| Description |
1 online resource (xv, 102 pages) |
| Series |
Springer theses |
|
Springer theses.
|
| Contents |
Copper-Catalyzed Multi-Component Reactions; Supervisor's Foreword; Acknowledgments; Contents; 1 Introduction; References; Part I Synthesis of Indole Derivatives; 2 Construction of 2-(Aminomethyl)indoles Through Copper-Catalyzed Domino Three-Component Coupling and Cyclization; 3 Facile Synthesis of 1,2,3,4-Tetrahydro- beta -Carbolines by One-Pot Domino Three-Component Indole Formation and Nucleophilic Cyclization; 4 Concise Synthesis of Indole-Fused 1,4-Diazepines through Copper(I)-Catalyzed Domino Three-Component Coupling-Cyclization-N-Arylation under Microwave Irradiation |
|
Part II Synthesis of Isoquinoline Derivatives5 Facile Synthesis of 3-(Aminomethyl)isoquinoline by Copper-Catalyzed Domino Four-Component Coupling and Cyclization; 6 Rapid Access to 3-(Aminomethyl)isoquinoline-Fused Polycyclic Compounds by Copper-Catalyzed Four Component Coupling, Cascade Cyclization, and Oxidation; 7 Conclusions |
| Summary |
A copper-catalyzed direct synthesis of 2-(aminomethyl)indoles by catalytic domino reaction including multi-component coupling was developed, and is the first example of a three-component indole formation without producing salts as a byproduct. Based on this reaction, a copper-catalyzed synthesis of 3-(aminomethyl)isoquinoline was accomplished which represents an unprecedented isoquinoline synthesis through a four-component coupling reaction. Following these results, extensive application studies using one-pot palladium-, acid-, or base-promoted cyclization revealed that indole- or isoquinoline |
| Notes |
Ph. D. Kyoto University 2010 |
| Bibliography |
Includes bibliographical references |
| Notes |
Print version record |
| Subject |
Polycyclic compounds -- Synthesis
|
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SCIENCE -- Chemistry -- Organic.
|
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Chimie.
|
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Science des matériaux.
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Polycyclic compounds -- Synthesis
|
| Genre/Form |
dissertations.
|
|
Academic theses
|
|
Academic theses.
|
|
Thèses et écrits académiques.
|
| Form |
Electronic book
|
| LC no. |
2010938324 |
| ISBN |
9783642154737 |
|
3642154735 |
|
3642154727 |
|
9783642154720 |
|
