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Book Cover
E-book

Title Telomerase inhibition : strategies and protocols / edited by Lucy G. Andrews and Trygve O. Tollefsbol
Published Totowa, N.J. : Humana Press, ©2007

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Description 1 online resource (x, 193 pages) : illustrations
Series Methods in molecular biology ; v. 405
Methods in molecular biology (Clifton, N.J.) ; v. 405. 1064-3745
Contents Methods of telomerase inhibition -- Telomerase inhibition by synthetic nucleic acids and chemosensitization in human bladder cancer cell lines -- hTERT knockdown in human embryonic kidney cells using double-stranded RNA -- RNA interference using a plasmid construct expressing a short-hairpin RNA -- Retrovirus-mediated RNA interference -- Telomerase inhibition and telomere targeting in hematopoietic cancer cell lines with small non-nucleosidic synthetic compounds (BIBR1532) -- Uses of telomerase peptides in anti-tumor immune therapy -- Establishing cell-based reporter systems for the analysis of hTERT expression -- Telomerase RNA inhibition using antisense oligonucleotide against human telomerase RNA linked to a 2',5'-oligoadenylate -- Knockdown of telomerase RNA using hammerhead ribozymes and RNA interference -- Evaluation of tankyrase inhibition in whole cells -- Inhibition of telomerase by targeting MAP kinase signaling -- Screening of telomerase inhibitors -- Telomerase inhibition combined with other chemotherapeutic reagents to enhance anti-cancer effect
Summary Due in part to the selective nature of telomerase inhibition as an anticancer approach, the field has expanded considerably in the past decade. The recent advances in methods of telomerase inhibition encompass many different areas of research including molecular biology, cell biology, biochemistry, oncology and gerontology. Telomerase Inhibition provides methods and protocols for those researchers. The techniques described in this book should provide the researcher with a diverse and comprehensive set of tools with which to study telomerase inhibition. Leaders in the field provide recently developed methods that have widespread application such as targeting the telomerase holoenzyme, its RNA template and other elements associated with telomerase activity. Additional methods involving the screening of telomerase inhibitors and telomerase inhibition combined with other chemotherapeutic agents are presented. This text, on the cutting edge of the field, will provide investigators with the most recent methods applied to the expanding field of telomerase inhibition
Analysis telomeren
telomeres
enzymen
enzymes
reverse transcriptase remmers
reverse transcriptase inhibitors
enzymremmers
enzyme inhibitors
remming
inhibition
reverse transcriptase
biologische technieken
biological techniques
protocollen
protocols
Molecular Genetics
Moleculaire genetica
Bibliography Includes bibliographical references and index
Notes English
Print version record
Subject Telomerase -- Inhibitors
Telomerase -- Laboratory manuals
Telomerase.
Oligonucleotides.
Chemotherapy.
Nucleic acids.
Bladder -- Diseases.
Nucleoproteins.
Therapeutics.
Reverse transcriptase.
Nucleotides.
Urinary organs -- Diseases.
Genitourinary organs -- Diseases.
Carrier proteins.
Proteins.
Diseases.
Phosphotransferases.
Transferases.
Enzymes.
Urinary Bladder Neoplasms
Telomerase
Oligonucleotides
Drug Therapy
Polynucleotides
Urologic Neoplasms
Urinary Bladder Diseases
Ribonucleoproteins
Therapeutics
RNA-Directed DNA Polymerase
RNA-Binding Proteins
Urogenital Neoplasms
Nucleotides
Urologic Diseases
Analytical, Diagnostic and Therapeutic Techniques and Equipment
DNA-Directed DNA Polymerase
Nucleic Acids, Nucleotides, and Nucleosides
Female Urogenital Diseases
Male Urogenital Diseases
Carrier Proteins
Nucleoproteins
DNA Nucleotidyltransferases
Neoplasms by Site
Proteins
Chemicals and Drugs
Disease
Nucleotidyltransferases
Female Urogenital Diseases and Pregnancy Complications
Neoplasms
Phosphotransferases
Amino Acids, Peptides, and Proteins
Transferases
Enzymes
Enzymes and Coenzymes
protein.
enzyme.
treating (health care function)
Urinary organs -- Diseases
Transferases
Therapeutics
Reverse transcriptase
Proteins
Phosphotransferases
Oligonucleotides
Nucleotides
Nucleoproteins
Nucleic acids
Genitourinary organs -- Diseases
Enzymes
Diseases
Chemotherapy
Carrier proteins
Bladder -- Diseases
Telomerase
Genre/Form Laboratory manuals
Laboratory manuals.
Manuels de laboratoire.
Form Electronic book
Author Andrews, Lucy G.
Tollefsbol, Trygve O.
ISBN 9781603270700
1603270701
9781597455015
1597455016