Title Computer analysis of sequence data. Part II / edited by Annette M. Griffin and Hugh G. Griffin

Published Totowa, N.J. : Humana Press, ©1994

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Description 1 online resource (xii, 433 pages) : illustrations Series Methods in molecular biology ; v. 25 Methods in molecular biology (Clifton, N.J.) ; v. 25. 1064-3745 Contents Computer analysis of sequence data -- Staden : introduction -- Staden : sequence input, editing and sequence library use -- Staden : managing sequence projects -- Staden : statistical and structural analysis of nucleotide sequences -- Staden : searching for restriction sites -- Staden : translating and listing nucleic acid sequences -- Staden : searching for motifs in nucleic acid sequences -- Staden : using patterns to analyze nucleic acid sequences -- Staden : analyzing sequences to find genes -- Staden : statistical and structural analysis of protein sequences -- Staden : searching for motifs in protein sequences -- Staden : using patterns to analyze protein sequences -- Staden : comparing sequences -- Staden plus -- DNA strider : a Macintosh program for handling protein and nucleic acid sequences -- MacVector : an integrated sequence analysis program for the Macintosh -- MacVector : aligning sequences -- MacVecto r: sequence comparisons using a matrix method -- MacVector : restriction enzyme analysis -- MacVector : protein analysis -- Profile analysis -- Prediction of RNA secondary structure by energy minimization -- Classification and function prediction of proteins using diagnostic amino acid patterns -- CLUSTAL V : multiple alignment of DNA and protein sequences -- Progressive multiple alignment of protein sequences and the construction of phylogenetic trees -- The AMPS package for multiple protein sequence alignment -- TreeAlign -- Using the FASTA program to search protein and DNA sequence databases -- Converting between sequence formats -- Obtaining software via INTERNET -- Submission of nucleotide sequence data to EMBL/GenBank/DDBJ Summary DNA sequencing has become increasingly efficient over the years, resulting in an enormous increase in the amount of data gener­ ated. In recent years, the focus of sequencing has shifted, from being the endpoint of a project, to being a starting point. This is especially true for such major initiatives as the human genome project, where vast tracts of DNA of unknown function are sequenced. This sheer volume of available data makes advanced computer methods essen­ tial to analysis, and a familiarity with computers and sequence analy­ sis software a vital requirement for the researcher involved with DNA sequencing. Even for nonsequencers, a familiarity with sequence analysis software can be important. For instance, gene sequences already present in the databases can be extremely useful in the design of cloning and genetic manipulation experiments. This two-part work on Computer Analysis of Sequence Data is designed to be a practical aid to the researcher who uses computers for the acquisition, storage, or analysis of nucleic acid (and/or pro­ tein) sequences. Each chapter is written such that a competent scien­ tist with basic computer literacy can carry out the procedure successfully at the first attempt by simply following the detailed prac­ tical instructions that have been described by the author. A Notes section, which is included at the end of each chapter, provides advice on overcoming the common problems and pitfalls sometimes encoun­ tered by users of the sequence analysis software Bibliography Includes bibliographical references and indexes Notes English Print version record Subject Nucleotide sequence -- Data processing Amino acid sequence -- Data processing Amino acid sequence. Sequence Analysis, DNA -- methods Amino Acid Sequence Base Sequence Software software. Amino acid sequence Amino acid sequence -- Data processing Nucleotide sequence -- Data processing Séquence d'acides aminés. Séquence de base nucléotidique. Détermination séquence ADN -- Méthode. Logiciel. Aminozuren. Nucleotiden. Sequentiële analyse (scheikunde) Wetenschappelijke technieken. Séquençage des acides nucléiques. Genre/Form Laboratory manuals. Manuels de laboratoire. Form Electronic book Author Griffin, Annette M. Griffin, Hugh G. ISBN 9781592595129 159259512X 0896032760 9780896032767

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