Title Protocols for oligonucleotides and analogs : synthesis and properties / edited by Sudhir Agrawal

Published Totowa, N.J. : Humana Press, ©1993

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Description 1 online resource (xiv, 502 pages) : illustrations Series Methods in molecular biology ; v. 20 Methods in molecular biology (Clifton, N.J.) ; v. 20 Contents A brief history of oligonucleotide synthesis / Daniel M. Brown -- Oligonucleotide synthesis : phosphotriester approach / Chris Christodoulou -- Oligodeoxyribonucleotides synthesis : phosphoramidite approach / Serge L. Beaucage -- Oligodeoxynucleotide synthesis : H-phosphonate approach / Brian C. Froehler -- Oligoribonucleotide synthesis : the silyl-phosphoramidite method / Masad J. Damha, Kelvin K Ogilvie -- Synthesis of 2'-O-alkyloligoribonucleotides / Brian S. Sproat -- An improved method for the synthesis and deprotection of methylphosphonate oligonucleotides / Richard I. Hogrefe, Mark A. Reynolds, Morteza M. Vaghefi, Kevin M. Young, Timothy A. Riley, Robert E. Klem, Lyle J. Arnold -- Oligonucleoside phosphorothioates / Gerald Zon -- Synthesis and purification of phosphorodithioate DNA / W.T. Wiesler, W.S. Marshall, M.H. Caruthers -- Oligodeoxyribonucleotide phosphotriesters / Maria Koziolkiewicz, Andrzej Wilk -- Oligonucleoside boranophosphate (borane phosphonate) / Barbara Ramsay Shaw, Jon Madison, Anup Sood, Bernard F. Spielvogel -- Oligonucleotide phosphorofluoridates and fluoridites / Wojciech Dabkowski, Jan Michahki, Friedrich Cramer -- [Alpha]-oligodeoxynucleotides / François Morvan, Bernard Rayner, Jean-Louis Imbach -- Stereospecific synthesis of P-chiral analogs of oligonucleotides / Wojciech J. Stec, Zbigniew J. Lesnikowski -- Oligonucleotide analogs with dimethylenesulfide, -sulfoxide, and -sulfone groups replacing phosphodiester linkages / Zhen Huang, K. Christian Schneider, Steven A. Benner -- Oligonucleotide analogs containing dephospho-internucleoside linkages / Eugen Uhlmann, Anusch Peyman -- Scale-up of oligonucleotide synthesis : solution phase / H. Seliger -- Large-scale oligonucleotide synthesis using the solid-phase approach / Nanda D. Sinha -- Solid-phase supports for oligonucleotide synthesis / Richard T. Pon Summary Leading researchers summarize and describe their experience and techniques for synthesizing oligonucleotides and their analogs. The protocols presented cover all DNA analogs that have been studied to date and constitute the single most extensive source of knowledge about DNA chemistry available Analysis oligonucleotiden oligonucleotides synthese synthesis fysicochemische eigenschappen physicochemical properties Nucleic Acids Bibliography Includes bibliographical references and index Notes Master and use copy. Digital master created according to Benchmark for Faithful Digital Reproductions of Monographs and Serials, Version 1. Digital Library Federation, December 2002. http://purl.oclc.org/DLF/benchrepro0212 MiAaHDL English Print version record digitized 2010 HathiTrust Digital Library committed to preserve pda MiAaHDL In Springer Protocols Subject Oligonucleotides -- Synthesis Oligonucleotides -- Derivatives -- Synthesis Oligonucleotides -- chemical synthesis Oligonucleotides -- chemistry Oligonucleotides -- Synthesis Oligonucleotiden. Synthese (chemie) Wetenschappelijke technieken. Genre/Form Laboratory manuals. Manuels de laboratoire. Form Electronic book Author Agrawal, Sudhir. ISBN 9781592595075 1592595073

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