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Title Cyclic nucleotide signaling / edited by Xiaodong Cheng
Published Boca Raton : CRC Press LLC, [2015]


Description 1 online resource
Series Methods in signal transduction series
Methods in signal transduction.
Contents Chapter 1. Discovery of small molecule EPAC specific modulators by high-throughput screening / Xiaodong Cheng, Tamara Tsalkova, and Fang Mei -- chapter 2. Cyclic nucleotide analogs as pharmacological tools for studying signaling pathways / Elke Butt -- chapter 3. High-throughput FRET assays for fast time-dependent detection of cyclic AMP in pancreatic B cells / George G. Holz, Colin A. Leech, Michael W. Roe, and Oleg G. Chepurny -- chapter 4. Assessing cyclic nucleotide recognition in cells : opportunities and pitfalls for selective receptor activation / Rune Kleppe, Lise Madsen, Lars Herfindal, Jan Haavik, Frode Selheim, and Stein Ove Døskeland -- chapter 5. Monitoring cyclic nucleotides using genetically encoded fluorescent reporters / Kirill Gorshkov and Jin Zhang -- chapter 6. Structural characterization of Epac by x-ray crystallography / Holger Rehmann -- chapter 7. Sensory neuron cAMP signaling in chronic pain / Niels Eijkelkamp, Pooja Singhmar, Cobi J. Heijnen, and Annemieke Kavelaars -- chapter 8. Monitoring real-time cyclic nucleotide dynamics in subcellular microdomains / Zeynep Bastug and Viacheslav O. Nikolaev -- chapter 9. Identifying complexes of adenylyl cyclase with A-Kinase anchoring proteins / Yong Li and Carmen W. Dessauer -- chapter 10. Assessing cyclic nucleotide binding domain allostery and dynamics by NMR spectroscopy / Bryan VanSchouwen, Madoka Akimoto, Stephen Boulton, Kody Moleschi, Rajanish Giri, and Giuseppe Melacini -- chapter 11. A protocol for expression and purification of cyclic nucleotide-free protein in Escherichia coli / Jeong Joo Kim, Gilbert Y. Huang, Robert Rieger, Antonius Koller, Dar-Chone Chow, and Choel Kim -- chapter 12. Cyclic nucleotide analogues as chemical tools for interaction analysis / Robin Lorenz, Claudia Hahnefeld, Stefan Möller, Daniela Bertinetti, and Friedrich W. Herberg -- chapter 13. Dissecting the physiological functions of PKA using genetically modified mice / Brian W. Jones, Jennifer Deem, Linghai Yang, and G. Stanley McKnight
Summary Showcasing the recent progresses of the field, Cyclic Nucleotide Signaling covers the major tools and methodologies used in various areas of research. The majority of the chapters are protocol oriented, with the goal of providing clear directions for laboratory use. Students and investigators new to the field will find this book particularly informative, as will scientists already actively researching nucleotide signaling
Notes Online resource; title from PDF title page (EBSCO, viewed May 15, 2015)
Subject Cyclic nucleotides.
Nucleotides, Cyclic
SCIENCE -- Life Sciences -- Biochemistry.
Cyclic nucleotides
Form Electronic book
Author Cheng, Xiaodong, editor.
ISBN 9781482235579