Limit search to available items
Book Cover

Title Polyamine drug discovery / edited by Patrick M. Woster, Robert A. Casero Jr
Published [Cambridge, U.K.] : Royal Society of Chemistry, [2011], ©2012


Description 1 online resource (xii, 289 pages) : illustrations
Series RSC drug discovery series ; no. 17
RSC drug discovery series ; 17.
Contents Polyamine Drug DiscoveryOFC_Publicity; i-iv; v-vi; vii-xii; 1-27.pdf; 28-49; 50-77; 78-103; 104-134; 135-161; 162-190; 191-204; 205-237; 238-256; 257-276; 277-290
Summary Polyamines are ubiquitous molecules that are involved in a number of important cellular processes. Aberrations in their function or metabolism play a role in diseases such as cancer and parasitic infection. A number of validated drug targets have been identified, including enzymes in the polyamine biosynthetic and catabolic pathways and the S-adenosylmethionine synthetic and salvage pathways. Polyamine Drug Discovery is the first comprehensive volume to cover all aspects of the design and development of potential therapeutics targeting polyamine metabolism. The book details research progress from 1975 to the present date and discusses the design and use of polyamine metabolism inhibitors as therapeutic agents. Various polyamine-containing drugs are described that can be used in chemotherapy, and as treatments for infections including trypanosomiasis, leishmaniasis and malaria. Finally, the roles of polyamine analogues in chemoprevention, polyamine-containing vectors for gene delivery, and the design of polyamine-based epigenetic modulators are detailed. Each chapter addresses a different aspect of polyamine drug discovery and all are written by medicinal and biological chemists with particular expertise in developing agents that modulate polyamine metabolism or function. The book will increase the visibility of polyamine drug discovery among pharmaceutical researchers and provide a valuable reference for everyone working in the field
Bibliography Includes bibliographical references and index
Notes Print version record
Subject Drug development.
Polyamines -- Therapeutic use
Pharmaceutical chemistry.
Organic compounds.
Life sciences.
Physical sciences.
Investigative Techniques
Chemistry, Pharmaceutical
Organic Chemicals
Analytical, Diagnostic and Therapeutic Techniques and Equipment
Biological Science Disciplines
Natural Science Disciplines
Chemicals and Drugs
Disciplines and Occupations
Drug Discovery
organic compounds.
biological sciences.
physical sciences.
MEDICAL -- Drug Guides.
MEDICAL -- Nursing -- Pharmacology.
MEDICAL -- Pharmacology.
MEDICAL -- Pharmacy.
Physical sciences
Pharmaceutical chemistry
Organic compounds
Life sciences
Drug development
Form Electronic book
Author Woster, Patrick M.
Casero, Robert Anthony.
Royal Society of Chemistry (Great Britain)
ISBN 9781849733090