| Description |
1 online resource (386 pages, 12 unnumbered pages of plates) : illustrations (some color) |
| Series |
Drug discovery series ; 7 |
|
Drug discovery series ; 7
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| Contents |
DNA Biochips -- Past, Present, and Future: An Overview, G. Hardiman and A.A. Carmen ; Introduction; Evolution and Development of Biochips; Biochips Platforms: Comparisons and Contrasts; References; Three-Dimensional HydroArrays: Novel Microarrays for Genomic and Proteomic Studies, R. Fagnani, P. Tsinberg, and T.J. Pircher ; Introduction; Three-Dimensional HydroArrays; HydroArray Chemistry; Example of Focus Three-Dimensional HydroArrays; In-Vitro Diagnostic Applications; Protein Three-Dimensional HydroArrays; Conclusions; References; Biochip in Malaria for Antiparasitic Discovery, K. Le Roch and E. Winzeler ; Introduction; Malaria; Life Cycle of the Malaria Parasite; Short Oligonucleotide vs |
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Long Oligonucleotide Microarray; Biological Relevance of Expression Profiling; The Use of Biochips for Elucidating the Mechanism of Drug Action; Vaccine Development; Conclusions; References; Regional Variations in Intestinal ATP-Binding Cassette Transporter Expression Identified with a Global Error Assessment Model, D.M. Mutch, A. Petrov, J.B. German, G. Williamson, and M.-A. Roberts ; Introduction; Global Error Assessment (GEA) Model; Regional Variations in ABC Transporter Expression in the Intestine; Validation 1: GEA Analysis of Microarray Data vs. Real-Time PCR; Validation 2: GEA Analysis of Microarray Data vs. an in Silico cDNA Data Set; Validation 3: GEA Analysis of Microarray Data vs. Protein Expression; Conclusion; References; Toxicogenomics in Drug Safety Evaluation: Bridging Drug Discovery and Development, A.Y. Nie, M.K. McMillian, and P.G |
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Lord ; Introduction; Toxicogenomics Experimental Design; Case Study: PPAR Agonist Example; Summary and Conclusions; References; The Next Generation of Automated Microarray Platforms for a Multiplexed CYP2D6 Assay, P. Kim, Y.-K. Ken Fu, V. Mahant, F. Kureshy, G. Hardiman, and J. Corbeil ; Introduction; The INFINITI™ Platform; CYP2D6 Genotyping; Results and Discussion; Conclusion; Acknowledgments; References; Biopsy and RNA Extraction Procedures of Muscle and Adipose Tissue for Microarray Gene-Expression Profiling, M.B.A. van Doorn, M.J.B. Kemme, M. Ouwens, E.J. van Hoogdalem, X. Liu, Q.S. Li, C.R. Jones, M.L. de Kam, J. Burggraaf, and A.F |
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Cohen ; Introduction; Subjects and Methods; Blood Sampling and Leukocyte Isolation; RNA Extraction; Microarray Data Analysis; Results; Evaluation of Gene Expression Profiles in Biopsy Tissues and White Blood Cells; Discussion; References; ChIP-on-Chip: Analysis of Genomewide Protein Binding and Posttranslational Modifications, D. Robyr ; Abstract; Introduction; ChIP-on-Chip: Brief History and Overview of the Method; Yeast ChIP-on-Chip and Beyond; ChIP-on-Chip and Biomedical Applications; Concluding Remarks; Acknowledgments; References; DNA Microarrays as Functional Genomics Tools for Cancer Drug Discovery, A |
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Bhattacharjee ; Abstract; Introduction: DNA Microarrays in Drug Discovery; From Cancer Classification to Drug Discovery; Hunting and Screening Approaches in Drug Discovery; The Era of DNA Microarrays; Impact of Mechanism-Based Studies in Cancer Drug Discovery and Development; Future of Microarrays in System-Level Overview of Cancer and Therapeutic Intervention; Conclusions; Acknowledgments; Additional Notes; References High-Throughput Microarray Analysis, S. Sheth ; Developing the HT Array; Applications to Drug Discovery and Development; More Successful Clinical Trials; The Way Ahead; References; Laboratory Automation: Strategies for High-Volume Industrial Microarray Programs, A. Bittner and A.A |
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Carmen ; Abstract; Introduction; Benefit of Automation to Microarray Experiments; Automation for Array Processing; Data Collection, Analysis, and Sample Tracking; Pitfalls of Automation; Summary; References; Association Studies: Practical and Theoretical Considerations for Drug Discovery, Evaluation, and Beyond, R.M. Kliman, F. Barany, N. Cohen, and R. Favis ; Introduction; Technical Considerations; Biological Considerations; Concluding Remarks; References Approaches for Microarray Data Validation, S.E. Ilyin ; Acknowledgments; References; Microarray Enterprise Information Management: What Is It and Why Is It Important? P . Morrison, P. Prakash, and S |
