Title Applications of minimally invasive nanomedicine-based therapies in 3D in vitro cancer platforms / Layla Mohammad-Hadi and Marym Mohammad-Hadi

Published Cham, Switzerland : Springer, [2020]

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Description 1 online resource (xv, 93 pages) : illustrations (some color) Series Synthesis lectures on materials and optics, 2691-1949 ; #6 Synthesis digital library of engineering and computer science. Synthesis lectures on materials and optics ; #6 Contents 1. Introduction -- 1.1. Introduction -- 1.2. References 2. Photodynamic therapy and photochemical internalization -- 2.1. Introduction -- 2.2. Photodynamic therapy -- 2.3. Light sources used in PDT -- 2.4. Clinical trials of PDT in cancer patients -- 2.5. Clinical trials in non-cancerous diseases -- 2.6. Photochemical internalization -- 2.7. Different mechanisms of endocytosis -- 2.8. Clinical trials of PCI -- 2.9. Potential advantages of PCI over PDT -- 2.10. References 3. Photosensitizers and therapeutic agents used in PDT and PCI -- 3.1. Introduction -- 3.2. Photosensitizers used in PDT. -- 3.3. Photosensitizers used in PCI -- 3.4. Chemotherapeutic drugs used in PCI -- 3.5. PCI for the delivery of genetic material into cells -- 3.6. Viral gene delivery through PCI -- 3.7. PCI in cancer vaccination -- 3.8. References 4. The use of nanoparticles in PDT and PCI -- 4.1. Introduction -- 4.2. Roles of different nanoparticles in PDT and PCI -- 4.3. Biodegradable nanoparticles -- 4.4. Non-biodegradable nanoparticles -- 4.5. References 5. 3D in vitro cancer models. -- 5.1. Introduction -- 5.2. Three-dimensional (3D) in vitro cell culture models -- 5.3. References 6. The applications of PDT and PCI in 3D in vitro cancer models -- 6.1. Introduction -- 6.2. PDT in 3D cancer models -- 6.3. Application of PDT involving nanoparticles in 3D cancer models -- 6.4. PCI in 3D cancer models -- 6.5. References Summary Minimally invasive techniques such as Photodynamic Therapy (PDT) and Photochemical Internalisation (PCI) have for years been under investigation for the treatment of solid cancers. A significant number of the recent research studies have applied PDT and PCI to biological three-dimensional (3D) cancer platforms with many of the studies also involving the use of nanoparticles in order to enhance the efficacy of these light-based therapies. Interest in the employment of 3D cancer platforms has increased considerably due to the ability of the platforms to mimic in vivo models better than the conventional two-dimensional (2D) cultures. Some of the advantages of the 3D cancer systems over their 2D counterparts include improved interaction between cancer cells and the surrounding extracellular matrix (ECM) as well as restricted drug penetration which would allow optimization of treatments prior to undertaking of in vivo studies. The different chapters of this book will discuss photosensitizers and nanoparticles used in PDT and PCI in addition to the applications of these treatments in various 3D cancer models Analysis light therapy non-invasive medicine 3D models nanomedicine photodynamic therapy photochemical internalization Bibliography Includes bibliographical references Notes Title from PDF title page (viewed on November 10, 2020) Subject Cancer -- Treatment -- Simulation methods Cancer -- Phototherapy -- Simulation methods Cancer -- Photochemotherapy -- Simulation methods Nanomedicine. Phototherapy. Photochemotherapy. Neoplasms -- therapy Neoplasms -- drug therapy Phototherapy Photochemotherapy Nanostructures -- therapeutic use Nanomedicine Phototherapy Photochemotherapy Nanomedicine Form Electronic book Author Mohammad-Hadi, Marym, author ISBN 9781681739700 1681739704 9783031023880 3031023889

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