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Title Water extraction of bioactive compounds : from plants to drug development / edited by Herminia Dominguez González, María Jesús González Muñoz
Published Amsterdam, Netherlands ; Cambridge, MA : Elsevier, [2017]

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Description 1 online resource
Contents Front Cover; Water Extraction of Bioactive Compounds; Water Extraction of Bioactive Compounds; Copyright; Contents; List of Contributors; Foreword; Preface; 1 -- Introduction; 1. BOTANICAL THERAPY; 1.1 Plant Constituents and Biological Actions; 1.2 Strategies in the Discovery of Novel Botanical Bioactives; 1.3 Challenges and Opportunities for Natural Products; 2. SUSTAINABLE SOURCES AND UTILIZATION OF BIOACTIVES; 3. EXTRACTION; 3.1 Mechanisms and Kinetics; 3.2 Mathematical Modeling; 3.2.1 Fick's Law Model; 3.2.2 Empirical Models; 3.3 Operational Variables
3.3.1 Thermal and Mechanical Treatments3.3.2 Particle Size; 3.3.3 Temperature; 3.3.4 Solvent; 3.3.5 Solvent-to-Solid Ratio; 3.3.6 Searching for Green Solvents; 4. ADVANCED EXTRACTION PROCESSES; 4.1 Nonconventional Green Extraction Techniques; 4.2 Intensified Strategies; 4.3 Intensified Assisted Solvent Extraction Techniques; 4.3.1 Subcritical Water Extraction; 4.3.2 Microwave-Assisted Extraction; 4.3.3 Ultrasonic-Assisted Extraction; 4.3.4 Enzyme-Assisted Extraction; 4.3.5 Electrically Assisted Extraction; 4.3.5.1 High-Voltage Electrical Discharge; 4.3.5.2 Pulsed Electric Field
4.3.6 Negative Pressure Cavitation Extraction4.3.6.1 Future Trends; REFERENCES; 2 -- Therapeutic Compounds From Plants Using Subcritical Water Technology; 1. INTRODUCTION; 2. PROPERTIES OF WATER; 2.1 The Hydrogen Bond; 2.2 Density and Viscosity; 2.3 The Dielectric Constant; 2.4 Ion Product; 3. INSTRUMENTS AND BASIC EXPERIMENTAL SETUP FOR SWE; 4. APPLICATION OF SWE IN PHARMACEUTICAL INDUSTRY; 4.1 Extraction of Essential Oils; 4.2 Preparation of Plant Extracts; 4.3 Extraction of Phenolic Compounds; 4.4 Preparation of Enriched Extract; 4.5 Extraction of Polysaccharides
4.6 Extraction of Alkaloids4.7 Extraction of Other Natural Products; REFERENCES; FURTHER READING; 3 -- Hydrolysis of Biopolymers in Near-Critical and Subcritical Water; 1. INTRODUCTION; 2. PROPERTIES OF WATER IN NEAR-CRITICAL AND SUBCRITICAL WATER; 2.1 Ion Product; 2.2 Dielectric Constant; 2.3 Water Density; 2.4 Hydrogen Bonding; 3. PLANT BIOPOLYMERS: CELLULOSE, HEMICELLULOSE, AND LIGNIN; 3.1 Cellulose; 3.2 Hemicellulose; 3.3 Lignin; 4. DEGRADATION PATHWAYS OF PLANT BIOPOLYMERS; 4.1 Cellulose; 4.2 Hemicellulose; 4.3 Lignin; 5. SUBCRITICAL WATER EXTRACTION FOR MACROALGAE; 5.1 Carrageenan
5.2 Phenolic Compounds6. CONCLUSION AND FUTURE DIRECTION; REFERENCES; 4 -- Subcritical Water Extraction and Neoformation of Antioxidants; 1. INTRODUCTION; 2. FUNDAMENTALS OF SUBCRITICAL WATER EXTRACTION; 2.1 Temperature; 2.2 Pressure; 2.3 Flow Rate and Extraction Time; 2.4 Other Parameters; 3. INSTRUMENTATION FOR SUBCRITICAL WATER EXTRACTION; 4. EXTRACTION OF ANTIOXIDANTS BY SUBCRITICAL WATER EXTRACTION; 5. NEOFORMATION OF ANTIOXIDANTS BY SUBCRITICAL WATER EXTRACTION; 5.1 Formation of Antioxidants Due To Hydrolysis; 5.2 Formation of Antioxidants Due To Degradation Mechanisms
Summary Water Extraction of Bioactive Compounds: From Plants to Drug Development draws together the expert knowledge of researchers from around the world to outline the essential knowledge and techniques required to successfully extract bioactive compounds for further study. The book is a practical tool for medicinal chemists, biochemists, pharmaceutical scientists and academics working in the discovery and development of drugs from natural sources. The discovery and extraction of bioactive plant compounds from natural sources is of growing interest to drug developers, adding greater fuel to a simultaneous search for efficient, green technologies to support this. Particularly promising are aqueous based methods, as water is a cheap, safe and abundant solvent. Water Extraction of Bioactive Compounds: From Plants to Drug Development is a detailed guide to the fundamental concepts and considerations needed to successfully undertake such processes, supported by application examples and highlighting the most influential variables. Beginning with an introduction to plants as sources of drugs, the book highlights the need for a move towards both more rational and greener techniques in the field, and presents multiple innovative water-based strategies for the discovery and extraction of bioactive constituents of botanicals. A broad range of available techniques are reviewed, including conventional and pressurized hot water extraction techniques, intensified processes such as microwave-assisted, ultrasound-assisted processes, and enzyme assisted extraction, and processes using combined techniques
Notes Includes index
Online resource; title from digital title page (viewed on August 21, 2019)
Subject Plant bioactive compounds -- Separation
Pharmaceutical technology.
Technology, Pharmaceutical
MEDICAL -- Pharmacology.
Pharmaceutical technology.
Genre/Form Electronic books
Form Electronic book
Author Domínguez, Herminia, editor
González Muñoz, María Jesús, editor
ISBN 9780128096154
0128096152