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Shams ; Abstract; Introduction; Importance of Systematic Data Management for Quality Assurance; Data Management Needs at Each Step of Array Experiment; Conclusions; References; Quality Control of Microarray Data, H. Xiao, A. Leung, and L. Yieh ; Introduction; Algorithms Developed for Microarray Quality Control; Automation of Quality Control; Automatic Monitoring of Expression Data Improves Throughput of Data Processing and Data Quality; Conclusions; References; Microarray Data Normalization and Transformation, H. Xiao, L. Yieh, and H. Dai ; Overview; Linear Normalization; Intensity-Dependent Normalization; Choosing a Normalization Method; Normalization for Oligonucleotide-Based Arrays; Performance of Normalization; Data Transformation; Conclusion; References; Amplification Strategies and DNA Biochips, B. Ruggeri, L. Soverchia, M |
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Ubaldi, R. Ciccocioppo, and G. Hardiman ; Introduction; Laser Capture Microdissection (LCM); Microarray Target Labeling; Conclusion; References; Ribo-SPIA™, a Rapid Isothermal RNA Amplification Method for Gene Expression Analysis, A. Dafforn, P. Chen, G.Y. Deng, M. Herrler, D.M. Iglehart, S. Koritala, S.M. Lato, S. Pillarisetty, R. Purohit, L. Turner, M. Wang, S. Wang, and N |
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Kurn ; Introduction; Ribo-SPIA™: A Novel Method for Global Isothermal Linear Amplification of mRNA; Ribo-SPIA™ Protocol for Rapid Robust Amplification of Total mRNA in Small Total RNA Samples; Accuracy, Reproducibility, and Linearity of Ribo-SPIA™ Assessed by qPCR; Expression Analysis Using the Ribo-SPIA™ Amplification and GeneChip® Arrays; Performance of Ribo-SPIA™-Amplified Product on Two-Color Spotted Arrays; Conclusions; Materials and Methods; Acknowledgments; References; Genomics, Transcriptomics, and Proteomics: Novel Detection Technologies and Drug Discovery, P |
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Stafford ; Background and Introduction; Fostering Biological Knowledge: Cross-Discipline Data; Unifying the Biological (Data) World; The Legacy of Expression Arrays; Systems Biology -- Driving Drug Development through Data Integration; Controls and Standards; Biomarkers and the History of Genetics; SNP Detection; Some Detection Technologies of Interest; NonSNP Technology: The Protein Chip, Microfluidics, |
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And Assorted Engineering Marvels; Microfluidics and Alternate Small-Scale Detection Devices; Other Biomolecule Detection Methods; SNP Detection: Major Commercial Technologies; SNP Detection Diversity; SNP Detection: Electronic Detection; SNP Detection: Bead-Based; The SNP Chip: Flow-Through Methods; SNP Detection: Sequence-Based; SNP Detection: Alternate Detection Methods; SNP Technology: Analysis Software; Discussion; References; Intellectual Property Issues for DNA Chips and Microarrays, V.G. Norton ; Overview of Patent Law Statutes and Guidelines Applied to Genomic Inventions; IP Implications for DNA Chips and Microarrays; Other Solutions to Promote Innovation: Free Sharing of SNP Information; Conclusion; Biochips: Market Drivers and Commerci |
| Summary |
In the fiercely competitive pharmaceutical marketplace, your organization cannot afford to spend excess dollars developing drugs that will fail to get FDA approval or have profoundly poor characteristics. Biochips as Pathways to Drug Discovery takes a comprehensive look at how the industry faces these challenges, using new technologies such as biochips to reduce the cost of drug discovery and improve drug safety. The book explores the tools and skills required at each step of the discovery process when using biochips to determine biological outcomes. The authors provide an in-depth |
| Bibliography |
Includes bibliographical references and index |
| Notes |
English |
|
Print version record |
| Subject |
Biochips.
|
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Drug development.
|
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Drugs -- Design.
|
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Oligonucleotide Array Sequence Analysis
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Drug Design
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MEDICAL -- Drug Guides.
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MEDICAL -- Pharmacology.
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MEDICAL -- Pharmacy.
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MEDICAL -- Nursing -- Pharmacology.
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Drugs -- Design
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Biochips
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Drug development
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| Form |
Electronic book
|
| Author |
Carmen, Andrew
|
|
Hardiman, Gary, 1966-
|
| ISBN |
9781420015607 |
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1420015605 |
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9780429117633 |
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0429117639 |
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1280733586 |
|
9781280733581 |
|
9786610733583 |
|
6610733589 |
|
