| Description |
1 online resource (x, 182 pages) : illustrations (some color) |
| Summary |
Over the past several years, there has been an extraordinarily rapid growth in our knowledge of oxidative stress and its possible involvement in both normal essential biology and digestive diseases. Oxidative stress is defined as a disturbance in the prooxidant-antioxidant balance in favor of the former, and has been suggested as a causative factor in inflammation, ischemia and carcinogenesis in the digestive organs. In the 1980s, biochemists and biologists were attracted by the role of reactive oxygen species in the irreversible damage or modification of the structure of biological molecules. However, in the 1990s, reactive oxygen species have been recognized to be involved in reversible structural alterations of molecules: The homeostatic modulation of oxidant levels is a highly efficient mechanism that allows all cells to tightly control their redox status within a very narrow range. Especially the activity of the Rel/NF-kB family of transcriptional factors that regulate responses in inflammation, reperfusion injury and apoptosis is controlled by intracellular reactive oxygen species levels. Our understanding of how these transcriptional factors are negatively or positively regulated by oxidative stress has since greatly increased. Questions for future investigation center on the modulation of oxidative stress by personal genome information for the prevention of several pathologic states |
| Bibliography |
Includes bibliographical references and indexes |
| Notes |
Master and use copy. Digital master created according to Benchmark for Faithful Digital Reproductions of Monographs and Serials, Version 1. Digital Library Federation, December 2002. http://purl.oclc.org/DLF/benchrepro0212 MiAaHDL |
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Print version record |
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digitized 2010 HathiTrust Digital Library committed to preserve pda MiAaHDL |
| Subject |
Digestive organs -- Pathophysiology
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Oxidative stress -- Pathophysiology
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Digestive System Diseases -- physiopathology
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Oxidative Stress -- physiology
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Reactive Oxygen Species -- adverse effects
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Oxidative stress -- Pathophysiology
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Gastrointestinale Krankheit
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Oxidativer Stress
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Kongress
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Verdauungskanal
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Krankheit
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Stickstoffmonoxid
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| Form |
Electronic book
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| Author |
Yoshikawa, Toshikazu
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S. Karger (Firm)
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| ISBN |
9783318007060 |
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3318007064 |
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