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Book Cover
E-book
Author Barlow, D. (David), 1954- author.

Title Chemistry of drugs / David Barlow, David Mountford
Published London : Pharmaceutical Press, 2014

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Description 1 online resource (x, 260 pages) : illustrations
Series FASTtrack
FASTtrack
Contents 880-01 Cover; Title Page; Copyright; Contents; Introduction to the FASTtrack series; Preface; About the authors; Chapter 1. Chemical structure and bonding; Cations and anions; Electron orbitals; Electronic configuration; Molecular orbitals; Promotion; Hybridisation; Bonding; Valence shell electron pair repulsion (VSEPR); Nucleophiles and electrophiles; Drawing chemical structures; Resonance/mesomerism; Drawing resonance hybrids; Self-assessment; Chapter 2. Intermolecular interactions; Importance of intermolecular interactions in pharmacy; Coulombic/electrostatic interactions
880-01/(S Examples of nucleophilic additionAddition of amines -- imine and enamine formation; Reductive amination; Addition-elimination; Changes in hybridisation during addition-elimination; Examples of addition-elimination; α-Hydrogen reactivity; Examples of α-hydrogen reactions; Conjugate addition (Michael addition); Examples of conjugate addition; Reaction with amines and thiols; Self-assessment; Chapter 9. Chemistry of aromatic heterocyclic compounds; Aromaticity in heterocyclic compounds; Naming of heteroaromatic compounds; The basicity of nitrogen heterocyclic compounds
Van der Waals interactionsHydrogen bond interactions; Molecular affinity and the free energy of interaction; Self-assessment; Chapter 3. Acids and bases; Definitions of acids and bases; Acid and base strength; Quantifying the strengths of acids and bases: pKa and pKb values; Importance of acids and bases in pharmacy; Common acidic and basic functional groups; pH and pKa; Amphoteric compounds; Simple buffer solutions; Universal buffer solutions; Self-assessment; Chapter 4. Stereochemistry; Stereochemistry and its importance in pharmaceutical science; Stereoisomers
Fischer's convention of stereochemical nomenclatureConformational isomers; Stereoisomers of cyclic molecules; Geometric isomers; Topological isomers; Self-assessment; Chapter 5. Chemical reaction mechanisms; Nucleophiles and electrophiles; Reaction mechanisms; Curly arrows in reaction mechanisms; Radicals in reaction mechanisms; Fish hooks in reaction mechanisms; Chemical reactivity; Self-assessment; Chapter 6. Chemistry of electrophiles and nucleophiles; Addition and substitution reactions; Electrophilic addition; Nucleophilic substitution; Elimination reactions
Competition between substitution and eliminationSelf-assessment; Chapter 7. Chemistry of aromatic compounds; Benzene; Naming of benzene derivatives; Reactivity; Electrophilic substitution; Electrophilic substitution versus electrophilic addition; Examples of electrophilic substitution; Monosubstituted benzene derivatives; Halogen substituents; Disubstituted benzene derivatives; Self-assessment; Chapter 8. Chemistry of carbonyl compounds; Reactivity of the carbonyl group; Nucleophilic addition; Changes in hybridisation during nucleophilic addition; Stereochemistry in nucleophilic addition
Notes Print version record
Subject Pharmaceutical chemistry -- Examinations -- Study guides
Drugs -- Design -- Examinations -- Study guides
Pharmacy -- Examinations -- Study guides
Drugs -- Design.
Chemistry, Pharmaceutical -- education
Drug Design
Education, Pharmacy
MEDICAL -- Pharmacology.
Drugs -- Design
Pharmacy -- Examinations
Genre/Form exercise books.
Problems and exercises
Study guides
Problems and exercises.
Problèmes et exercices.
Form Electronic book
Author Mountford, David, author
LC no. 2014451375
ISBN 9780857111593
0857111590