| Description |
1 online resource |
| Contents |
Intro -- Novel Therapeutic Approaches Targeting Oxidative Stress -- Copyright -- Dedication -- Contents -- Contributors -- Preface -- Acknowledgments -- Chapter 1: Novel therapeutic approaches targeting oxidative stress in mood disorders -- 1 Introduction -- 2 The production of ROS in the brain -- 3 The elimination of ROS in the brain -- 4 Oxidative stress in the brain -- 5 Markers of oxidative stress and mood disorders -- 6 Antioxidant treatments in mood disorders -- 6.1 Antioxidant action of conventional treatments for mood disorders -- 6.2 Antioxidants as an add-on therapy in mood disorders -- 6.2.1 N -acetylcysteine (NAC) -- 6.2.2 Medications with some antioxidant action but not as the main mechanism of action -- 6.3 Manipulation of oxidative stress through lifestyle interventions -- 7 Conclusions -- References -- Chapter 2: Ferroptosis: Oxidative stress and pathophysiology -- 1 Introduction -- 2 Immunology -- 3 Conclusion -- Acknowledgment -- Conflict of interest -- References -- Chapter 3: Oxidative stress and its biological significance -- 1 Introduction -- 2 Oxidative stress in 4-hydroxynonenal (HNE) leading to apoptosis -- 3 Antioxidant supplementation increasing tumorigenesis -- 3.1 Generation of mitochondrial ROS and cancer formation -- 4 Regulation of the cell cycle in the oxidative state -- 5 Viral infections and oxidative stress -- 6 Epigenetic factors and carcinogenesis -- 7 Extracellular superoxide angles and apoptosis -- 7.1 HNE and its adducts in the regulation of transcription factors -- 7.2 How oxidative DNA damage is critical to cancer -- 7.3 Transcription factors that promote cancer -- 7.4 Tumor-promoting genetic changes induce endogenous antioxidants -- 7.5 Endogenous antioxidants promote cell migration and metastasis -- 7.6 N -acetylcysteine-More than an antioxidant |
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Chapter 4: Novel therapeutic approaches targeting oxidative stress in aging -- 1 Introduction -- 2 Hallmarks of aging -- 3 Causes of aging -- 4 Age-associated diseases -- 4.1 Alzheimer's disease -- 4.2 Cardiovascular disease -- 4.3 Diabetes -- 4.4 Cancer -- 5 Novel therapeutic approaches -- 5.1 Role of quercetin -- 5.2 Role of curcumin -- 5.3 Role of resveratrol -- 6 Liposomes -- 6.1 Charge on liposomes -- 6.2 Role of liposomes in various diseases -- 7 Conclusion -- Acknowledgments -- References -- Chapter 5: Novel therapeutic approaches targeting oxidative stress in neurodegenerative diseases -- 1 Introduction -- 2 Dimensions of aging in the investigation of neurodegeneration -- 2.1 Structural changes in Alzheimer's and Parkinson's disease -- 2.2 Amyloid deposition -- 2.3 Oxidative stress -- 2.4 Immunosenescence -- 2.5 Telomere shortening -- 3 Clinical implications -- 3.1 Antioxidants and antiaging agents' development as drugs -- 3.2 Other pharmacological interventions -- 3.3 Nonpharmacological interventions -- 4 Implications for research -- Acknowledgment -- Conflicts of interest/competing interests -- References -- Chapter 6: The role of oxidative stress in kidney diseases -- 1 Introduction -- 2 Kidney architecture at the cellular level -- 3 Nephrotoxicity and renal pathology -- 3.1 Source of nephrotoxicity -- 3.1.1 Therapeutic agents -- 3.1.2 Environmental pollutants/toxins -- 3.1.3 Diagnostic agents -- 3.1.4 Alternative/health products -- 4 Classification of kidney diseases -- 4.1 Acute renal injury (ARI) -- 4.2 Chronic kidney disease (CKD) -- 5 The chemical species of oxidative stress -- 5.1 Cellular mechanism for the formation of reactive oxygen species -- 6 Cellular antioxidant defense system -- 6.1 Superoxide dismutase (SOD) -- 6.2 Glutathione peroxidase (GSHPX) -- 7 Sources of ROS in the kidneys |
