| Description |
1 online resource (xi, 317 pages) : illustrations (some color) |
| Series |
Methods in molecular medicine ; 62 |
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Methods in molecular medicine ; 62. 1543-1894
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| Contents |
880-01 Point mutations in the [Alpha]- synuclein gene / A. Parsian and J.S. Perlmutter -- Autosomal recessive juvenile Parkinsonism (AR-JP): Genetic diagnosis / H. Matsumine, N. Hattori and Y. Mizuno -- Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy as [Alpha]-synucleinopathies / M. Goedert [and others] -- [Alpha]-synuclein/amyloid interactions / P. Henning Jensen -- Functional defect conferred by the Parkinson's disease-causing [Alpha]-synuclein (ala30Pro) mutation / P. Henning Jensen -- Molecular biology of dopamine-induced apoptosis / I. Ziv [and others] -- Animal models of induced apoptotic death in the substantia nigra / T.F. Oo and R.E. Burke -- Apoptotic morphology in phenotypically defined dopaminergic neurons of the substantia nigra / T.F. Oo and R.E. Burke -- The role of nitric oxide in Parkinson's disease / S. Przedborski and T.M. Dawson -- Oxidative stress indices in Parkinson's disease / M.B.H. Youdim, N. Drigues and S. Mandel -- Quantification of tyrosine hydroxylase mRNA / H. Ichinose [and others] -- Immunochemical analysis of dopaminetransporters in Parkinson's disease / G.W. Miller and A.I. Levey -- Dopamine transporter and vesicular monoamine transporter knockout mice / G.W. Miller [and others] -- Transcription mechanisms for dopamine receptor genes / S.-H. Lee and M. Maral Mouradian -- Detection of DNA/protein interactions in dopamine receptor genes / S.-H. Lee and M. Maral Mouradian -- In situ hybridization on brain tissue / C.-H. Lammers, Y. Hara and M. Maral Mouradian -- Regulation of striatal N-methyl-D-aspartate receptor (NMDAR) function by phosphorylation of its subunits in Parkinsonian rats / J.D. Oh -- Chronic intracerebral delivery of trophic factors via a programmable pump as a treatment for Parkinsonism / R. Grondin [and others] -- Grafting genetically engineered cells into the striatum of nonhuman primates / K.S. Bankiewicz [and others] -- Encapsulated cell implants as a novel treatment for Parkinson's disease / J.L. Tseng and P. Aebischer -- Neural stem cell technology as a novel treatment for Parkinson's disease / R.J.E. Armstrong [and others] |
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880-01/(S Point mutations in the α- synuclein gene / A. Parsian and J.S. Perlmutter -- Autosomal recessive juvenile Parkinsonism (AR-JP): Genetic diagnosis / H. Matsumine, N. Hattori and Y. Mizuno -- Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy as α-synucleinopathies / M. Goedert [and others] -- Α-synuclein/amyloid interactions / P. Henning Jensen -- Functional defect conferred by the Parkinson's disease-causing α-synuclein (ala30Pro) mutation / P. Henning Jensen -- Molecular biology of dopamine-induced apoptosis / I. Ziv [and others] -- Animal models of induced apoptotic death in the substantia nigra / T.F. Oo and R.E. Burke -- Apoptotic morphology in phenotypically defined dopaminergic neurons of the substantia nigra / T.F. Oo and R.E. Burke -- The role of nitric oxide in Parkinson's disease / S. Przedborski and T.M. Dawson -- Oxidative stress indices in Parkinson's disease / M.B.H. Youdim, N. Drigues and S. Mandel -- Quantification of tyrosine hydroxylase mRNA / H. Ichinose [and others] -- Immunochemical analysis of dopaminetransporters in Parkinson's disease / G.W. Miller and A.I. Levey -- Dopamine transporter and vesicular monoamine transporter knockout mice / G.W. Miller [and others] -- Transcription mechanisms for dopamine receptor genes / S.-H. Lee and M. Maral Mouradian -- Detection of DNA/protein interactions in dopamine receptor genes / S.-H. Lee and M. Maral Mouradian -- In situ hybridization on brain tissue / C.-H. Lammers, Y. Hara and M. Maral Mouradian -- Regulation of striatal N-methyl-D-aspartate receptor (NMDAR) function by phosphorylation of its subunits in Parkinsonian rats / J.D. Oh -- Chronic intracerebral delivery of trophic factors via a programmable pump as a treatment for Parkinsonism / R. Grondin [and others] -- Grafting genetically engineered cells into the striatum of nonhuman primates / K.S. Bankiewicz [and others] -- Encapsulated cell implants as a novel treatment for Parkinson's disease / J.L. Tseng and P. Aebischer -- Neural stem cell technology as a novel treatment for Parkinson's disease / R.J.E. Armstrong [and others] |
| Summary |
The use of molecular technologies to study Parkinson's disease in the laboratory is beginning to have a major impact in clinical medicine. In Parkinson's Disease: Methods and Protocols, internationally recognized biomedical investigators describe in detail the major techniques employed in molecular and cellular studies of Parkinson's disease and basal ganglia function, adding along the way considerable background information about the rationale and utility of these methods, as well as about fundamental issues in Parkinson's disease. Widely varied methods are covered, including genetic analyses, molecular pathogenetic investigations of dopaminergic neuronal degeneration, biochemical studies of nigrostriatal neural circuitry, and molecular therapies, such as gene therapy and neural stem cells. Comprehensive and timely, Parkinson's Disease: Methods and Protocols offers scientists and clinicians interested in Parkinson's and related neurodegenerative disorders the major cutting-edge methods-in a readily reproducible format-needed to effectively exploit the potential of cell and molecular biology for elucidating disease mechanisms and for speeding the emergence of novel and more effective therapeutics |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Master and use copy. Digital master created according to Benchmark for Faithful Digital Reproductions of Monographs and Serials, Version 1. Digital Library Federation, December 2002. http://purl.oclc.org/DLF/benchrepro0212 MiAaHDL |
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digitized 2010 HathiTrust Digital Library committed to preserve pda MiAaHDL |
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Print version record |
| Subject |
Parkinson's disease -- Laboratory manuals
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Pathology, Molecular -- Laboratory manuals
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Parkinson Disease -- genetics
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Parkinson Disease -- pathology
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Parkinson Disease -- therapy
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HEALTH & FITNESS -- Diseases -- Alzheimer's & Dementia.
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MEDICAL -- Neurology.
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Parkinson's disease
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Pathology, Molecular
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Parkinson-Krankheit
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Molekulare Medizin
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| Genre/Form |
Laboratory manuals
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| Form |
Electronic book
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| Author |
Mouradian, Maral M
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| LC no. |
00047142 |
| ISBN |
9781592591428 |
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1592591426 |
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0896037614 |
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9780896037618 |
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