| Description |
1 online resource |
| Contents |
An introduction to particle toxicology: from coal mining to nanotechnology / Paul J.A. Borm and Ken Donaldson -- Mineralogy and structure of pathogenic particles / Tim Jones and Kelly BeruBe -- Particle dosimetry: deposition and clearance from the respiratory tract and translocation towards extra-pulmonary sites / Wolfgang G. Kreyling [and others] -- Particulate air pollutants and small airway remodeling / Andrew Churg -- Particle-mediated extracellular oxidative stress in the lung / Frank J. Kelly and Ian S. Mudway -- Particles and cellular oxidative and nitrosative stress / Dale W. Porter, Stephen S. Leonard, and Vincent Castranova -- Interaction of particles with membranes / Barbara Rothen-Rutishauser, Samuel Schurch, and Peter Gehr -- Particle-associated metals and oxidative stress in signaling / James M. Samet and Andrew J. Ghio -- Proinflammatory effects of particles on macrophages and epithelial cells / Vicki Stone [and others] -- Cell-signaling pathways elicited by particulates / Jamie E. Levis and Brooke T. Mossman -- Particle-associated organics and proinflammatory signaling / Francelyne Marano, Sonja Boland, and Armelle Baeza-Squiban -- The asbestos model of interstitial pulmonary fibrosis: TNF-a and TGF-b1 as mediators of asbestos-induced lung fibrogenesis / Deborah E. Sullivan and Arnold R. Brody |
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Effects of particles on the immune system / M. Ian Gilmour, Tina Stevens, and Rajiv K. Saxena -- Effects of particles on the cardiovascular system / Nicholas L. Mills [and others] -- Susceptibility to particle effects / Steven R. Kleeberger and Reuben Howden -- Genotoxic effects of particles / Roel P.F. Schins and Tom K. Hei -- Approaches to the toxicological testing of particles / Ken Donaldson [and others] -- Models for testing the pulmonary toxicity of particles: Lund bioassay screening studies in male rats with a new formulation of TIO2 particulates / David B. Warheit, Kenneth L. Reed, and Christie M. Sayes -- Air pollution and human brain pathology: a role for air pollutants in the pathogenesis of Alzheimer's disease / Lilian Calderon-Garciduenas and William Reed -- Biologically based lung dosimetry and exposure-dose-response models for poorly soluble inhaled particles / Lang Tran and Eileen Kuempel -- Nanoparticles in medicine / Paul J.A. Borm and Detlef Muller-Schulte -- The toxicology of inhaled particles: summing up an emerging conceptual framework / Den Donaldson, Lang Tran, and Paul J.A. Borm |
| Summary |
Exposure to particles in industry and mining and from accidental anthropogenic sources constitutes an ongoing threat. Most recently nanoparticles arising from advances in technology are exposing a wider population to pathogenic stimuli. The effects of inhaled particles are no longer confined to the lung as nanoparticles have the potential to translocate to the bloodstream, the brain, and other target sites. The new questions posed by nanoparticles underscore the importance of interdisciplinary research and exchange and highlight the need for new collaborations among disciplines in medicine, to |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Print version record |
| Subject |
Pulmonary toxicology.
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Particles -- Toxicology
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Inflammation.
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Oxidative stress.
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Air Pollutants -- toxicity
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Inflammation
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Mineral Fibers -- toxicity
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Oxidative Stress
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MEDICAL -- Pulmonary & Thoracic Medicine.
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HEALTH & FITNESS -- Diseases -- Respiratory.
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Oxidative stress
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Inflammation
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Particles -- Toxicology
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Pulmonary toxicology
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| Form |
Electronic book
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| Author |
Donaldson, Kenneth (Toxicologist)
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Borm, Paul.
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| ISBN |
9781420003147 |
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1420003143 |
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1280729961 |
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9781280729966 |
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