regulation; 1 Introduction
2 Atomic-Resolution Structural Analysis of℗ Gating2.1 The Structural Basis of℗ Gating at the℗ Ligand-Binding Sites; 2.2 Binding Site Inequality; 2.3 The Structural Basis of℗ Gating at the℗ Channel; 2.4 Structural Basis of℗ Coupling Ligand Binding to℗ Channel Gating; 2.5 Desensitization; 2.6 Summary of℗ Structural Data; 3 Functional Analysis of℗ Gating; 3.1 Energetics and℗ Linear Free Energy Analysis of℗ Gating; 3.2 Where Is the℗ Actual Gate?; 3.3 The Flip Side of℗ Activation; 3.4 Desensitization as℗ a℗ Gating Phenomenon; 3.5 The Intermediate State of℗ Desensitization; 3.6 The Role of℗ Multiple Binding Sites
4 Summary, Conclusions, and℗ Unresolved IssuesReferences; Chapter 3: Molecular Underpinnings of℗ Neuronal Nicotinic Acetylcholine Receptor Expression; 1 Introduction; 2 Transcriptional Regulation of℗ nAChR Subunit Genes; 2.1 CHRNA2; 2.2 CHRNA3; 2.3 CHRNA4; 2.4 CHRNA5; 2.5 CHRNA6; 2.6 CHRNA7; 2.7 CHRNA8; 2.8 CHRNA9 and℗ CHRNA10; 2.9 CHRNB2; 2.10 CHRNB3; 2.11 CHRNB4; 2.12 The CHRNA5/A3/B4 Gene Cluster; 3 miRNA Regulation of℗ nAChR Subunit Gene Expression; 4 Epigenetic Regulation of℗ nAChR Subunit Gene Promoters; 5 Nicotine and℗ nAChR Expression; 6 Summary; References
Chapter 4: Presynaptic Nicotinic Acetylcholine Receptors: Subtypes and℗ Functions1 Introduction; 2 Presynaptic nAChR-Mediated 86Rb+ Efflux; 2.1 Initial Characterization of℗ nAChR-Mediated 86Rb+ Efflux; 2.2 Desensitization of℗ nAChR-Mediated 86Rb+ Efflux; 2.3 Using Mutant Mice to℗ Identify nAChR Subtypes Mediating 86Rb+ Efflux; 2.4 nAChR-Mediated 86Rb+ Efflux Following Chronic Nicotine Treatment; 2.5 Summary; 3 Presynaptic nAChR-Mediated Neurotransmitter Release; 3.1 Dopamine; 3.2 nAChR Subtypes in℗ Striatum and℗ Nucleus Accumbens; 4 Physiological Role of℗ Presynaptic nAChR
5 Gain-of-Function Mutations6 Effect of℗ Chronic Nicotine Treatment; 7 Variable Desensitization; 8 Dopamine Release in℗ Other Brain Regions; 9 GABA; 10 Glutamate; 11 Norepinephrine; 12 Acetylcholine; 13 Summary and℗ Future Directions; References; Chapter 5: Functional Distribution and℗ Regulation of℗ Neuronal Nicotinic ACh Receptors in℗ the℗ Mammalian Brain; 1 Introduction; 2 Ligand Binding and℗ Gating; 3 Regional Expression and℗ Functional Assembly of℗ Various Subtypes in℗ the℗ Brain; 4 Regulation by Signal Transduction Cascades and℗ Lipid℗ Rafts; 5 Regulation of℗ Gene Transcription
Summary A comprehensive overview of nicotinic receptors that addresses their history from crystal structure to behavior as well as their implications in disease and potential as therapeutic targets. It includes background information on all subtypes of nicotinic receptors, the most recent information on the distribution throughout the nervous system, and discussion of their implications in learning and memory, addiction, and neurological and psychiatric disease such as Alzheimer's and Parkinson's. Takes advantage of several recent developments in the fields of optogenetics, viral expression, and gene analysis to focus on current knowledge on the functional aspects of nicotinic receptors
Analysis biomedische wetenschappen
Medicine (General)
Geneeskunde (algemeen)
Notes Print version record./online resource; title from title page (WEBSITE NAME, viewed Month DD, YYYY)
Subject Nicotinic receptors.
Receptors, Nicotinic
MEDICAL -- Physiology.
SCIENCE -- Life Sciences -- Human Anatomy & Physiology.
Nicotinic receptors
Form Electronic book
Author Lester, Robin A. J., editor
ISBN 9781493911677