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Title Metal-carbon bonds in enzymes and cofactors / edited by Astrid Sigel, Helmut Sigel, and Roland K.O. Siegel
Published Cambridge, UK : RSC Publishing, ©2009

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Description 1 online resource (xxvii, 510 pages) : illustrations (some color)
Series Metal ions in life sciences ; v. 6
Metal ions in life sciences ; v. 6.
Contents Organometallic chemistry of B₁₂ coenzymes -- Cobalamin- and corrinoid-dependent enzymes -- Nickel-alkyl bond formation in the active site of methyl-coenzyme M reductase -- Nickel-carbon bonds in acetyl-coenzyme a synthases/carbon monoxide dehydrogenases -- Structure and function of [NiFe]-hydro-genases -- Carbon monoxide and cyanide ligands in the active site of [FeFe]-hydrogenases -- Carbon monoxide as intrinsic ligand to iron in the active site of [Fe]-hydrogenase -- Dual role of heme as cofactor and substrate in the biosynthesis of carbon monoxide -- Copper-carbon bonds in mechanistic and structural probing of proteins as well as in situations where copper is a catalytic or receptor site -- Interaction of cyanide with enzymes containing vanadium, manganese, non-heme iron, and zinc -- Reaction mechanism of the molybdenum hydroxylase xanthine oxidoreductase: evidence against the formation of intermediates having metal-carbon bonds
Summary The occurrence of a wide variety of metal-carbon bonds in living organisms, ranging from bacteria to humans, is only recently recognized. Of course, the historical examples are the B12 coenzymes containing cobalt-carbon bonds, but now such bonds are also known for nickel, iron, copper, and other transition metal ions. There is no other comparable book; MILS-6, written by 17 experts, summarizes the most recent insights into this fascinating topic
Bibliography Includes bibliographical references and indexes
Notes English
Subject Metalloenzymes.
Coenzymes.
Organometallic compounds
Vitamin B12.
Coenzymes -- chemistry [mesh]
Organometallic Compounds -- chemistry [mesh]
Coenzymes -- chemistry
Organometallic Compounds -- chemistry
Coenzymes
Organometallic Compounds
Vitamin B 12
Multienzyme Complexes -- chemistry [mesh]
Oxidoreductases -- chemistry [mesh]
Vitamin B 12 -- chemistry [mesh]
Multienzyme Complexes -- chemistry
Oxidoreductases -- chemistry
Vitamin B 12 -- chemistry
organometallic compound.
Coenzymes
Metalloenzymes
Organometallic compounds
Vitamin B12
Cofaktor
Enzym
Metallorganische Verbindungen
Form Electronic book
Author Sigel, Astrid
Sigel, Helmut
Sigel, Roland K. O
ISBN 9781847559333
1847559336
9781847559159
1847559158
9783110442793
3110442795
9783110436587
3110436582