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Title Cox-2 : a new target for cancer prevention and treatment / volume editors, Andrew J. Dannenberg, Raymond N. DuBois
Published Basel ; New York : Karger, ©2003


Description 1 online resource (viii, 291 pages) : illustrations (some color)
Series Progress in experimental tumor research ; v. 37
Progress in experimental tumor research ; v. 37.
Summary Numerous investigators have found increased levels of cyclooxygenase-2 (COX-2) in both pre-malignant and malignant tissues. Moreover, animals engineered to be COX-2 deficient or treated with a selective COX-2 inhibitor showed reduced tumor formation and growth. The present book reviews these findings suggesting that COX-2 is a valid molecular target for the prevention and treatment of cancer. The first chapters are devoted to the epidemiology of nonsteroidal anti-inflammatory drugs (NSAIDs) and cancer, the pharmacology of COX-2 inhibitors and the regulation of COX-2 expression in human cancers. Besides, the book contains a series of chapters examining the link between COX-2 and cancer in specific organs (e.g. skin, breast, cervix, digestive tract, lung, etc.). Furthermore, several clinical trials assessing the potential of COX-2 inhibitors for preventing and treating cancer are described. The final chapter provides an up-to-date consideration of COX-independent targets of NSAIDs and related compounds in cancer prevention and treatment. This state-of-the-art publication is recommended reading not only for medical and radiation oncologists, but also for pharmacologists, gastroenterologists and other subspecialists
Analysis Andre fag (naturvidenskab og teknik) Andre fag
Bibliography Includes bibliographical references and indexes
Notes Master and use copy. Digital master created according to Benchmark for Faithful Digital Reproductions of Monographs and Serials, Version 1. Digital Library Federation, December 2002. MiAaHDL
Print version record
digitized 2010 HathiTrust Digital Library committed to preserve pda MiAaHDL
Subject Cyclooxygenase 2 -- Inhibitors -- Therapeutic use
Cancer -- Chemotherapy.
Neoplasms -- drug therapy
Cyclooxygenase Inhibitors -- therapeutic use
Cancer -- Chemotherapy
Krebs <Medizin> -- Prävention -- Prostaglandinsynthase -- Inhibitor -- Aufsatzsammlung.
Prostaglandinsynthase -- Inhibitor -- Krebs <Medizin> -- Prävention -- Aufsatzsammlung.
Inhibitor -- Prostaglandinsynthase -- Krebs <Medizin> -- Prävention -- Aufsatzsammlung.
Krebs <Medizin> -- Therapie -- Prostaglandinsynthase -- Inhibitor -- Aufsatzsammlung.
Prostaglandinsynthase -- Inhibitor -- Krebs <Medizin> -- Therapie -- Aufsatzsammlung.
Inhibitor -- Prostaglandinsynthase -- Krebs <Medizin> -- Therapie -- Aufsatzsammlung.
Form Electronic book
Author Bertino, Joseph R
ISBN 9783318009408