| Description |
xi, 356 pages : illustrations ; 26 cm |
| Contents |
1. Introduction -- 2. Pairwise alignment -- 3. Markov chains and hidden Markov models -- 4. Pairwise alignment using HMMs -- 5. Profile HMMs for sequence families -- 6. Multiple sequence alignment methods -- 7. Building phylogenetic trees -- 8. Probabilistic approaches to phylogeny -- 9. Transformational grammars -- 10. RNA structure analysis -- 11. Background on probability |
| Summary |
This book provides the first unified, up-to-date, and tutorial-level overview of sequence analysis methods, with particular emphasis on probabilistic modelling. Pairwise alignment, hidden Markov models, multiple alignment, profile searches, RNA secondary structure analysis, and phylogenetic inference are treated at length. Written by an interdisciplinary team of authors, the book is accessible to molecular biologists, computer scientists and mathematicians with no formal knowledge of each others' fields. It presents the state-of-the-art in this important, new and rapidly developing discipline |
| Bibliography |
Includes bibliographical references (pages 326-344) and indexes |
| Subject |
Nucleotide sequence -- Statistical methods.
|
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Amino acid sequence -- Statistical methods.
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Numerical analysis.
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Probabilities.
|
| Author |
Durbin, Richard.
|
| LC no. |
97046769 |
| ISBN |
0521620414 (hardcover) |
|
0521629713 (paperback) |
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