INTRODUCTION; FOREWORD; PREFACE; CONTRIBUTORS; CONTENTS; Part One Genomics of Oxygen Sensing; Biochemistry and Physiological Importance of Heme Proteins as Oxygen Sensors; A Role for the Mitochondrion and Reactive Oxygen Species in Oxygen Sensing and Adaptation to Hypoxia in Yeast; Regulation of HIF-1 by Oxygen; Oxygen- or Redox-Dependent Regulation; Structure and Regulation of the Mouse Hypoxia-Inducible Factor-1a Gene; Hypoxia-Inducible Factor-1; Brain Microvascular and Metabolic Adaptation to Prolonged Mild Hypoxia; Molecular Adaptation to Hypoxia
Summary
This text describes the changes in intracellular signalling and gene expression that lead to physiological responses to hypoxia in unicellular, invertebrate, and mammalian species
