| Description |
1 online resource |
| Contents |
Plant Chemical Biology -- Copyright -- Contents -- Preface -- Contributors -- Part One Introduction -- 1.1 From Herbal Remedies to Cutting-Edge Science: A Historical Perspective of Plant Chemical Biology -- 1.1.1 Herbal Remedies and Pharmacology in the Ancient World -- 1.1.2 Alchemy, Chemistry, and the Isolation of the Bioactive Metabolites -- 1.1.3 The Discovery of Phytohormones and the Foundation of Modern Plant Chemical Biology -- 1.1.4 The Dawn of Plant Synthetic Chemistry -- 1.1.5 Serendipity Versus Rational Design of Chemical Libraries -- 1.1.6 The Development of Combinatorial Chemistry -- 1.1.7 Plant Chemical Biology in the -Omics Era -- 1.1.8 Introduction of Bioinformatics and Cheminformatics -- 1.1.9 Unique Challenges in the Field of Chemical Genomic Research -- 1.1.10 Concluding Remarks -- Acknowledgments -- References -- Part Two Sources of Small Molecules -- 2.1 Compound Collections -- 2.1.1 Introduction -- 2.1.2 Commercial Sources -- 2.1.3 Companies Providing Nonproprietary, Nonparallel Synthesized Libraries Sourced Externally to the Company -- 2.1.4 Companies Providing In-House Designed, Parallel Synthesized Libraries -- 2.1.5 Results of Database Analysis -- 2.1.6 Compound Selection and Database Filtering -- 2.1.7 Substructure Similarity/Dissimilarity -- 2.1.8 Cluster Analysis -- 2.1.9 Pharmacophore Analysis -- 2.1.10 Compound Acquisition Format and Storage -- Acknowledgments -- References -- 2.2 Combinatorial Chemistry Library Design -- 2.2.1 Introduction -- 2.2.2 Bioavailability -- 2.2.3 Chemical Space -- 2.2.4 Privileged Structures -- 2.2.5 Fragment-Based Design -- 2.2.6 Ligand-Based Design -- 2.2.7 Structure-Based Design -- 2.2.8 Conclusion and Summary -- References -- 2.3 Natural Product-Based Libraries -- 2.3.1 Introduction -- 2.3.2 Plant-Based Collections -- 2.3.3 Microbial-Derived Samples -- 2.3.4 Samples of Marine Origin |
|
2.3.5 Future Perspectives -- 2.3.6 Concluding Remarks -- References -- Part Three Identification of New Chemical Tools by High-Throughput Screening -- 3.1 Assay Design for High-Throughput Screening -- 3.1.1 Introduction -- 3.1.2 Approaching Assay Development -- 3.1.3 Assay Development -- 3.1.4 Assay Types and Considerations -- 3.1.5 Automation Adaptation and Validation -- 3.1.6 Closing -- Acknowledgment -- References -- Part Four Use of Chemical Biology to study Plant Physiology -- 4.1 Use of Chemical Biology to Understand Auxin Metabolism, Signaling, and Polar Transport -- 4.1.1 Introduction -- 4.1.2 Naturally Occurring Auxins -- 4.1.3 Auxin Biosynthesis -- 4.1.4 Auxin Conjugation and Release by Hydrolysis -- 4.1.5 Synthetic Auxins -- 4.1.6 Polar Auxin Transport -- 4.1.7 Current Models of Auxin Signaling -- 4.1.8 Application of Auxin-Related Molecules in Chemical Genetic Approach -- 4.1.9 Chemical Probes on Auxin Signaling from Chemical Library and Natural Sources -- 4.1.10 Rational Design of Auxin Antagonist on the Basis of TIR1 Structure -- 4.1.11 Chemical Probes on Auxin Transport from Chemical Library and Natural Sources -- 4.1.12 Concluding Remarks -- References -- 4.2 Brassinosteroids Signaling and Biosynthesis -- 4.2.1 Brassinosteroid Research Moves into the Era of Chemical Biology -- 4.2.2 Brassinosteroid Regulators -- 4.2.3 Brassinosteroid Receptors -- 4.2.4 Chemical Biology Research by Genetic Techniques Utilizing Brassinosteroid Biosynthesis Inhibitors: Chemical Genetics -- 4.2.5 Chemical Biology Research by Plant Physiological Techniques Utilizing Brassinosteroid Biosynthesis Inhibitors -- 4.2.6 Chemical Biology Research by Utilization of Brassinosteroid Biosynthesis Inhibitor in Cell Imaging and Biochemical Studies |
|
4.2.7 Chemical Genetics with a Focus on the Regulatory Activity of Brassinosteroid Biosynthesis Inhibitors on the Chloroplast Function -- 4.2.8 Outlook for the Future -- References -- 4.3 Chemical Genetic Approaches on ABA Signal Transduction -- 4.3.1 Abscisic Acid Signal Transduction: Lessons from Exogenous ABA Treatment -- 4.3.2 Abscisic Acid Signal Transduction: Lessons from ABA Derivatives Treatment -- 4.3.3 Abscisic Acid Signal Transduction: New Insights from Chemical Genetics -- 4.3.4 Pyrabactin and Its Cellular Target PYR1 : Discovery of ABA Receptors, PYR / PYL /RCARS -- 4.3.5 ABA Antagonist DFPM : Mechanisms for Crosstalks Between Abiotic and Biotic Signaling Pathways -- 4.3.6 Summary -- References -- 4.4 Jasmonic Acid -- 4.4.1 Introduction: Jasmonic Acid and Related Bioactive Molecules -- 4.4.2 Jasmonate Biosynthesis Pathway -- 4.4.3 Metabolic Conversion and Structure-Activity Relationship of Jasmonates -- 4.4.4 (+)-7- iso -Jasmonoyl- L -Isoleucine Is the Natural Bioactive Jasmonate -- 4.4.5 Dissecting the JA Signaling Pathway -- 4.4.6 Receptor of the Native Bioactive Jasmonate, JA -ILE -- 4.4.7 Searching for Additional JA Signaling Pathways and Components -- 4.4.8 Conclusions -- Ackowledgment -- References -- 4.5 Chemical Genetics as a Tool to Study Ethylene Biology in Plants -- 4.5.1 Introduction -- 4.5.2 Small Molecules in Ethylene Biosynthesis and Signaling -- 4.5.3 Possible Screens and Recent Findings in Chemical Genetics of Ethylene -- 4.5.4 Chemical Genetics in Ethylene-Hormone Interaction Studies -- 4.5.5 Target Identification -- 4.5.6 Future Perspectives -- References -- Part Five Use of Chemical Biology to Study Plant Cellular Processes -- 5.1 The Use of Small Molecules to Dissect Cell Wall Biosynthesis and Manipulate the Cortical Cytoskeleton -- 5.1.1 Introduction |
|
5.1.2 The Power of Molecular Genetics in the Study of Cell Walls -- 5.1.3 Why Use Chemical Genetics to Study Plant Cell Walls? -- 5.1.4 The Use of Chemical Genetics in Cell Wall Research -- Acknowledgments -- References -- 5.2 The use of Chemical Biology to Study Plant Cellular Processes: Subcellular Trafficking -- 5.2.1 The Plant Endomembrane System, a Complex Network Essential for Diverse Developmental Functions -- 5.2.2 Chemical Genomics Strategies to Study the Plant Trafficking Network -- 5.2.3 The Identification of Novel Compounds Targeting the Plant Trafficking Network -- 5.2.4 Chemical Genomics Can Target Evolutionarily Conserved Pathways in Eukaryotes -- 5.2.5 Broadly Used Bioactive Natural Compounds to Investigate Vesicular Trafficking in Plants -- 5.2.6 Advantages of a Chemical Genomics Strategy to Dissect the Plant Endomembrane System -- 5.2.7 Concluding Remarks -- Acknowledgments -- References -- Part Six Target Identification -- 6.1 Target Identification of Biologically Active Small Molecules -- 6.1.1 Introduction -- 6.1.2 Affinity-Based Approaches to Identify Protein Targets -- 6.1.3 Variation on the Affinity Approach to Target Identification -- 6.1.4 Label-Free Approaches -- 6.1.5 Genetic Approaches for Identifying Targets or Pathways of Novel Compounds -- References -- Part Seven Translation of Plant Chemical Biology from the Lab to the Field -- 7.1 Prospects and Challenges for Translating Emerging Insights in Plant Chemical Biology into New Agrochemicals -- 7.1.1 Introduction -- 7.1.2 Plant Chemical Biology Toward Herbicide Discovery -- 7.1.3 Plant Chemical Biology Toward Agrochemicals for Plant Protection -- 7.1.4 Plant Chemical Biology Toward Agrochemicals for Plant Improvement and Yield -- 7.1.5 Chemical Probes Versus Agrochemical Lead -- 7.1.6 Conclusion -- References -- 7.2 In Vitro Propagation |
|
7.2.1 Plant Tissue Culture as a Historical Basis for the Discovery of Plant Growth Regulators -- 7.2.2 Cytokinins Used in Tissue Culture -- 7.2.3 Auxins Used in Tissue Culture -- 7.2.4 Hormones in Tissue Culture Applications -- 7.2.5 Concluding Remarks -- References -- Index -- Supplementary Images |
| Summary |
The application of plant chemical biology is currently limited to specialized subfields of plant research. By examining how chemical biology can be applied to study plant biology, Plant Chemical Biology illustrates how chemical biology is a means to identify small molecules that can be used to identify the targets of currently used herbicides, as well as to develop new herbicides or plant growth regulators. The author introduces researchers and graduate students to the chemical biology toolbox required to perform successful chemical biology studies. The text also examines several chemical biol |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Print version record |
| Subject |
Botanical chemistry.
|
|
Plants -- Chemical warfare
|
|
Biochemical Phenomena
|
|
Plant Physiological Phenomena
|
|
Plant physiology.
|
|
Plants -- chemistry
|
|
Biochemical Phenomena
|
|
Plant Physiological Phenomena
|
|
Plant physiology
|
|
Botanical chemistry
|
| Form |
Electronic book
|
| ISBN |
1306118379 |
|
9781306118378 |
|
9780470946695 |
|
0470946695 |
|
9781118743171 |
|
1118743172 |
|
9781118742747 |
|
1118742745 |
|
