| Description |
1 online resource (xxiii, 1093 pages) : illustrations |
| Contents |
Introduction. Pharmacogenomics and stratified medicine -- Basic genetics. Basic genetics: cell, mitosis, meiosis, and Mendelian laws -- Human genome, genomic variation and gene regulation -- Epigenetics -- Experimental and discovery platforms. Animal models in pharmacogenomics -- Human lymphoblastoid cell lines in pharmacogenomics -- Liver expression quantitative trait loci (eQTL) and related approaches to interpret and inform pharmacogenomic studies -- Next gen sequencing -- Proteomics -- Metabolomics -- Stem cells -- Statistics, bioinformatics and databases. Fundamentals of complex trait genetics and association studies -- Bioinformatics -- concepts, methods and data -- PharmGKB: the pharmacogenomics knowledgebase -- Clinical trials. Fundamental pharmacogenomics -- CYP450 and ethnicity -- Pharmacokinetic pharmacogenetics -- Pharmacodynamic pharmacogenetics -- MicroRNA: regulation of P450 and pharmacogenetics -- Applications in therapeutics. Adverse drug reactions -- HLA and the pharmacogenomics of drug hypersensitivity -- Drug induced liver injury -- Haemostasis and anticoagulants -- Pharmacogenomics of warfarin -- Pharmacogenomics of clopidogrel -- Pharmacogenetics of antidepressant drugs -- Personalized medicine of Alzheimer's disease -- Asthma -- Rheumatoid arthritis -- Pharmacogenomics of oral antidiabetic drugs -- Genomics and pharmacogenomics of lipid lowering therapies -- Hypertension pharmacogenomics -- QTc and sudden cardiac death -- Stratified medicine for pancreatic cancer -- Pharmacogenomics in anaesthesia -- Tuberculosis -- Hepatitis C virus -- Pharmacogenomics of antifungal agents -- Advances in understanding and treatment of human African trypanosomiasis: divergent diseases caused by distinct parasites -- Implementation and Regulatory. Implementing clinical pharmacogenetics: point-of-care and pre-emptive testing -- Ethical considerations for pharmacogenomic testing in paediatrics -- PGx/biomarker utilization for regulatory decision making -- Global perspective. Population diversity and pharmacogenomics in Africa -- Pharmacogenomics in China -- Pharmacogenomics in Brazil -- Pharmacogenomics in India |
| Summary |
"Handbook of Pharmacogenomics and Stratified Medicine is a comprehensive resource to understand this rapidly advancing field aiming to deliver the right drug at the right dose to the right patient at the right time. It is designed to provide a detailed, but accessible review of the entire field from basic principles to applications in various diseases. The chapters are written by international experts to allow readers from a wide variety of backgrounds, clinical and non-clinical (basic geneticists, pharmacologists, clinicians, trialists, industry personnel, ethicists) to understand the principles underpinning the progress in this area, the successes, failures and the challenges ahead. To be accessible to the widest range of readers, the clinical application section introduces the disease process, existing therapies, followed by pharmacogenomics and stratified medicine details"--Publisher's description |
| Bibliography |
Includes bibliographical references and index |
| Notes |
English |
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Online resource; title from resource home page (ebrary, viewed November 16, 2015) |
| Subject |
Pharmacogenomics -- Handbooks, manuals, etc
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Pharmacogenetics.
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Precision medicine
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Pharmacogenetics
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Precision Medicine
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MEDICAL -- Pharmacology.
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Precision medicine
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Pharmacogenetics
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Pharmacogenomics
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| Genre/Form |
manuals (instructional materials)
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handbooks.
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Handbooks and manuals
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Handbooks and manuals.
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Guides et manuels.
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| Form |
Electronic book
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| Author |
Padmanabhan, Sandosh, editor
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| ISBN |
9780123868831 |
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0123868831 |
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