| Description |
1 online resource (xiii, 321 pages) : illustrations |
| Contents |
Part PART ONE General Features -- chapter 1 Mechanisms of Action of Antisense Oligonucleotides / D.M. Tidd -- part PART TWO Chemical Aspects -- chapter 2 Chemistry of Oligonucleotides / J.W. Engels -- chapter 3 The Oligonucleoticle Prodrug Approach -- chapter 4 Peptide Nucleic Acids / P.E. Nielsen -- part PART THREE Delivery -- chapter 5 Peptide-mediated Delivery of Oligonucleotides / E. Vivès -- chapter 6 Polymeric Nanoparticles and Microparticles as Carriers for Antisense Oligonucleotides / E. Fattal -- chapter 7 Liposomes for the Delivery of Oligonucleotides / P. Couvreur -- chapter 8 Comb-type Polycation Copolymer for Antigène Strategy and DNA Carrier -- part PART FOUR Biopharmaceutics -- chapter 9 Delivery of Antisense Oligonucleotides in Vitro -- chapter 10 Mechanisms of Transmembrane Transport of Oligonucleotides -- chapter 11 Pharmacokinetics of Oligodeoxynucleotides / A. Gouyette -- part PART FIVE Pharmacological Activity -- chapter 12 Antisense as a Novel Therapy for Cancer / B.P. Monia -- chapter 13 Modulation of Inflammatory Processes with Antisense Oligonucleoticles -- chapter 14 Oligonucleotides as Antiparasite Compounds / J.-J. Toulmé |
| Summary |
Oligonucleotides with base sequences complementary (antisense) to a specific RNA or DNA offer the exciting potential of selectively modulating the expression of an individual gene. Those molecules are gaining interest of the rapid progress in molecular biology and broad scope of potential applications in treating human diseases. However, oligonucleotides diffuse poorly through the biological barriers, including cell membrane. In addition, they are rapidly degraded in vivo by nucleases. Thus, to improve the administration of these compounds is a real challenge that this book will, in part, focus on. Therefore, particular emphasis will be placed on the developments of the chemistry as well as on the formulation and the controlled delivery of these compounds. Background information concerning intracellular trafficking and tissue distribution/pharmacokinetics will also be given. In addition, the therapeutical aspects will also be given consideration. The target audience are researchers working within academia and industry as well as those in management positions in companies that are involved in the field of oligonucleotide therapy.; This book is also vital for postgraduate students who need to be well informed about this currently hot topic |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Print version record |
| Subject |
Oligonucleotides -- Therapeutic use
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Oligonucleotides -- therapeutic use
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Oligonucleotides -- adverse effects
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MEDICAL -- Pharmacology.
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Oligonucleotides -- Therapeutic use
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| Form |
Electronic book
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| Author |
Couvreur, Patrick, 1950-
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Malvy, Claude, 1947-
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| ISBN |
0203305663 |
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9780203305669 |
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1280066873 |
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9781280066870 |
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