| Description |
1 online resource |
| Contents |
Vol. 1. Section 1. Historical perspectives. ch. 1. Metabolic rate, free radicals and aging / R.G. Allen and Arthur K. Balin -- Section 2. Free radical chemistry and biology. ch. 2. Spin-trapping methods for detecting superoxide and hydroxyl free radicals in vitro and in vivo / Garry R. Buettner and Ronald P. Mason -- ch. 3. Peroxyl and alkoxyl radical mediated DNA damage / John Termini -- ch. 4. Nitric oxide, peroxynitrite and ageing / Joseph S. Beckman -- Section 3. Redox regulation and cell signaling. ch. 5. Thioredoxin-dependent redox regulation -- implication in aging and neurological diseases / Itaro Hattori ... [et al.] -- ch. 6. Redox regulation of genes and cell function / Arne Holmgren -- ch. 7. Oxidative stress and signal transduction pathway of redox sensor proteins: clinical applications and novel therapeutics / Toshifumi Tetsuka and Takashi Okamoto -- Section 4. Measurement of oxidative stress: technology, biomarkers and applications. Nucleic acid damage. ch. 8. Measuring oxidative stress and interpreting its clinical relevance for humans / Roy G. Cutler and Mark P. Mattson -- ch. 9. Oxidative damage to DNA: mechanisms of product formation and measurement by mass spectrometric techniques / Miral Dizdaroglu, Pawel Jaruga and Henry Rodriguez -- ch. 10. HPLC-MS/MS measurement of oxidative base damage to isolated and cellular DNA / T. Douki ... [et al.] -- ch. 11. The use of HPLC/EC for measurements of oxidative DNA damage / Mikhail B. Bogdanov, Wayne R. Matson and Ian N. Acworth -- ch. 12. Analysis of 8-hydroxyguanine in DNA and its repair / Takeshi Hirano and Hiroshi Kasai -- ch. 13. HPLC-ECD, HPLC-MS/MS (urinary biomarkers) / H.E. Poulsen ... [et al.] -- ch. 14. Mapping oxidative damage to DNA at nucleotide resolution in mammalian cells / Timothy R. O'Connor ... [et al.] -- ch. 15. Immunochemical detection of oxidative DNA damage / Marcus S. Cooke and Joseph Lunec -- ch. 16. Postlabelling detection of oxidative DNA damage / Michael N. Routledge and George D.D. Jones -- ch. 17. The comet assay: protective effects of dietary antioxidants against oxidative DNA damage measured using alkaline single cell gel electrophoresis / Susan J. Duthie -- Protein damage. ch. 18. Protein oxidation assays / Guohua Cao -- ch. 19. Effect of oxidative stress on protein synthesis / Antonio Ayala and Alberto Machado -- ch. 20. Biological implications of protein oxidation / Sataro Goto, Zsolt Radák and Ryoya Takahashi -- ch. 21. Application of protein chip array technology for the detection of biomarkers of oxidative stress / Charlotte H. Clarke, Scot R. Weinberger and Mark S.F. Clarke -- Lipid damage. ch. 22. Quantification of isoprostanes as an index of oxidant stress status In vivo / Jason D. Morrow ... [et al.] -- ch. 23. Analysis of phospholipid oxidation by electrospray mass spectrometry / Corinne M. Spickett -- Carbohydrate damage. ch. 24. Glycoxidative and carbonyl stress in aging and age-related diseases / Vincent M. Monnier ... [et al.] |
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Mitochondrial damage. ch. 25. Mitochondrial mutations in vertebrate aging / Aubrey D.N.J. de Grey -- ch. 26. Mitochondria, oxidative stress and mitochondrial diseases / Keshav K. Singh, Britt Luccy and Steven J. Zullo -- Standards for oxidative stress measurements. ch. 27. Oxidative DNA damage biomarkers: a need for quality controls / Andrew R. Collins -- Section 5. Dietary antioxidants. ch. 28. Dietary antioxidants -- human studies overview / Paul Milbury and Jeffrey B. Blumberg -- ch. 29. Current status of the potential role of flavonoids in neuroprotection / Hagen Schroeter, Jeremy P.E. Spencer and Catherine Rice-Evans -- ch. 30. Neurological aging and nutritional intervention / Barbara Shukitt-Hale, Kuresh A. Youdim and James A. Joseph -- ch. 31. Comparative study on antioxidant activity against lipid peroxidation / Etsuo Niki and Noriko Noguchi -- ch. 32. [symbol]-tocopherol: beyond the antioxidant dogma / Theresa Visarius and Angelo Azzi -- ch. 33. [symbol]-tocopherol, the neglected form of vitamin E: new functions, new interest / Qing Jiang ... [et al.] -- ch. 34. Ascorbic acid DNA damage and repair / Joseph Lunec -- ch. 35. Carotenoids and oxidative stress / Norman I. Krinsky -- ch. 36. Functional foods / Toshihiko Osawa -- ch. 37. Nutrition and phase II reactions -- the role of glutathione / Tammy M. Bray and Jun Li -- ch. 38. Oligomeric proanthocyanidins in human health and disease prevention / Debasis Bagchi and Harry G. Preuss -- ch. 39. Effects of antioxidant vitamins C and E on gene expression in the vasculature / Helen R. Griffiths and S.J. Rayment -- Section 6. Endogenous antioxidants and repair. ch. 40. Oxidative defense mechanisms / Cheryl Y. Teoh and Kelvin J.A. Davies -- ch. 41. Heme oxygenase: its regulation and role / Herbert L. Bonkovsky and Kimberly K. Elbirt -- ch. 42. Metallothioneins / Y. James Kang -- ch. 43. Human genomic DNA repair enzymes / Timothy R. O'Connor -- ch. 44. DNA repair in mammalian mitochondria / Nadja C. Souza-Pinto and Vilhelm Bohr -- ch. 45. [symbol]-lipoic acid / Chandan K. Sen, Savita Khanna and Sashwati Roy -- ch. 46. Coenzyme Q10 prevents DNA oxidation and enhances recovery from oxidative damage / Renata Alleva -- ch. 47. In vivo assessment of antioxidant status / Mohsen Meydani and Ligia Zubik -- Vol. 2. Section 7. Epidemiology and intervention studies. ch. 48. Epidemiology of antioxidants in cancer and cardiovascular disease / L. Stephen Coles -- ch. 49. Oxidative stress and antioxidant intervention / Freya Q. Schafer, Eric E. Kelley and Garry R. Buettner -- ch. 50. Oxidative stress in human populations / Gladys Block ... [et al.] |
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Section 8. Oxidative stress related diseases. ch. 51. Oxidative stress related diseases -- overview / Joe M. McCord -- ch. 52. Role of oxidative stress and other novel risk factors in cardiovascular disease / Peter Reaven -- ch 53. Overview of oxidative stress and cancer / Steven A. Akman -- ch. 54. Oxidative stress and skin cancer / Arthur K. Balin and R.G. Allen -- ch. 55. Modification of endogenous antioxidant enzymes in the brain as well as extra-brain tissues by propargylamines: is it related to the lifeprolonging effect of (-)deprenyl? / Kenichi Kitani ... [et al.] -- ch. 56. Oxidative stress and age-related macular degeneration / Jiyang Cai, Paul Sternberg, Jr. and Dean P. Jones -- ch. 57. Preeclampsia and antioxidants / Rhoda Wilson -- ch. 58. Iron regulation, hemochromatosis and cancer / Shinya Toyokuni ... [et al.] -- Section 9. Aging and oxidative stress. ch. 59. Aging and oxidative stress in transgenic mice / Holly Van Remmen ... [et al.] -- ch. 60. Caloric restriction, aging and oxidative stress / Kevin C. Kregel -- ch. 61. Hormones and oxidative stress / Holly M. Brown-Borg and S. Mitchell Harmon -- ch. 62. Exercise / Helaine M. Alessio -- Section 10. Evolutionary comparative biology of aging and longevity. ch. 63. Evolutionary basis of human aging / Thomas B.L. Kirkwood -- ch. 64. Genetic stability, dysdifferentiation, and longevity determinant genes / Richard G. Cutler -- ch. 65. The genetics of yeast aging: pathways and processes / S. Michal Jazwinski -- ch. 66. Oxidative stress and longevity determinant genes of drosophila / Robert Arking -- Section 11. Longevity determinant genes and oxidative stress. ch. 67. Toward a unified theory of aging -- what mammals can learn from worms and other ephemeral creatures / Robert J. Shmookler Reis -- ch. 68. Mouse models and longevity / Marco Giorgio and Pier Giuseppe Pelicci -- ch. 69. Oxidative stress, DNA repair and centenarian survival / Richard Marcotte and Eugenia Wang |
