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Title Nitric oxide : biology and pathobiology / edited by Louis J. Ignarro
Edition 2nd ed
Published London : Academic, 2010


Description 1 online resource
Contents Section I. Chemical Biology -- Determinants of Nitric Oxide Chemistry: Impact of Cell Signaling Processes -- Nitric oxide redox biochemistry in lipid environments -- Mechanisms and biological consequences of peroxynitrite-dependent protein oxidation and nitration -- Systems Approaches to Unraveling Nitric Oxide Response Networks in Prokaryotes -- Section II. Principles of Biology -- A. Nitric Oxide Synthases -- Uncoupling of endothelial NO synthase (eNOS) in cardiovascular disease and its pharmacological reversal -- Tetrahydrobiopterin: An essential cofactor for Nitric Oxide Synthases and Amino Acid Hydroxylases -- Regulation of the expression of inducible nitric oxide synthase -- Molecular Regulation of Inducible Nitric Oxide Synthase -- B. Guanylate Cyclase and Cyclic GMP --Soluble Guanylate Cyclase: Allosteric Activation and Redox Regulation -- C. Nitric Oxide Signaling -- Untargeted Discovery of NO-modified Proteins -- Fatty Acid Transduction of Nitric Oxide Signaling: Cyclooxygenases, Lipoxygenases and Nitro-Fatty Acids -- Nitric Oxide Signaling in Vascular Cells is Regulated through CD47 by Thrombospondin-1 -- The Regulation of Cell Energetics and Mitochondrial Signaling by Nitric Oxide -- D. Regulation of Nitric Oxide Production -- Nitric oxide-asymmetric dimethylarginine system in endothelial cell senescence -- E. Nitric Oxide and Remodeling -- The Role of Nitric Oxide in Apoptosis and Autophagy: Biochemical and Computational Studies -- F. Nitrite and Nitrate -- NO formation from inorganic nitrate and nitrite -- Mechanisms of nitrite reduction in ischemia in the cardiovascular system: therapeutic potential -- Nitrite Therapy for Ischemic Syndromes -- Nitrite and heme globins: Reaction mechanisms and physiological targets -- Section III. Principles of Pathobiology -- A. Nitric Oxide and Cardiovascular Function -- Nitric Oxide in Vascular Damage and Regeneration -- Free radicals as atherosclerotic risk-The relation of NO- -- The role of oxidative stress in endothelial dysfunction and vascular inflammation -- B. Pathophysiological Mechanisms of Nitric Oxide -- Nitric oxide, oxidative stress, immune response and critical care -- Reactive Metabolites of Oxygen and Nitrogen in Liver Ischemia and Reperfusion Injury -- Nitric oxide in airway inflammation -- Novel therapeutic applications of nitric oxide (NO) in the inhibition of tumor malignancy and reversal of resistance
Summary Nitric oxide (NO) is a gas naturally found in the body that conveys information between cells. In the last decade researchers have found that NO is a signaling molecule of key importance for the cardiovascular system, regulating blood pressure and blood flow to different organs. In addition, discoveries surrounding nitric oxide's role as a principal neurotransmitter moderating erectile function, a pathophysiological negotiator and messenger in inflammation, and a weapon against infections have increased research attention across the fields of biochemistry, chemistry, molecular biology, gene therapy, cell biology, immunology, pharmacology, neuroscience, and physiology. Edited by Nobel Laureate Louis J. Ignarro Up-to-date therapeutic implications of nitric oxide research Authored by world experts on nitric oxide Detailed research of the biochemistry and synthesis of nitric oxide
Analysis stikstofoxide
nitric oxide
signal transduction
Bibliography Includes bibliographical references and index
Notes Print version record
Subject Nitric oxide.
Nitric oxide -- Therapeutic use
Nitric oxide -- Physiological effect
Nitric Oxide -- physiology
Nitric Oxide -- therapeutic use
MEDICAL -- Biochemistry.
Nitric oxide.
Nitric oxide -- Physiological effect.
Biologisches System
Form Electronic book
Author Ignarro, Louis J.
ISBN 9780123738660