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7.1 NADPH oxidase as a source of ROS -- 7.2 Mitochondrial ROS -- 8 Reactive oxygen species and kidney diseases -- 9 Oxidative stress in the renal tubules -- 9.1 Proximal tubule -- 9.2 Medulla -- 9.3 Distal and collecting duct -- 10 Oxidative stress in the glomerulus -- 11 Oxidative stress in the renal vasculature -- 12 Role of ROS in ischemia and reperfusion (I/R)-induced acute kidney injury -- References -- Chapter 7: The role of oxidative stress and antioxidants across the spectrum of acute coronary syndrome -- 1 Introduction -- 2 Oxidative stress -- 3 Endothelial dysfunction and oxidative stress -- 4 Molecular effects of oxidative stress -- 5 Oxidative stress in coronary artery disease -- 6 Coronary microvascular dysfunction -- 7 Oxidative stress and lipids, protein, and DNA damage -- 8 Therapies for oxidative stress-associated cardiovascular diseases -- 8.1 Antioxidant molecules -- 8.1.1 Nutritional supplements -- 8.1.2 Novel experimental antioxidant-based therapies -- 8.1.3 Antioxidant role of clinical drugs -- 8.2 miRNAs -- 8.3 Limitations -- 9 Conclusions -- References -- Chapter 8: Biosensors in the detection of oxidative stress using discovered biomarkers -- 1 Introduction -- 2 Biosensors -- 2.1 Working principle -- 2.2 Types of biosensors -- 2.2.1 Electrochemical biosensors -- 2.2.2 Optical biosensors -- 2.3 Other biosensors -- 2.3.1 Piezoelectric biosensors -- 2.3.2 Calorimetric biosensors -- 2.3.3 Immuno-biosensors -- 2.3.4 Nano biosensors -- 2.3.5 Fluorescent biosensors -- 2.3.6 Whole cell biosensors -- 3 Biomarkers -- 3.1 Genomic biomarkers -- 3.2 Transcriptomic biomarkers -- 3.3 Proteomic biomarkers -- 3.4 Metabolomic biomarkers -- 4 Overview of discovered biomarkers for oxidative stress -- 5 Management of oxidative stress conditions -- 5.1 Habits and lifestyle -- 5.2 Food and beverage intake |
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5.3 Supplements and antioxidants -- 5.4 Yoga, exercise, and meditation -- 5.5 Healthcare situations and its management -- 6 Research trends and future challenges in development of biosensors -- 7 Conclusion -- Acknowledgments -- References -- Chapter 9: Biochemical approaches/methods in the detection of free radicals -- 1 Introduction -- 2 In vitro methods -- 3 Chemiluminescence-derived methods using luciferine derivatives -- 4 Reduction of cytochrome c -- 5 NBT tests -- 6 Aconitase inactivation -- 7 Boronates -- 8 In vivo methods -- 9 Redox potential of the GSH/GSSG couple -- 10 Measurement of F2-isoprostanes as indicators of lipid per-oxidation -- 11 Reporter assays -- 12 Fluorescent protein-based methods -- 13 Analytical methods -- 14 Fluorescence-dependent methods -- 15 Electron spin resonance (ESR) or electron paramagnetic resonance (EPR) spectroscopy -- 16 Spin trapping technique -- 17 Immuno-spin trapping of macromolecules -- 18 Combined IST and mMRI detection -- 19 Pulse radiolysis -- 20 Chromatography-based techniques -- 21 Other biochemical methods -- 22 Summary -- References -- Chapter 10: Novel therapeutic approaches targeting oxidative stress in breast and lung cancer -- 1 Introduction -- 2 Epidemiology and risk factors -- 2.1 Breast cancer epidemiology -- 2.2 Lung cancer epidemiology -- 3 Role of oxidative stress in cancer pathophysiology -- 3.1 Tumor cellular proliferation and oxidative stress -- 3.2 Metastasis and oxidative stress -- 3.3 Oncogenes, tumor suppressor genes, and oxidative stress -- 3.3.1 MicroRNAs regulated by ROS in cancer -- 4 Classification of breast and lung cancer -- 4.1 Breast cancer -- 4.1.1 Noninvasive breast cancer (NIBC) -- 4.1.2 Invasive breast cancer (IBC) -- 4.1.3 Inflammatory breast cancer -- 4.1.4 Paget's disease of the breast -- 4.1.5 Phyllodes tumor |
| Subject |
Oxidative stress -- Treatment
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Oxidative stress -- Diagnosis
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| Form |
Electronic book
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| Author |
Maurya, Pawan Kumar
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Qamar, Imteyaz
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| ISBN |
9780323909068 |
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032390906X |
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