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Section 12. Non-invasive assessment of oxidative stress and therapeutic intervention. ch. 70. Strategies for controlling oxidative stress: protection against peroxynitrite and hydroperoxides by selenoproteins and selenoorganic compounds / Helmut Sies and Gavin E. Arteel -- ch. 71. Salen manganese complexes, combined superoxide dismutase/catalase mimetics, demonstrate potential for treating neurodegenerative and other age-associated diseases / Susan R. Doctrow ... [et al.] -- ch. 72. Glutathione peroxidase mimics / Timothy C. Rodell -- ch. 73. Nutritional approaches to reducing oxidative stress / Bryant Villeponteau -- ch. 74. UV-DNA repair enzymes in liposomes / Daniel Yarosh -- ch. 75. Mitochondrial dysfunction in aging and disease: development of therapeutic strategies / James A. Dykens ... [et al.] -- ch. 76. Nitric oxide-blocking therapeutics / Ching-San (Monte) Lai and Norman K. Orida -- ch. 77. Nitric oxide and mammalian aging: "surplus" and "deficit" as the two faces of a pharmaceutical currency for nitric oxide-modulator drugs / David R. Janero -- ch. 78. Genechips for age/stress-related gene expression and analysis / Chris Seidel and Ralph M. Sinibaldi -- Section 13. Future trends in health care. ch. 79. Preventive medicine and health care reimbursement: a necessary but not sufficient condition for wider access to preventive health services / Tali Arik -- ch. 80. Tissue engineering / Hidetomi Terai, Alexander Sevy and Joseph P. Vacanti -- ch. 81. Database analysis of human intervention studies (The Kronos Longitudinal Study of Aging and Anti-aging Interventions) / Christopher B. Heward -- ch. 82. Funding trends and possibilities in oxidative stress and aging research / Huber R. Warner and Bradley Wise -- Section 14. Human life extension. ch. 83. The ethics of longevity: should we extend the healthy maximum lifespan? / Michael Fossel -- ch. 84. Advisability of human life span extension: economic considerations / Henry Rodriguez and Dwayne A. Banks |
| Summary |
This two-volume reference examines the translational research field of oxidative stress and ageing. It focuses on understanding the molecular basis of oxidative stress and its associated age-related diseases, with the goal of developing new methods for treating the human ageing processes |
| Bibliography |
Includes bibliographical references and index |
| Subject |
Aging -- Molecular aspects.
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Oxidation, Physiological.
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Stress (Physiology)
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Oxidative Stress -- physiology
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Aging -- physiology
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Antioxidants -- therapeutic use
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Cellular Senescence -- physiology
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Free Radicals -- adverse effects
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Life Expectancy -- trends
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Review Literature as Topic
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FAMILY & RELATIONSHIPS -- Aging.
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MEDICAL -- Nursing -- Gerontology.
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Aging -- Molecular aspects
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Oxidation, Physiological
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Stress (Physiology)
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| Form |
Electronic book
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| Author |
Cutler, Richard G
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Rodriguez, Henry, 1963-
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| ISBN |
9789812775733 |
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9812775730 |
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