Description |
1 online resource (xv, 102 pages) |
Series |
Springer theses |
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Springer theses.
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Contents |
Copper-Catalyzed Multi-Component Reactions; Supervisor's Foreword; Acknowledgments; Contents; 1 Introduction; References; Part I Synthesis of Indole Derivatives; 2 Construction of 2-(Aminomethyl)indoles Through Copper-Catalyzed Domino Three-Component Coupling and Cyclization; 3 Facile Synthesis of 1,2,3,4-Tetrahydro- beta -Carbolines by One-Pot Domino Three-Component Indole Formation and Nucleophilic Cyclization; 4 Concise Synthesis of Indole-Fused 1,4-Diazepines through Copper(I)-Catalyzed Domino Three-Component Coupling-Cyclization-N-Arylation under Microwave Irradiation |
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Part II Synthesis of Isoquinoline Derivatives5 Facile Synthesis of 3-(Aminomethyl)isoquinoline by Copper-Catalyzed Domino Four-Component Coupling and Cyclization; 6 Rapid Access to 3-(Aminomethyl)isoquinoline-Fused Polycyclic Compounds by Copper-Catalyzed Four Component Coupling, Cascade Cyclization, and Oxidation; 7 Conclusions |
Summary |
A copper-catalyzed direct synthesis of 2-(aminomethyl)indoles by catalytic domino reaction including multi-component coupling was developed, and is the first example of a three-component indole formation without producing salts as a byproduct. Based on this reaction, a copper-catalyzed synthesis of 3-(aminomethyl)isoquinoline was accomplished which represents an unprecedented isoquinoline synthesis through a four-component coupling reaction. Following these results, extensive application studies using one-pot palladium-, acid-, or base-promoted cyclization revealed that indole- or isoquinoline |
Notes |
Ph. D. Kyoto University 2010 |
Bibliography |
Includes bibliographical references |
Notes |
Print version record |
Subject |
Polycyclic compounds -- Synthesis
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SCIENCE -- Chemistry -- Organic.
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Chimie.
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Science des matériaux.
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Polycyclic compounds -- Synthesis
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Genre/Form |
dissertations.
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Academic theses
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Academic theses.
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Thèses et écrits académiques.
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Form |
Electronic book
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LC no. |
2010938324 |
ISBN |
9783642154737 |
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3642154735 |
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3642154727 |
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9783642154720 |
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