| Description |
1 online resource |
| Contents |
Cover; Title Page; Copyright; Dedication; Preface; Chapter 1: Thermodynamics; 1.1 Introduction; 1.2 The Fundamental Postulates or Laws of Thermodynamics; 1.3 Other Useful Quantities and Concepts; 1.4 Thermodynamics of the Ideal Gas; 1.5 Thermodynamics of Solutions; 1.6 Phase Equilibria; 1.7 Chemical Equilibria; 1.8 Temperature Dependence of Chemical Equilibria: The Van't Hoff Equation; 1.9 Microcalorimetry; Chapter 2: Four Basic Quantum Mechanical Models of Nuclear and Electronic Motion: A Synopsis; 2.1 Introduction; 2.2 Fundamental Hypotheses of Quantum Theory |
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2.3 Three Simple Models of Nuclear Motion2.4 Hydrogen Atomic Orbitals: A Simple Model of Electronic Motion in Atoms; 2.5 Many Electron Atoms; Suggested Reading; Chapter 3: Molecular Structure and Interactions; 3.1 Introduction; 3.2 Chemical Bonding: Electronic Structure of Molecules; 3.3 Empirical Classical Energy Expressions; 3.4 Noncovalent Forces Between Atoms and Molecules; 3.5 Molecular Mechanics; Suggested Reading; Chapter 4: Water and the Hydrophobic Effect; 4.1 Introduction; 4.2 Structure of Liquid Water; 4.3 THE HYDROPHOBIC EFFECT; Suggested Reading |
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Chapter 5: The Molecular Partition Function5.1 Introduction; 5.2 The Maxwell-Boltzmann Distribution; 5.3 The Molecular Partition Function and Thermodynamic Functions; 5.4 Application to Macromolecules; Suggested Reading; Chapter 6: System Ensembles and Partition Functions; 6.1 Introduction; 6.2 Closed Systems: The Canonical Ensemble; 6.3 The Canonical Partition Function of Systems with Continuous Energy Distributions: The Phase-Space Integral; 6.4 Application: Relation Between Binding and Molecular Interaction Energy; 6.5 Application: Binding of Ligand to a Macromolecule |
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6.6 Open Systems: The Grand Canonical Ensemble or Grand Ensemble6.7 Fluctuations; 6.8 Application: Light Scattering as a Measure of Fluctuations of Concentration; Suggested Reading; Chapter 7: Sampling Molecular Systems with Simulations; 7.1 Introduction; 7.2 Background; 7.3 Molecular Dynamics; 7.4 Metropolis Monte Carlo; 7.5 Simulation of A Condensed System; 7.6 Connecting Microscopic and Macroscopic System Properties; 7.7 An Example: Dynamics of Ace-Ala-Nme in Solution; 7.8 Forced Transitions; 7.9 Potential of Mean Force for Changes of Chemistry: "Computer Alchemy." |
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7.10 The Potential of Mean Force and the Association Equilibrium Constant of MethaneSuggested Reading; Chapter 8: Binding Equilibria; 8.1 Introduction; 8.2 Single-Site Model; 8.3 Measuring Ligand Activity and Saturation; 8.4 Multiple Sites for a Single Ligand; 8.5 A Few Practical Recommendations; Suggested Reading; Chapter 9: Thermodynamics of Molecular Interactions; 9.1 Introduction; 9.2 Relation Between Binding and Chemical Potential: Unified Formulation of Binding and "Exclusion"; 9.3 Free Energy of Binding; 9.4 Mutual Response; 9.5 Volume Exclusion |
| Summary |
Equilibria and Kinetics of Biological Macromolecules provides readers with an understanding of the biophysics of macromolecules. Presentedwitha pedagogical approach, beginning with introductory concepts, the bookaddresses thermodynamics, statistical mechanics, ligand binding of proteins, and conformational stability, before focusing on focuses on kinetics and equilibria via discussion of discussion of theory, protein folding, and stochastic models. Placing a strong emphasis on molecular interactions, this reference also contains extensive appendices offer refreshers on probability, deriving grand partial functions, computational methods, helix-coil transition theory, laplace transformation, Poisson equation, defining molecular boundaries, and various equations, among other useful facts |
| Notes |
Title from resource description page (Recorded Books, viewed November 21, 2013) |
| Subject |
Science.
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Biocompatible Materials -- pharmacokinetics
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Biophysical Phenomena
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Macromolecular Substances -- pharmacokinetics
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Molecular Conformation
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Science
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sciences (philosophy)
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science (modern discipline)
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SCIENCE -- Life Sciences -- Biochemistry.
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Science
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| Form |
Electronic book
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| Author |
Hermans, Jan
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| ISBN |
9781118733776 |
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1118733770 |
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