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Title Nitric oxide donors : novel biomedical applications and perspectives / edited by Amedea Barozzi Seabra
Published London : Academic Press, [2017]


Description 1 online resource : illustrations
Contents 880-01 Front Cover; Nitric Oxide Donors; Copyright Page; Contents; List of Contributors; 1 Nitric Oxide Derivative Ruthenium Compounds as NO-Based Chemotherapeutic and Phototherapeutic Agents; Introduction; Nitrosyl Ruthenium Complexes as NO Delivery Agents; Basic physical and chemical properties of some NO derivative species; Ruthenium-Nitrogen Oxide Derivatives as NO Sources; Nitrosyl Ruthenium Complexes as NO Delivery Agent by Reduction Process; Synergistic effect between ruthenium complex and nitric oxide as a tool to increase cytotoxicity
880-01/(S Structural Features of Nitrate NO-NSAIDsSecond-Generation NO-NSAIDs; NO-Releasing Coxibs; Cancer Prevention with NO-NSAIDs; Molecular Targets of NO-ASA in Cancer; Cell Kinetics; NF-κB; Wnt/β-Catenin Signaling; Nitric Oxide Synthase; COX-2; Peroxisome Proliferator-Activated Receptor δ (PPARδ); Mitogen-Activated Protein Kinase (MAPK); Xenobiotic Metabolizing Enzymes; Oxidative Stress; Modulation of Proinflammatory Cytokines; S-Nitrosylation; Biological Actions of the Spacer in NO-ASA; Diazeniumdiolate-Based NO-Releasing Compounds; NONO-NSAIDs; HNO-NSAIDs; JS-K and PABA/NO; NOSH-NSAIDs
Photo-Nitric Oxide Release Promoted by Ruthenium ComplexesImage: A Powerful Tool to Elucidate Cytotoxicity Mechanisms of No Donor Agents Based on Ruthenium Complexes; Liposome delivery; Conclusion; References; 2 Nitric Oxide Donors for Treating Neglected Diseases; Neglected Diseases; Why Using NO Donors to Treat Neglected Diseases?; Malaria; NO and Malaria; NO Donors and Malaria; Leishmaniasis; NO and Leishmaniasis; NO Donors and Leishmaniasis; Trypanosomiasis; NO and Trypanosomiasis; NO Donors and Trypanosomiasis; Schistosomiasis; NO Donors and Schistosomiasis; Tuberculosis
NO Donors and TuberculosisDengue Fever; NO Donors and DF; Blastocystis Hominis Infection; NO Donors and Blastocystis homini Infection; NO Donors and Lymphatic Filariasis; NO Donors and Other Neglected Diseases; Mechanisms of Action of NO Against Pathogens That Cause Neglected Diseases; Final Remarks: Challenges and Perspectives; Acknowledgments; References; 3 Nitric Oxide-Donating Devices for Topical Applications; Introduction; Nitric Oxide (NO) Synthases; Nitrite Reductases; NO's Role in the Body; NO's Role in Wound Healing; Complications Resulting from Attenuation of NO Production
NO Releasing Biomedical DevicesAgents for Regulating NO; NO Donors; Donor Carriers; Topical Applicators; Chitosan, a Versatile Biopolymer; Copper Chitosan as an NO Donor; Topical Copper Chitosan Particles; Conclusion; References; 4 Nitric Oxide Donors and Therapeutic Applications in Cancer; Introduction; Cellular Actions of NO; Cancer as an Inflammatory Disease; NSAIDs Protect Against Cancer, Proof of Principle; Side Effects Associated with NSAID Use; NO-Based Compounds as Cancer Therapeutics; Nitric Oxide-Releasing NSAIDs (NO-NSAIDs) and the Rationale for Their Development
Summary Nitric Oxide Donors: Biomedical Applications and Perspectives presents the current state of art, challenges and innovations in the design of therapeutics nitric oxide donors with great impact in several aspects of human physiology and pathophysiology. Although considerable innovative progress has been achieved using Nitric Oxide donors in biomedical applications, certain drawbacks still need to be overcome to successfully translate these research innovations into clinical applications. This book encompasses several topics on nitric oxide such as its sources and biological properties; its performance in the cardiovascular and neurologic systems, in the human skin and its application in the treatment of neglected diseases, neurodegenerative disorders, and cancer. Additionally, it covers its role in inflammation and immunity, penile erection function, photodynamic therapy, antimicrobial activities. It also discusses the future of nitric oxide donors in combination with other therapeutic drugs, in implantable sensors, and nitric oxide releasing hydrogels and medical devices for topical applications. The book is a valuable source for researchers on different areas of biomedical field who are interested in the improvements that these molecules can make in the treatment of several conditions
Bibliography Includes bibliographical references and index
Notes Vendor-supplied metadata
Subject Nitric oxide -- Therapeutic use
Pharmaceutical chemistry.
Nitric oxide.
Nitric Oxide Donors -- pharmacology
Chemistry, Pharmaceutical
Nitric Oxide
Nitric Oxide Donors -- therapeutic use
SCIENCE -- Life Sciences -- Biochemistry.
Nitric oxide.
Pharmaceutical chemistry.
Genre/Form Electronic books
Form Electronic book
Author Seabra, Amedea Barozzi, editor
ISBN 9780128134597